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Q57B48 (NADD_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable nicotinate-nucleotide adenylyltransferase

EC=2.7.7.18
Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase
Gene names
Name:nadD
Ordered Locus Names:BruAb1_1821
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244

Catalytic activity

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244

Sequence similarities

Belongs to the NadD family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandATP-binding
NAD
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nicotinate-nucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244
PRO_0000181394

Sequences

Sequence LengthMass (Da)Tools
Q57B48 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 9615792D51B51580

FASTA19421,977
        10         20         30         40         50         60 
MTVGLFGGSF NPPHGGHALV AEIAIRRLKL DQLWWMVTPG NPLKDSRELA PLSERLRLSE 

        70         80         90        100        110        120 
EVAEDPRIKV TALEAAFHVR YTADTLALIR NANPDVYFVW VMGADNLASF HRWQRWREIA 

       130        140        150        160        170        180 
QNFPIAIIDR PGSTLSYLSS RMAQTFSDSR LDERYAPVLA RRMPPAWTFI HGPRSSLSST 

       190 
ALRKVQLKKA PSKK 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX75136.1.
RefSeqYP_222497.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57B48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75136; AAX75136; BruAb1_1821.
GeneID3340399.
KEGGbmb:BruAb1_1821.
PATRIC17825447. VBIBruAbo15061_1925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1057.
HOGENOMHOG000262782.
KOK00969.
OMAWWLVTPG.
OrthoDBEOG6F55KJ.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1861-MONOMER.
UniPathwayUPA00253; UER00332.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00244. NaMN_adenylyltr.
InterProIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00482. TIGR00482. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADD_BRUAB
AccessionPrimary (citable) accession number: Q57B48
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names