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Q57AV4

- SECA_BRUAB

UniProt

Q57AV4 - SECA_BRUAB

Protein

Protein translocase subunit SecA

Gene

secA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

    Cofactori

    May bind 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi890 – 8901ZincUniRule annotation
    Metal bindingi892 – 8921ZincUniRule annotation
    Metal bindingi901 – 9011ZincUniRule annotation
    Metal bindingi902 – 9021ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi104 – 1118ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein import Source: InterPro
    3. protein targeting Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-1968-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecAUniRule annotation
    Gene namesi
    Name:secAUniRule annotation
    Ordered Locus Names:BruAb1_1921
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
    Note: Distribution is 50-50.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 906906Protein translocase subunit SecAPRO_1000073464Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1921.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57AV4.
    SMRiQ57AV4. Positions 16-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0653.
    HOGENOMiHOG000218168.
    KOiK03070.
    OMAiMPPKTYA.
    OrthoDBiEOG654P48.

    Family and domain databases

    Gene3Di1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPiMF_01382. SecA.
    InterProiIPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view]
    PfamiPF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view]
    PRINTSiPR00906. SECA.
    SMARTiSM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsiTIGR00963. secA. 1 hit.
    PROSITEiPS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57AV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSFGGLARK IFGSSNDRRV KTLRQRAEQI TALEKNYENL TDEQLQAKTA    50
    EFRAALAEGK SLDSLLPDAF ATAREAAKRV LGMRPFDVQL IGGMVLHERG 100
    IAEMRTGEGK TLMATLPVYL NALEGKGVHV VTVNDYLATR DAETMGRLYN 150
    FLGLTVGVIK HGLDDDERRA AYACDITYGT NNELGFDYLR DNMKYERAQM 200
    VQRPHNYAIV DEVDSILIDE ARTPLIISGP LEDRSDFYNL IDTFIPPLAE 250
    EDYEVDEKQK TAIFTEVGTE KVEKLLEAAG HLKGESLYDI ENVAVVHHLN 300
    NALRAHKLFQ RDKDYIVRND EIVIIDEFTG RMMPGRRYSE GLHQALEAKE 350
    HVTIQPENQT LASITFQNYF RMYNKLSGMT GTAATEAEEF GNIYGLEVLE 400
    IPTNLPVQRI DEDDEVYRTV EEKYRAIVRD IRASHEKGQP ILVGTTSIEK 450
    SEQLAERLRR EGIKGFQVLN ARYHEQEAYI IAQAGVPGAV TIATNMAGRG 500
    TDIQLGGNLE MRVRQELSDV PEGPEREEKI AAIKADIAQL KEKALAAGGL 550
    YVLATERHES RRIDNQLRGR SGRQGDPGRS KFFLSLQDDL MRIFGSDRMD 600
    GMLQKLGLKE DEAIVHPWIN KALEKAQKKV EARNFEIRKN LLKYDDVMND 650
    QRKVIFEQRL EMMDEEDLTE TVAEMRHEVI EDMVILRIPK DAYAEKWDIA 700
    GLKQDIASKL NLDLPVEEWA KEEGIAEEEF ENRIKEAADK AAAEKAERFG 750
    PQIMTYVEKS VIMQSLDNLW REHLVNLDHL RSVVGFRGYA QRDPLNEYKT 800
    EAFELFQTML ANLREVVISQ LMRVEIVREA PPEPQLPPMA GLHIDGTTGE 850
    NDFDEAIWAE HQHDDRIVPP AQRDPADPRT WGKVSRNEPC PCGSGKKYKH 900
    CHGAFE 906
    Length:906
    Mass (Da):102,871
    Last modified:May 10, 2005 - v1
    Checksum:i5D608191D2F3CFE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75230.1.
    RefSeqiYP_222591.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75230; AAX75230; BruAb1_1921.
    GeneIDi3340541.
    KEGGibmb:BruAb1_1921.
    PATRICi17825671. VBIBruAbo15061_2028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75230.1 .
    RefSeqi YP_222591.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57AV4.
    SMRi Q57AV4. Positions 16-236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1921.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75230 ; AAX75230 ; BruAb1_1921 .
    GeneIDi 3340541.
    KEGGi bmb:BruAb1_1921.
    PATRICi 17825671. VBIBruAbo15061_2028.

    Phylogenomic databases

    eggNOGi COG0653.
    HOGENOMi HOG000218168.
    KOi K03070.
    OMAi MPPKTYA.
    OrthoDBi EOG654P48.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-1968-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPi MF_01382. SecA.
    InterProi IPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view ]
    Pfami PF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view ]
    PRINTSi PR00906. SECA.
    SMARTi SM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsi TIGR00963. secA. 1 hit.
    PROSITEi PS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiSECA_BRUAB
    AccessioniPrimary (citable) accession number: Q57AV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3