ATP synthase subunit alpha - Brucella abortus biovar 1 (strain 9-941)

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Q57B86 (ATPA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 68. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ATP synthase subunit alpha
EC=3.6.3.14

Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha

Gene names

Name:	atpA
Ordered Locus Names:	BruAb1_1781

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP-Rule MF_01346
Catalytic activity	ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out). HAMAP-Rule MF_01346
Subunit structure	F-type ATPases have 2 components, CF₁ - the catalytic core - and CF₀ - the membrane proton channel. CF₁ has five subunits: alpha₃, beta₃, gamma₁, delta₁, epsilon₁. CF₀ has three main subunits: a₁, b₂ and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF₁ is attached to CF₀ by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01346.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP proton-transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 509

509

ATP synthase subunit alpha HAMAP-Rule MF_01346

PRO_0000238213

Regions

Nucleotide binding

169 – 176

ATP By similarity

Sites

Site

370

Required for activity By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q57B86 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 954BCF9B79649E62
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FASTA

509

54,970

        10         20         30         40         50         60 
MDIRAAEISA ILKEQIKNFG KEAEVSEVGQ VLSVGDGIAR VYGLDNVQAG EMVEFPGGIR 

        70         80         90        100        110        120 
GMALNLESDN VGVVIFGADR DIKEGDVVKR TGAIVDVPVG PELLGRVVDA LGNPIDGKGP 

       130        140        150        160        170        180 
IKAKERRRVD VKAPGIIPRK SVHEPMSTGL KAIDALIPVG RGQRELVIGD RQTGKTAIIL 

       190        200        210        220        230        240 
DTFLNQKPIH DNGPDKDKLY CVYVAVGQKR STVAQFVKVL EERGALEYSI VVAATASDPA 

       250        260        270        280        290        300 
PMQYLAPFAG CAMGEYFRDN GQHALIGYDD LSKQAVAYRQ MSLLLRRPPG REAYPGDVFY 

       310        320        330        340        350        360 
LHSRLLERAA KLNDENGAGS LTALPVIETQ GNDVSAFIPT NVISITDGQI FLETNLFYQG 

       370        380        390        400        410        420 
IRPAVNVGLS VSRVGSSAQI KAMKQVAGSI KGELAQYREM AAFAQFGSDL DAATQRLLNR 

       430        440        450        460        470        480 
GARLTELLKQ PQFSPLKTEE QVAVIYAGVN GYLDKLAVNQ VGKFEEGLLA SLRTEHKDVL 

       490        500 
EGIRNEKALT DDLKAKLKAA IDAFAKSFV

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References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX75098.1.
RefSeq	YP_222459.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q57B86.
SMR	Q57B86. Positions 24-501.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1781.
Proteomic databases
PRIDE	Q57B86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX75098; AAX75098; BruAb1_1781.
GeneID	3340999.
KEGG	bmb:BruAb1_1781.
PATRIC	17825353. VBIBruAbo15061_1878.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0056.
HOGENOM	HOG000130111.
KO	K02111.
OMA	GSDRDIK.
ProtClustDB	PRK09281.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-1821-MONOMER.
Family and domain databases
Gene3D	2.40.30.20. 1 hit.
HAMAP	MF_01346. ATP_synth_alpha_bact.
InterPro	IPR020003. ATPase_a/bsu_AS. IPR004100. ATPase_a/bsu_N. IPR005294. ATPase_F1-cplx_asu. IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR15184:SF3. PTHR15184:SF3. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SUPFAM	SSF47917. ATPase_a/b_C. 1 hit. SSF50615. ATPase_a/b_N. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00962. atpA. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATPA_BRUAB

Accession

Primary (citable) accession number: Q57B86

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 10, 2005
Last modified:	May 29, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents