Q57AV4 (SECA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein translocase subunit SecA

Gene names

Name:	secA
Ordered Locus Names:	BruAb1_1921

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	906 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382
Cofactor	May bind 1 zinc ion per subunit Potential.
Subunit structure	Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity. HAMAP-Rule MF_01382
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382
Sequence similarities	Belongs to the SecA family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein import Inferred from electronic annotation. Source: InterPro protein targeting Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 906	906	Protein translocase subunit SecA HAMAP-Rule MF_01382		PRO_1000073464
Regions
	Nucleotide binding	104 – 111	8	ATP Potential
Sites
	Metal binding	890	1	Zinc Potential
	Metal binding	892	1	Zinc Potential
	Metal binding	901	1	Zinc Potential
	Metal binding	902	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57AV4 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 5D608191D2F3CFE1	FASTA	906	102,871
	10 20 30 40 50 60 MVSFGGLARK IFGSSNDRRV KTLRQRAEQI TALEKNYENL TDEQLQAKTA EFRAALAEGK 70 80 90 100 110 120 SLDSLLPDAF ATAREAAKRV LGMRPFDVQL IGGMVLHERG IAEMRTGEGK TLMATLPVYL 130 140 150 160 170 180 NALEGKGVHV VTVNDYLATR DAETMGRLYN FLGLTVGVIK HGLDDDERRA AYACDITYGT 190 200 210 220 230 240 NNELGFDYLR DNMKYERAQM VQRPHNYAIV DEVDSILIDE ARTPLIISGP LEDRSDFYNL 250 260 270 280 290 300 IDTFIPPLAE EDYEVDEKQK TAIFTEVGTE KVEKLLEAAG HLKGESLYDI ENVAVVHHLN 310 320 330 340 350 360 NALRAHKLFQ RDKDYIVRND EIVIIDEFTG RMMPGRRYSE GLHQALEAKE HVTIQPENQT 370 380 390 400 410 420 LASITFQNYF RMYNKLSGMT GTAATEAEEF GNIYGLEVLE IPTNLPVQRI DEDDEVYRTV 430 440 450 460 470 480 EEKYRAIVRD IRASHEKGQP ILVGTTSIEK SEQLAERLRR EGIKGFQVLN ARYHEQEAYI 490 500 510 520 530 540 IAQAGVPGAV TIATNMAGRG TDIQLGGNLE MRVRQELSDV PEGPEREEKI AAIKADIAQL 550 560 570 580 590 600 KEKALAAGGL YVLATERHES RRIDNQLRGR SGRQGDPGRS KFFLSLQDDL MRIFGSDRMD 610 620 630 640 650 660 GMLQKLGLKE DEAIVHPWIN KALEKAQKKV EARNFEIRKN LLKYDDVMND QRKVIFEQRL 670 680 690 700 710 720 EMMDEEDLTE TVAEMRHEVI EDMVILRIPK DAYAEKWDIA GLKQDIASKL NLDLPVEEWA 730 740 750 760 770 780 KEEGIAEEEF ENRIKEAADK AAAEKAERFG PQIMTYVEKS VIMQSLDNLW REHLVNLDHL 790 800 810 820 830 840 RSVVGFRGYA QRDPLNEYKT EAFELFQTML ANLREVVISQ LMRVEIVREA PPEPQLPPMA 850 860 870 880 890 900 GLHIDGTTGE NDFDEAIWAE HQHDDRIVPP AQRDPADPRT WGKVSRNEPC PCGSGKKYKH CHGAFE

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX75230.1.
RefSeq	YP_222591.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q57AV4.
SMR	Q57AV4. Positions 16-236.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1921.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX75230; AAX75230; BruAb1_1921.
GeneID	3340541.
KEGG	bmb:BruAb1_1921.
PATRIC	17825671. VBIBruAbo15061_2028.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0653.
HOGENOM	HOG000218168.
KO	K03070.
OMA	ERFFILQ.
ProtClustDB	PRK12904.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-1968-MONOMER.
Family and domain databases
Gene3D	1.10.3060.10. 1 hit. 3.90.1440.10. 1 hit.
HAMAP	MF_01382. SecA.
InterPro	IPR027417. P-loop_NTPase. IPR004027. SEC_C_motif. IPR000185. SecA. IPR020937. SecA_CS. IPR011115. SecA_DEAD. IPR014018. SecA_motor_DEAD. IPR011130. SecA_preprotein_X-link_dom. IPR011116. SecA_Wing/Scaffold. [Graphical view]
Pfam	PF02810. SEC-C. 1 hit. PF07517. SecA_DEAD. 1 hit. PF01043. SecA_PP_bind. 1 hit. PF07516. SecA_SW. 1 hit. [Graphical view]
PRINTS	PR00906. SECA.
SMART	SM00957. SecA_DEAD. 1 hit. SM00958. SecA_PP_bind. 1 hit. [Graphical view]
SUPFAM	SSF81767. SecA_PP_bd. 1 hit. SSF81886. SecA_SW. 1 hit. SSF52540. SSF52540. 2 hits.
TIGRFAMs	TIGR00963. secA. 1 hit.
PROSITE	PS01312. SECA. 1 hit. PS51196. SECA_MOTOR_DEAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SECA_BRUAB

Accession

Primary (citable) accession number: Q57AV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 10, 2005
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program