Q57B48 (NADD_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable nicotinate-nucleotide adenylyltransferase
EC=2.7.7.18

Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase

Gene names

Name:	nadD
Ordered Locus Names:	BruAb1_1821

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244
Catalytic activity	ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244
Sequence similarities	Belongs to the NadD family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244		PRO_0000181394

Sequences

	Sequence		Length	Mass (Da)
	Q57B48 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 9615792D51B51580	FASTA	194	21,977
	10 20 30 40 50 60 MTVGLFGGSF NPPHGGHALV AEIAIRRLKL DQLWWMVTPG NPLKDSRELA PLSERLRLSE 70 80 90 100 110 120 EVAEDPRIKV TALEAAFHVR YTADTLALIR NANPDVYFVW VMGADNLASF HRWQRWREIA 130 140 150 160 170 180 QNFPIAIIDR PGSTLSYLSS RMAQTFSDSR LDERYAPVLA RRMPPAWTFI HGPRSSLSST 190 ALRKVQLKKA PSKK

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX75136.1.
RefSeq	YP_222497.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q57B48.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1821.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX75136; AAX75136; BruAb1_1821.
GeneID	3340399.
KEGG	bmb:BruAb1_1821.
PATRIC	17825447. VBIBruAbo15061_1925.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1057.
HOGENOM	HOG000262782.
KO	K00969.
OMA	YLHGPLS.
ProtClustDB	PRK00071.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-1861-MONOMER.
UniPathway	UPA00253; UER00332.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00244. NaMN_adenylyltr.
InterPro	IPR004821. Cyt_trans-like. IPR005248. NAMN_adtrnsfrase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00482. TIGR00482. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADD_BRUAB

Accession

Primary (citable) accession number: Q57B48

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program