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Q57AV4 (SECA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein translocase subunit SecA
Gene names
Name:secA
Ordered Locus Names:BruAb1_1921
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length906 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382

Cofactor

May bind 1 zinc ion per subunit Potential.

Subunit structure

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity. HAMAP-Rule MF_01382

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382

Sequence similarities

Belongs to the SecA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 906906Protein translocase subunit SecA HAMAP-Rule MF_01382
PRO_1000073464

Regions

Nucleotide binding104 – 1118ATP Potential

Sites

Metal binding8901Zinc Potential
Metal binding8921Zinc Potential
Metal binding9011Zinc Potential
Metal binding9021Zinc Potential

Sequences

Sequence LengthMass (Da)Tools
Q57AV4 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 5D608191D2F3CFE1

FASTA906102,871
        10         20         30         40         50         60 
MVSFGGLARK IFGSSNDRRV KTLRQRAEQI TALEKNYENL TDEQLQAKTA EFRAALAEGK 

        70         80         90        100        110        120 
SLDSLLPDAF ATAREAAKRV LGMRPFDVQL IGGMVLHERG IAEMRTGEGK TLMATLPVYL 

       130        140        150        160        170        180 
NALEGKGVHV VTVNDYLATR DAETMGRLYN FLGLTVGVIK HGLDDDERRA AYACDITYGT 

       190        200        210        220        230        240 
NNELGFDYLR DNMKYERAQM VQRPHNYAIV DEVDSILIDE ARTPLIISGP LEDRSDFYNL 

       250        260        270        280        290        300 
IDTFIPPLAE EDYEVDEKQK TAIFTEVGTE KVEKLLEAAG HLKGESLYDI ENVAVVHHLN 

       310        320        330        340        350        360 
NALRAHKLFQ RDKDYIVRND EIVIIDEFTG RMMPGRRYSE GLHQALEAKE HVTIQPENQT 

       370        380        390        400        410        420 
LASITFQNYF RMYNKLSGMT GTAATEAEEF GNIYGLEVLE IPTNLPVQRI DEDDEVYRTV 

       430        440        450        460        470        480 
EEKYRAIVRD IRASHEKGQP ILVGTTSIEK SEQLAERLRR EGIKGFQVLN ARYHEQEAYI 

       490        500        510        520        530        540 
IAQAGVPGAV TIATNMAGRG TDIQLGGNLE MRVRQELSDV PEGPEREEKI AAIKADIAQL 

       550        560        570        580        590        600 
KEKALAAGGL YVLATERHES RRIDNQLRGR SGRQGDPGRS KFFLSLQDDL MRIFGSDRMD 

       610        620        630        640        650        660 
GMLQKLGLKE DEAIVHPWIN KALEKAQKKV EARNFEIRKN LLKYDDVMND QRKVIFEQRL 

       670        680        690        700        710        720 
EMMDEEDLTE TVAEMRHEVI EDMVILRIPK DAYAEKWDIA GLKQDIASKL NLDLPVEEWA 

       730        740        750        760        770        780 
KEEGIAEEEF ENRIKEAADK AAAEKAERFG PQIMTYVEKS VIMQSLDNLW REHLVNLDHL 

       790        800        810        820        830        840 
RSVVGFRGYA QRDPLNEYKT EAFELFQTML ANLREVVISQ LMRVEIVREA PPEPQLPPMA 

       850        860        870        880        890        900 
GLHIDGTTGE NDFDEAIWAE HQHDDRIVPP AQRDPADPRT WGKVSRNEPC PCGSGKKYKH 


CHGAFE 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX75230.1.
RefSeqYP_222591.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57AV4.
SMRQ57AV4. Positions 16-236.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1921.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75230; AAX75230; BruAb1_1921.
GeneID3340541.
KEGGbmb:BruAb1_1921.
PATRIC17825671. VBIBruAbo15061_2028.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0653.
HOGENOMHOG000218168.
KOK03070.
OMAEFQEIYG.
OrthoDBEOG654P48.
ProtClustDBPRK12904.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1968-MONOMER.

Family and domain databases

Gene3D1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPMF_01382. SecA.
InterProIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSPR00906. SECA.
SMARTSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsTIGR00963. secA. 1 hit.
PROSITEPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSECA_BRUAB
AccessionPrimary (citable) accession number: Q57AV4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names