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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi890ZincUniRule annotation1
Metal bindingi892ZincUniRule annotation1
Metal bindingi901ZincUniRule annotation1
Metal bindingi902ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 111ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:BruAb1_1921
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000734641 – 906Protein translocase subunit SecAAdd BLAST906

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ57AV4
SMRiQ57AV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 2 hits
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q57AV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFGGLARK IFGSSNDRRV KTLRQRAEQI TALEKNYENL TDEQLQAKTA
60 70 80 90 100
EFRAALAEGK SLDSLLPDAF ATAREAAKRV LGMRPFDVQL IGGMVLHERG
110 120 130 140 150
IAEMRTGEGK TLMATLPVYL NALEGKGVHV VTVNDYLATR DAETMGRLYN
160 170 180 190 200
FLGLTVGVIK HGLDDDERRA AYACDITYGT NNELGFDYLR DNMKYERAQM
210 220 230 240 250
VQRPHNYAIV DEVDSILIDE ARTPLIISGP LEDRSDFYNL IDTFIPPLAE
260 270 280 290 300
EDYEVDEKQK TAIFTEVGTE KVEKLLEAAG HLKGESLYDI ENVAVVHHLN
310 320 330 340 350
NALRAHKLFQ RDKDYIVRND EIVIIDEFTG RMMPGRRYSE GLHQALEAKE
360 370 380 390 400
HVTIQPENQT LASITFQNYF RMYNKLSGMT GTAATEAEEF GNIYGLEVLE
410 420 430 440 450
IPTNLPVQRI DEDDEVYRTV EEKYRAIVRD IRASHEKGQP ILVGTTSIEK
460 470 480 490 500
SEQLAERLRR EGIKGFQVLN ARYHEQEAYI IAQAGVPGAV TIATNMAGRG
510 520 530 540 550
TDIQLGGNLE MRVRQELSDV PEGPEREEKI AAIKADIAQL KEKALAAGGL
560 570 580 590 600
YVLATERHES RRIDNQLRGR SGRQGDPGRS KFFLSLQDDL MRIFGSDRMD
610 620 630 640 650
GMLQKLGLKE DEAIVHPWIN KALEKAQKKV EARNFEIRKN LLKYDDVMND
660 670 680 690 700
QRKVIFEQRL EMMDEEDLTE TVAEMRHEVI EDMVILRIPK DAYAEKWDIA
710 720 730 740 750
GLKQDIASKL NLDLPVEEWA KEEGIAEEEF ENRIKEAADK AAAEKAERFG
760 770 780 790 800
PQIMTYVEKS VIMQSLDNLW REHLVNLDHL RSVVGFRGYA QRDPLNEYKT
810 820 830 840 850
EAFELFQTML ANLREVVISQ LMRVEIVREA PPEPQLPPMA GLHIDGTTGE
860 870 880 890 900
NDFDEAIWAE HQHDDRIVPP AQRDPADPRT WGKVSRNEPC PCGSGKKYKH

CHGAFE
Length:906
Mass (Da):102,871
Last modified:May 10, 2005 - v1
Checksum:i5D608191D2F3CFE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA Translation: AAX75230.1
RefSeqiWP_002965012.1, NC_006932.1

Genome annotation databases

EnsemblBacteriaiAAX75230; AAX75230; BruAb1_1921
KEGGibmb:BruAb1_1921

Similar proteinsi

Entry informationi

Entry nameiSECA_BRUAB
AccessioniPrimary (citable) accession number: Q57AV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health