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Q57AM8 (AROK_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Shikimate kinase

Short name=SK
EC=2.7.1.71
Gene names
Name:aroK
Ordered Locus Names:BruAb1_2004
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP-Rule MF_00109

Catalytic activity

ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP-Rule MF_00109

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00109

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP-Rule MF_00109

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00109

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00109.

Sequence similarities

Belongs to the shikimate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

shikimate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Shikimate kinase HAMAP-Rule MF_00109
PRO_0000237854

Regions

Nucleotide binding33 – 386ATP By similarity

Sites

Metal binding371Magnesium By similarity
Binding site551Substrate By similarity
Binding site791Substrate By similarity
Binding site1011Substrate; via amide nitrogen By similarity
Binding site1391ATP By similarity
Binding site1581Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57AM8 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: F11D503663A80C62

FASTA20022,235
        10         20         30         40         50         60 
MSGTNKQTNL HRQTETIRQL LGSKVVVLVG LMGAGKSTIG RKVANMLNLP FKDADTEIET 

        70         80         90        100        110        120 
VSRMTVAELF EAYGEVEFRD LERRVILRLL DDGPMVLATG GGAYMNAETR AAIAEAGISI 

       130        140        150        160        170        180 
WINADLDVLM ERVSRRQNRP LLRNSDPRGV MQRLMDERYP VYALAELHLM TRDEKKEVIA 

       190        200 
AELIEVLAAH LEKEQAASAG 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX75306.1.
RefSeqYP_222667.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57AM8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_2004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75306; AAX75306; BruAb1_2004.
GeneID3340580.
KEGGbmb:BruAb1_2004.
PATRIC17825853. VBIBruAbo15061_2115.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0703.
HOGENOMHOG000032568.
KOK00891.
OMAADIPWIF.
OrthoDBEOG6SJJGD.
ProtClustDBPRK13946.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2053-MONOMER.
UniPathwayUPA00053; UER00088.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00109. Shikimate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view]
PfamPF01202. SKI. 1 hit.
[Graphical view]
PRINTSPR01100. SHIKIMTKNASE.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROK_BRUAB
AccessionPrimary (citable) accession number: Q57AM8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names