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Q57AH5

- HIS5_BRUAB

UniProt

Q57AH5 - HIS5_BRUAB

Protein

Imidazole glycerol phosphate synthase subunit HisH

Gene

hisH

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.UniRule annotation

    Catalytic activityi

    5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881NucleophileUniRule annotation
    Active sitei196 – 1961UniRule annotation
    Active sitei198 – 1981UniRule annotation

    GO - Molecular functioni

    1. imidazoleglycerol-phosphate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-HAMAP
    2. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2108-MONOMER.
    UniPathwayiUPA00031; UER00010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Imidazole glycerol phosphate synthase subunit HisHUniRule annotation (EC:2.4.2.-UniRule annotation)
    Alternative name(s):
    IGP synthase glutamine amidotransferase subunitUniRule annotation
    IGP synthase subunit HisHUniRule annotation
    ImGP synthase subunit HisHUniRule annotation
    Short name:
    IGPS subunit HisHUniRule annotation
    Gene namesi
    Name:hisHUniRule annotation
    Ordered Locus Names:BruAb1_2058
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Imidazole glycerol phosphate synthase subunit HisHPRO_0000231707Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of HisH and HisF.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_2058.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57AH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 216215Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0118.
    HOGENOMiHOG000025030.
    KOiK02501.
    OMAiMGWNDLV.
    OrthoDBiEOG69KV05.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    HAMAPiMF_00278. HisH.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR010139. Imidazole-glycPsynth_HisH.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000495. Amidotransf_hisH. 1 hit.
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR01855. IMP_synth_hisH. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57AH5-1 [UniParc]FASTAAdd to Basket

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    MRVAIIDYGS GNLRSATKAF ERAAHESGIS AEIDLTCDAQ RVASADRIVL    50
    PGVGAYADCR RGLDAAPGMV EALNDTVLKK ARPFLGICVG MQLMSERGLE 100
    KTVTNGLGWI AGDVREMVPS DASLKIPQIG WNRIHVKHSH PIFDGIPTGD 150
    DGLHAYFVHS YMLDAKNASD VLAVTDYGGD VTAAVGRDNM VGTQFHPEKS 200
    QLLGLSLIAN FLKWKP 216
    Length:216
    Mass (Da):23,232
    Last modified:May 10, 2005 - v1
    Checksum:iE87CAEF18E2D1A09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75359.1.
    RefSeqiYP_222720.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75359; AAX75359; BruAb1_2058.
    GeneIDi3339689.
    KEGGibmb:BruAb1_2058.
    PATRICi17825969. VBIBruAbo15061_2172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75359.1 .
    RefSeqi YP_222720.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57AH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_2058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75359 ; AAX75359 ; BruAb1_2058 .
    GeneIDi 3339689.
    KEGGi bmb:BruAb1_2058.
    PATRICi 17825969. VBIBruAbo15061_2172.

    Phylogenomic databases

    eggNOGi COG0118.
    HOGENOMi HOG000025030.
    KOi K02501.
    OMAi MGWNDLV.
    OrthoDBi EOG69KV05.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00010 .
    BioCyci BABO262698:GJC2-2108-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    HAMAPi MF_00278. HisH.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR010139. Imidazole-glycPsynth_HisH.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000495. Amidotransf_hisH. 1 hit.
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR01855. IMP_synth_hisH. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiHIS5_BRUAB
    AccessioniPrimary (citable) accession number: Q57AH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3