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Q57AM8

- AROK_BRUAB

UniProt

Q57AM8 - AROK_BRUAB

Protein

Shikimate kinase

Gene

aroK

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

    Catalytic activityi

    ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi37 – 371MagnesiumUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei101 – 1011Substrate; via amide nitrogenUniRule annotation
    Binding sitei139 – 1391ATPUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 386ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. shikimate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2053-MONOMER.
    UniPathwayiUPA00053; UER00088.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
    Short name:
    SKUniRule annotation
    Gene namesi
    Name:aroKUniRule annotation
    Ordered Locus Names:BruAb1_2004
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Shikimate kinasePRO_0000237854Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_2004.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57AM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0703.
    HOGENOMiHOG000032568.
    KOiK00891.
    OMAiVWLKAEL.
    OrthoDBiEOG6SJJGD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00109. Shikimate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    [Graphical view]
    PfamiPF01202. SKI. 1 hit.
    [Graphical view]
    PRINTSiPR01100. SHIKIMTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57AM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTNKQTNL HRQTETIRQL LGSKVVVLVG LMGAGKSTIG RKVANMLNLP    50
    FKDADTEIET VSRMTVAELF EAYGEVEFRD LERRVILRLL DDGPMVLATG 100
    GGAYMNAETR AAIAEAGISI WINADLDVLM ERVSRRQNRP LLRNSDPRGV 150
    MQRLMDERYP VYALAELHLM TRDEKKEVIA AELIEVLAAH LEKEQAASAG 200
    Length:200
    Mass (Da):22,235
    Last modified:May 10, 2005 - v1
    Checksum:iF11D503663A80C62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75306.1.
    RefSeqiYP_222667.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75306; AAX75306; BruAb1_2004.
    GeneIDi3340580.
    KEGGibmb:BruAb1_2004.
    PATRICi17825853. VBIBruAbo15061_2115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75306.1 .
    RefSeqi YP_222667.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57AM8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_2004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75306 ; AAX75306 ; BruAb1_2004 .
    GeneIDi 3340580.
    KEGGi bmb:BruAb1_2004.
    PATRICi 17825853. VBIBruAbo15061_2115.

    Phylogenomic databases

    eggNOGi COG0703.
    HOGENOMi HOG000032568.
    KOi K00891.
    OMAi VWLKAEL.
    OrthoDBi EOG6SJJGD.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00088 .
    BioCyci BABO262698:GJC2-2053-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00109. Shikimate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    [Graphical view ]
    Pfami PF01202. SKI. 1 hit.
    [Graphical view ]
    PRINTSi PR01100. SHIKIMTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiAROK_BRUAB
    AccessioniPrimary (citable) accession number: Q57AM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3