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Q57BH8 (RUVB_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holliday junction ATP-dependent DNA helicase RuvB

EC=3.6.4.12
Gene names
Name:ruvB
Ordered Locus Names:BruAb1_1687
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing By similarity. HAMAP-Rule MF_00016

Catalytic activity

ATP + H2O = ADP + phosphate. HAMAP-Rule MF_00016

Subunit structure

Forms a complex with RuvA By similarity. HAMAP-Rule MF_00016

Sequence similarities

Belongs to the RuvB family.

Ontologies

Keywords
   Biological processDNA damage
DNA recombination
DNA repair
SOS response
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA recombination

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

SOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA binding

Inferred from electronic annotation. Source: InterPro

four-way junction helicase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Holliday junction ATP-dependent DNA helicase RuvB HAMAP-Rule MF_00016
PRO_0000235351

Regions

Nucleotide binding59 – 668ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q57BH8 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: E6671068908197AC

FASTA34638,241
        10         20         30         40         50         60 
MSDRNPLIDA DRRADEDNTL RPQTLDDFVG QAAARANLKV FIEAAKVRGE ALDHVLFVGP 

        70         80         90        100        110        120 
PGLGKTTLAQ IMAKELGVNF RSTSGPVIAK AGDLAALLTN LEERDVLFID EIHRLSPAVE 

       130        140        150        160        170        180 
EILYPAMEDF QLDLIIGEGP AARSVKIDLA KFTLVAATTR LGLLTTPLRD RFGIPVRLNF 

       190        200        210        220        230        240 
YTVEELEYIV RRGARIMQMG ISSDGAREVA RRSRGTPRIA GRLLRRVRDF ALVAGADIID 

       250        260        270        280        290        300 
RRIADEALSR LEVDNRGLDQ LDRRYLNIIA RNFGGGPVGI ETIAAGLSEP RDAIEDIIEP 

       310        320        330        340 
YLIQQGFLQR TPRGRVLTAV AWQHLGLPAP AEIIQQSQYG LFMEDE 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX75006.1.
RefSeqYP_222367.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57BH8.
SMRQ57BH8. Positions 19-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1687.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75006; AAX75006; BruAb1_1687.
GeneID3339647.
KEGGbmb:BruAb1_1687.
PATRIC17825158. VBIBruAbo15061_1781.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2255.
HOGENOMHOG000218623.
KOK03551.
OMANGYLERT.
OrthoDBEOG6SR93S.
ProtClustDBPRK00080.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1727-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00016. DNA_helic_RuvB.
InterProIPR003593. AAA+_ATPase.
IPR000641. CbxX_CfqX.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
PRINTSPR00819. CBXCFQXSUPER.
ProDomPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00635. ruvB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVB_BRUAB
AccessionPrimary (citable) accession number: Q57BH8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names