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Protein

Thiamine import ATP-binding protein ThiQ

Gene

thiQ

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thiamine-transporting ATPase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1784-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine import ATP-binding protein ThiQUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:thiQUniRule annotation
Ordered Locus Names:BruAb1_1744
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Thiamine import ATP-binding protein ThiQPRO_0000274433Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_1744.

Structurei

3D structure databases

ProteinModelPortaliQ57BC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 235229ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG3840.
KOiK02062.
OMAiHELHRTH.
OrthoDBiEOG6SNDS1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005968. Thiamine_ABC_ThiQ.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01277. thiQ. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51288. THIQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57BC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTASADIRLS DVRFSYGETA MHFDVTITGG EIAAIVGPSG SGKSTFLNLI
60 70 80 90 100
AGFETPQSGI ISINGVDVTH LPLADRPVSM VFQENNLFAH LTVEQNVDLG
110 120 130 140 150
RSPNLRLNEE DRKAVASALA RVGLQGKEKR KPEALSGGER QRVAIARVLV
160 170 180 190 200
RERPVLLLDE AFASLGPALR HQMLDLVNKL RRETGMTVLM VTHTPEDALH
210 220 230 240
LDALLIFLDN GKIAAQGPAT EMLSRAGPEA LRHYIGEMRS F
Length:241
Mass (Da):26,187
Last modified:May 10, 2005 - v1
Checksum:i07D827263C8FE98D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75062.1.
RefSeqiYP_222423.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75062; AAX75062; BruAb1_1744.
GeneIDi3340059.
KEGGibmb:BruAb1_1744.
PATRICi17825273. VBIBruAbo15061_1838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75062.1.
RefSeqiYP_222423.1. NC_006932.1.

3D structure databases

ProteinModelPortaliQ57BC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_1744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75062; AAX75062; BruAb1_1744.
GeneIDi3340059.
KEGGibmb:BruAb1_1744.
PATRICi17825273. VBIBruAbo15061_1838.

Phylogenomic databases

eggNOGiCOG3840.
KOiK02062.
OMAiHELHRTH.
OrthoDBiEOG6SNDS1.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1784-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005968. Thiamine_ABC_ThiQ.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01277. thiQ. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51288. THIQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiTHIQ_BRUAB
AccessioniPrimary (citable) accession number: Q57BC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.