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Q57BX7 (APT_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenine phosphoribosyltransferase

Short name=APRT
EC=2.4.2.7
Gene names
Name:apt
Ordered Locus Names:BruAb1_1529
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004

Catalytic activity

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00004

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00004.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Sequence caution

The sequence AAX74857.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processAMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

adenine salvage

Inferred from electronic annotation. Source: InterPro

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Adenine phosphoribosyltransferase HAMAP-Rule MF_00004
PRO_0000321340

Sequences

Sequence LengthMass (Da)Tools
Q57BX7 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 128ABF9D88C2A953

FASTA18119,614
        10         20         30         40         50         60 
MESGFKVTLK DAIRTIPDYP KPGVQFRDVT TLMGNAQAFR RAVDELVYPY AGNRIDKVAG 

        70         80         90        100        110        120 
IEARGFILGG AIAHQLSAGF VPIRKKGKLP RDTVRIAYSL EYGVDEMEMH RDAIEKGERV 

       130        140        150        160        170        180 
VLVDDLIATG GTAEAAAKLL LQMGAEIVAA CFIIDLPDLG GRKKLEALGL PVRTLVAFEG 


D 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX74857.1. Different initiation.
RefSeqYP_222218.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57BX7.
SMRQ57BX7. Positions 8-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1529.

Proteomic databases

PRIDEQ57BX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX74857; AAX74857; BruAb1_1529.
GeneID3341066.
KEGGbmb:BruAb1_1529.
PATRIC17824806. VBIBruAbo15061_1617.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
HOGENOMHOG000036776.
KOK00759.
OMAYGLEYGK.
OrthoDBEOG6T4S55.
ProtClustDBPRK02304.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1560-MONOMER.
UniPathwayUPA00588; UER00646.

Family and domain databases

HAMAPMF_00004. Aden_phosphoribosyltr.
InterProIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01090. apt. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPT_BRUAB
AccessionPrimary (citable) accession number: Q57BX7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names