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Q57B86

- ATPA_BRUAB

UniProt

Q57B86 - ATPA_BRUAB

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Protein

ATP synthase subunit alpha

Gene
atpA, BruAb1_1781
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3701Required for activity By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATPase activity, rotational mechanism Source: InterPro
  3. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1821-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alpha (EC:3.6.3.14)
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene namesi
Name:atpA
Ordered Locus Names:BruAb1_1781
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
  2. proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509ATP synthase subunit alphaUniRule annotationPRO_0000238213Add
BLAST

Proteomic databases

PRIDEiQ57B86.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Protein-protein interaction databases

STRINGi262698.BruAb1_1781.

Structurei

3D structure databases

ProteinModelPortaliQ57B86.
SMRiQ57B86. Positions 24-501.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0056.
HOGENOMiHOG000130111.
KOiK02111.
OMAiIRPSEIS.
OrthoDBiEOG67X1S1.

Family and domain databases

Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57B86-1 [UniParc]FASTAAdd to Basket

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MDIRAAEISA ILKEQIKNFG KEAEVSEVGQ VLSVGDGIAR VYGLDNVQAG    50
EMVEFPGGIR GMALNLESDN VGVVIFGADR DIKEGDVVKR TGAIVDVPVG 100
PELLGRVVDA LGNPIDGKGP IKAKERRRVD VKAPGIIPRK SVHEPMSTGL 150
KAIDALIPVG RGQRELVIGD RQTGKTAIIL DTFLNQKPIH DNGPDKDKLY 200
CVYVAVGQKR STVAQFVKVL EERGALEYSI VVAATASDPA PMQYLAPFAG 250
CAMGEYFRDN GQHALIGYDD LSKQAVAYRQ MSLLLRRPPG REAYPGDVFY 300
LHSRLLERAA KLNDENGAGS LTALPVIETQ GNDVSAFIPT NVISITDGQI 350
FLETNLFYQG IRPAVNVGLS VSRVGSSAQI KAMKQVAGSI KGELAQYREM 400
AAFAQFGSDL DAATQRLLNR GARLTELLKQ PQFSPLKTEE QVAVIYAGVN 450
GYLDKLAVNQ VGKFEEGLLA SLRTEHKDVL EGIRNEKALT DDLKAKLKAA 500
IDAFAKSFV 509
Length:509
Mass (Da):54,970
Last modified:May 10, 2005 - v1
Checksum:i954BCF9B79649E62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75098.1.
RefSeqiYP_222459.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75098; AAX75098; BruAb1_1781.
GeneIDi3340999.
KEGGibmb:BruAb1_1781.
PATRICi17825353. VBIBruAbo15061_1878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75098.1 .
RefSeqi YP_222459.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57B86.
SMRi Q57B86. Positions 24-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_1781.

Proteomic databases

PRIDEi Q57B86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75098 ; AAX75098 ; BruAb1_1781 .
GeneIDi 3340999.
KEGGi bmb:BruAb1_1781.
PATRICi 17825353. VBIBruAbo15061_1878.

Phylogenomic databases

eggNOGi COG0056.
HOGENOMi HOG000130111.
KOi K02111.
OMAi IRPSEIS.
OrthoDBi EOG67X1S1.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-1821-MONOMER.

Family and domain databases

Gene3Di 2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01346. ATP_synth_alpha_bact.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00962. atpA. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiATPA_BRUAB
AccessioniPrimary (citable) accession number: Q57B86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 10, 2005
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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