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Reviewed, UniProtKB/Swiss-Prot Q57D01 (TPIS1_BRUAB)

Last modified November 3, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Triosephosphate isomerase 1
      Short name=TIM 1
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase 1
Gene names
Name: tpiA1
Synonyms: tpiA, tpiA-1
Ordered Locus Names: BruAb1_1144
OrganismBrucella abortus [Complete proteome] [HAMAP]
Taxonomic identifier235 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

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Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the triosephosphate isomerase family.

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Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: HAMAP

glycolysis

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Triosephosphate isomerase 1 HAMAP MF_00147
PRO_0000090188

Sites

Active site991Electrophile By similarity
Active site1691Proton acceptor By similarity
Binding site121Substrate By similarity
Binding site141Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q57D01-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 5E4A4A575FB4E65D

FASTA25426,485
        10         20         30         40         50         60 
MTPGIRPLVA GNWKMNGKGE SLTELRAIAA GLSSDLGRKL DAVICVPATL LSRAAETLEG 

        70         80         90        100        110        120 
ETVGLGGQDA HFKTSGAHTG DISPEMLKEA GATHVILGHS ERRTDHHESN KLICAKTEAA 

       130        140        150        160        170        180 
WAAGLVAIVC VGETASERKA ERALDVIGDQ LSGSLPDGVT AENTIIAYEP VWAIGTGLTP 

       190        200        210        220        230        240 
TVQDVRAAHA FMREQLIERF GAKGAHLRLL YGGSVKPSNA AELLGVADVD GALVGGASLK 

       250 
AADFLAICET YRNL

« Hide

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References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941 / Biovar 1.

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Cross-references

Sequence databases

AE017223 Genomic DNA. Translation: AAX74483.1.
RefSeqYP_221844.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3339730.
GenomeReviewsGene locus BruAb1_1144 in contig AE017223_GR.
KEGGbmb:BruAb1_1144.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ57D01.
OMAIGAQDCH.

Enzyme and pathway databases

BioCycBABO262698:BRUAB1_1144-MON.
BRENDA5.3.1.1. 575.

Family and domain databases

HAMAPMF_00147.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR000652. Triosephosphate_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR21139. Triophos_ismrse. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
ProDomPD001005. Triophos_ismrse. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00419. tim. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTPIS1_BRUAB
AccessionPrimary (citable) accession number: Q57D01
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: May 10, 2005
Last modified: November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents