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Reviewed, UniProtKB/Swiss-Prot Q57B07 (GCP_BRUAB)

Last modified February 9, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57
Gene names
Name: gcp
Ordered Locus Names: BruAb1_1865
OrganismBrucella abortus [Complete proteome] [HAMAP]
Taxonomic identifier235 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445

Cofactor

Zinc Probable. HAMAP MF_01445

Sequence similarities

Belongs to the peptidase M22 family.

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Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445
PRO_0000303293

Sites

Metal binding1151Zinc Potential
Metal binding1191Zinc Potential

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Sequences

Sequence LengthMass (Da)Tools
Q57B07-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 78EB27EF0DCE9369

FASTA35938,013
        10         20         30         40         50         60 
MRVLGIETSC DETAAAIVER DDMGEGRILS NVVLSQIAEH EPYGGVVPEI AARAHVEALD 

        70         80         90        100        110        120 
RLVDRALNDA GLKLYEVDAV AATAGPGLIG GLIVGLMTAK ALAMAAQKPF YAVNHLEGHA 

       130        140        150        160        170        180 
LTARLTDGLP FPYLLLLVSG GHTQMVLVRG IGDYERLGTT IDDALGEAFD KTAKLLGLPY 

       190        200        210        220        230        240 
PGGPTVERMA LQGDQKRFAL PRPLKGEARL DFSFSGLKTA VRQTATELVP LTDQDVTDIC 

       250        260        270        280        290        300 
ASFQAAVADT LSDRVGRSLE RFKTEFPDCA TPSLVVAGGV AANKTLRAAL ENLCTRHGFA 

       310        320        330        340        350 
FIAPPLNLCT DNAAMIAWAG AERAATQAPD SLDIAPRSRW PLDEKSAPVF GTGRRGAKA

« Hide

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References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941 / Biovar 1.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017223 Genomic DNA. Translation: AAX75177.1.
RefSeqYP_222538.1.

3D structure databases

SMRQ57B07. Positions 1-348.
ModBaseSearch...

Protein family/group databases

MEROPSM22.001.

Genome annotation databases

GeneID3340228.
GenomeReviewsGene locus BruAb1_1865 in contig AE017223_GR.
KEGGbmb:BruAb1_1865.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG304663.
OMACKRALKQ.
PhylomeDBQ57B07.

Enzyme and pathway databases

BioCycBABO262698:BRUAB1_1865-MONOMER.
BRENDA3.4.24.57. 575.

Family and domain databases

HAMAPMF_01445. Glycoptase_bact.
[Tree]
InterProIPR009180. Pept_M22_O-sialoglycoprot.
IPR000905. Peptidase_M22.
IPR017861. Peptidase_M22_subgr.
[Graphical view]
PANTHERPTHR11735. Pept_M22_Osialgl. 1 hit.
PfamPF00814. Peptidase_M22. 1 hit.
[Graphical view]
PRINTSPR00789. OSIALOPTASE.
TIGRFAMsTIGR00329. gcp. 1 hit.
PROSITEPS01016. GLYCOPROTEASE. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGCP_BRUAB
AccessionPrimary (citable) accession number: Q57B07
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 10, 2005
Last modified: February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents