Q57BC4 (THIB_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine-binding periplasmic protein

Gene names

Name:	thiB
Ordered Locus Names:	BruAb1_1742

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex thiBPQ involved in thiamine import By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (thiQ), two transmembrane proteins (thiP) and a solute-binding protein (thiB) Probable.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the bacterial solute-binding protein 1 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Periplasm
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 334	311	Thiamine-binding periplasmic protein		PRO_0000282911

Sequences

	Sequence		Length	Mass (Da)
	Q57BC4 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: C8257889CA07F8D3	FASTA	334	36,752
	10 20 30 40 50 60 MRLLSLLTFS LFAVIGLAPA AQAKDKLTIY TYDSFVSEWG PGPKVKENFE KECDCEVNFV 70 80 90 100 110 120 ASADGVALLN RLKLEGSKTA ADIVLGLDTN LTTEARASGF FAPSGIDQTN VKVPGNFKDD 130 140 150 160 170 180 IFVPYDYGYF AVVYDSEKLP NPPKSLKELV EGDPAQKIVL QDPRTATPGL GMLLWMKSVY 190 200 210 220 230 240 GDEAGAAWQK LQKRVLTVTP GWSEAYGLFT KGEAPMVLSY TTSPAYHMVV EKTDRYKALA 250 260 270 280 290 300 YPEGNYLQIE LAAQTTTGAK NPLAKKFLAF MTGPGFQDLI PETNWMFPAG KTSKPLPAAF 310 320 330 DALPKPEKTL LIPPYEVAKN RRLWVNEWLA ATSR

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX75060.1.
RefSeq	YP_222421.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q57BC4.
SMR	Q57BC4. Positions 24-333.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3340057.
GenomeReviews	Gene locus BruAb1_1742 in contig AE017223_GR.
KEGG	bmb:BruAb1_1742.
PATRIC	17825269. VBIBruAbo15061_1836.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG476839.
OMA	IPTTNWM.
PhylomeDB	Q57BC4.
ProtClustDB	PRK11205.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_1742-MONOMER.
Family and domain databases
InterPro	IPR006059. Solute-bd_1_bac. IPR005948. Thi_ABC_peri-bd. IPR005967. ThiB_ABC_peri-bd. [Graphical view]
KO	K02064.
Pfam	PF01547. SBP_bac_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01254. SfuA. 1 hit. TIGR01276. ThiB. 1 hit.
PROSITE	PS01037. SBP_BACTERIAL_1. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIB_BRUAB

Accession

Primary (citable) accession number: Q57BC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	May 10, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program