Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q57CU2

- Q57CU2_BRUAB

UniProt

Q57CU2 - Q57CU2_BRUAB

Protein

Isocitrate dehydrogenase [NADP]

Gene

BruAb1_1204

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysis
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi308 – 3136NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-1226-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:BruAb1_1204Imported
    OrganismiBrucella abortus biovar 1 (strain 9-941)Imported
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1204.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57CU2.
    SMRiQ57CU2. Positions 3-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57CU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDIDLK YYDLSVENRD    50
    ATNDQVTIDA ANAIKEYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR 100
    NILGGVIFRE PIICKNVPRL VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG 150
    TLTIKFVGED GQTIEHEVYQ APSAGVAMAM YNLDESIREF ARASFNYGLQ 200
    RGYPVYLSTK NTILKAYDGR FKDIFQEVFD AEFKSKFEEK KIWYEHRLID 250
    DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 300
    VEAEAAHGTV TRHYRQHQKG EETSTNSIAS IFAWTRGLAH RAKLDNNADL 350
    KKFAETLEKV CVDTVESGFM TKDLALLIGP DQPWLSTTGF LDKIDENLQK 400
    AMAA 404
    Length:404
    Mass (Da):45,455
    Last modified:May 10, 2005 - v1
    Checksum:i453241CC1A59DC48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74542.1.
    RefSeqiYP_221903.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74542; AAX74542; BruAb1_1204.
    GeneIDi3340712.
    KEGGibmb:BruAb1_1204.
    PATRICi17824094. VBIBruAbo15061_1269.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74542.1 .
    RefSeqi YP_221903.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57CU2.
    SMRi Q57CU2. Positions 3-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74542 ; AAX74542 ; BruAb1_1204 .
    GeneIDi 3340712.
    KEGGi bmb:BruAb1_1204.
    PATRICi 17824094. VBIBruAbo15061_1269.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-1226-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941Imported.

    Entry informationi

    Entry nameiQ57CU2_BRUAB
    AccessioniPrimary (citable) accession number: Q57CU2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3