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Q57C78 (MURG_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BruAb1_1426
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000225035

Sequences

Sequence LengthMass (Da)Tools
Q57C78 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: B06F854258617F32

FASTA37940,198
        10         20         30         40         50         60 
MDNLANQGVI VLAAGGTGGH LFPAEALAHE LRARGWDVHL ATDARAQRFV GAFAQDHVHV 

        70         80         90        100        110        120 
IRSATIAGRN PVALLKTFWS LWQGNLDSRK LFRRLKPKLV VGFGGYPTLP PLYAASNMGI 

       130        140        150        160        170        180 
PTLIHEQNAV MGRANKGLAG RVKAIAGGFL PENSGAYAAK TVITGNPVRS PVLVAAATPY 

       190        200        210        220        230        240 
TPAGKDDRFR LLVFGGSQGA QFFSQAIPAA VALLPEHERA RLLITQQARK EDEASARQAY 

       250        260        270        280        290        300 
EKLGVPADVA PFFNDMPARM ADAHFVIARS GASTVSEITV IGRPAMLVPF PHALDHDQAA 

       310        320        330        340        350        360 
NAAALAAAGG AEVVRQADLS PQRLAEMLQS AMNEPERLEQ QAKAAKSVGK PDAARLLADL 

       370 
AEAIASGKTV QEFKEGNRP

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017223 Genomic DNA. Translation: AAX74756.1.
RefSeqYP_222117.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57C78.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3340498.
GenomeReviewsGene locus BruAb1_1426 in contig AE017223_GR.
KEGGbmb:BruAb1_1426.
PATRIC17824587. VBIBruAbo15061_1509.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
PhylomeDBQ57C78.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBABO262698:BRUAB1_1426-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BRUAB
AccessionPrimary (citable) accession number: Q57C78
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 10, 2005
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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