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Q57BX7

- APT_BRUAB

UniProt

Q57BX7 - APT_BRUAB

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Protein

Adenine phosphoribosyltransferase

Gene

apt

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. adenine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. adenine salvage Source: InterPro
  2. AMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1560-MONOMER.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.7UniRule annotation)
Short name:
APRTUniRule annotation
Gene namesi
Name:aptUniRule annotation
Ordered Locus Names:BruAb1_1529
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Adenine phosphoribosyltransferasePRO_0000321340Add
BLAST

Proteomic databases

PRIDEiQ57BX7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_1529.

Structurei

3D structure databases

ProteinModelPortaliQ57BX7.
SMRiQ57BX7. Positions 8-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000036776.
KOiK00759.
OMAiTIEIHID.
OrthoDBiEOG6T4S55.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57BX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESGFKVTLK DAIRTIPDYP KPGVQFRDVT TLMGNAQAFR RAVDELVYPY
60 70 80 90 100
AGNRIDKVAG IEARGFILGG AIAHQLSAGF VPIRKKGKLP RDTVRIAYSL
110 120 130 140 150
EYGVDEMEMH RDAIEKGERV VLVDDLIATG GTAEAAAKLL LQMGAEIVAA
160 170 180
CFIIDLPDLG GRKKLEALGL PVRTLVAFEG D
Length:181
Mass (Da):19,614
Last modified:February 26, 2008 - v2
Checksum:i128ABF9D88C2A953
GO

Sequence cautioni

The sequence AAX74857.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74857.1. Different initiation.
RefSeqiYP_222218.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74857; AAX74857; BruAb1_1529.
GeneIDi3341066.
KEGGibmb:BruAb1_1529.
PATRICi17824806. VBIBruAbo15061_1617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74857.1 . Different initiation.
RefSeqi YP_222218.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57BX7.
SMRi Q57BX7. Positions 8-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_1529.

Proteomic databases

PRIDEi Q57BX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX74857 ; AAX74857 ; BruAb1_1529 .
GeneIDi 3341066.
KEGGi bmb:BruAb1_1529.
PATRICi 17824806. VBIBruAbo15061_1617.

Phylogenomic databases

eggNOGi COG0503.
HOGENOMi HOG000036776.
KOi K00759.
OMAi TIEIHID.
OrthoDBi EOG6T4S55.

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00646 .
BioCyci BABO262698:GJC2-1560-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_00004. Aden_phosphoribosyltr.
InterProi IPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01090. apt. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiAPT_BRUAB
AccessioniPrimary (citable) accession number: Q57BX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3