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Q57AV4

- SECA_BRUAB

UniProt

Q57AV4 - SECA_BRUAB

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Protein

Protein translocase subunit SecA

Gene
secA, BruAb1_1921
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity.UniRule annotation

Cofactori

May bind 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi890 – 8901Zinc Reviewed prediction
Metal bindingi892 – 8921Zinc Reviewed prediction
Metal bindingi901 – 9011Zinc Reviewed prediction
Metal bindingi902 – 9021Zinc Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1118ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein import Source: InterPro
  3. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA
Gene namesi
Name:secA
Ordered Locus Names:BruAb1_1921
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: Distribution is 50-50 By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Protein translocase subunit SecAUniRule annotationPRO_1000073464Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_1921.

Structurei

3D structure databases

ProteinModelPortaliQ57AV4.
SMRiQ57AV4. Positions 16-236.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiMPPKTYA.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57AV4-1 [UniParc]FASTAAdd to Basket

« Hide

MVSFGGLARK IFGSSNDRRV KTLRQRAEQI TALEKNYENL TDEQLQAKTA    50
EFRAALAEGK SLDSLLPDAF ATAREAAKRV LGMRPFDVQL IGGMVLHERG 100
IAEMRTGEGK TLMATLPVYL NALEGKGVHV VTVNDYLATR DAETMGRLYN 150
FLGLTVGVIK HGLDDDERRA AYACDITYGT NNELGFDYLR DNMKYERAQM 200
VQRPHNYAIV DEVDSILIDE ARTPLIISGP LEDRSDFYNL IDTFIPPLAE 250
EDYEVDEKQK TAIFTEVGTE KVEKLLEAAG HLKGESLYDI ENVAVVHHLN 300
NALRAHKLFQ RDKDYIVRND EIVIIDEFTG RMMPGRRYSE GLHQALEAKE 350
HVTIQPENQT LASITFQNYF RMYNKLSGMT GTAATEAEEF GNIYGLEVLE 400
IPTNLPVQRI DEDDEVYRTV EEKYRAIVRD IRASHEKGQP ILVGTTSIEK 450
SEQLAERLRR EGIKGFQVLN ARYHEQEAYI IAQAGVPGAV TIATNMAGRG 500
TDIQLGGNLE MRVRQELSDV PEGPEREEKI AAIKADIAQL KEKALAAGGL 550
YVLATERHES RRIDNQLRGR SGRQGDPGRS KFFLSLQDDL MRIFGSDRMD 600
GMLQKLGLKE DEAIVHPWIN KALEKAQKKV EARNFEIRKN LLKYDDVMND 650
QRKVIFEQRL EMMDEEDLTE TVAEMRHEVI EDMVILRIPK DAYAEKWDIA 700
GLKQDIASKL NLDLPVEEWA KEEGIAEEEF ENRIKEAADK AAAEKAERFG 750
PQIMTYVEKS VIMQSLDNLW REHLVNLDHL RSVVGFRGYA QRDPLNEYKT 800
EAFELFQTML ANLREVVISQ LMRVEIVREA PPEPQLPPMA GLHIDGTTGE 850
NDFDEAIWAE HQHDDRIVPP AQRDPADPRT WGKVSRNEPC PCGSGKKYKH 900
CHGAFE 906
Length:906
Mass (Da):102,871
Last modified:May 10, 2005 - v1
Checksum:i5D608191D2F3CFE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75230.1.
RefSeqiYP_222591.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75230; AAX75230; BruAb1_1921.
GeneIDi3340541.
KEGGibmb:BruAb1_1921.
PATRICi17825671. VBIBruAbo15061_2028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75230.1 .
RefSeqi YP_222591.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57AV4.
SMRi Q57AV4. Positions 16-236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_1921.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75230 ; AAX75230 ; BruAb1_1921 .
GeneIDi 3340541.
KEGGi bmb:BruAb1_1921.
PATRICi 17825671. VBIBruAbo15061_2028.

Phylogenomic databases

eggNOGi COG0653.
HOGENOMi HOG000218168.
KOi K03070.
OMAi MPPKTYA.
OrthoDBi EOG654P48.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-1968-MONOMER.

Family and domain databases

Gene3Di 1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPi MF_01382. SecA.
InterProi IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view ]
Pfami PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view ]
PRINTSi PR00906. SECA.
SMARTi SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsi TIGR00963. secA. 1 hit.
PROSITEi PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiSECA_BRUAB
AccessioniPrimary (citable) accession number: Q57AV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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