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Q57AH2

- HIS2_BRUAB

UniProt

Q57AH2 - HIS2_BRUAB

Protein

Phosphoribosyl-ATP pyrophosphatase

Gene

hisE

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2111-MONOMER.
    UniPathwayiUPA00031; UER00007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
    Short name:
    PRA-PHUniRule annotation
    Gene namesi
    Name:hisEUniRule annotation
    Ordered Locus Names:BruAb1_2061
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107Phosphoribosyl-ATP pyrophosphatasePRO_0000230168Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_2061.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57AH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-PH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0140.
    HOGENOMiHOG000220965.
    KOiK01523.
    OMAiPEKCAEK.
    OrthoDBiEOG6CGCMH.

    Family and domain databases

    HAMAPiMF_01020. HisE.
    InterProiIPR008179. PRib-ATP_PPHydrolase.
    IPR021130. PRib-ATP_PPHydrolase-like.
    [Graphical view]
    PfamiPF01503. PRA-PH. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57AH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQFTLADLE RIVAERASVT DGTSYTASLV AKGQPKAAQK LGEEAVETVI    50
    AAVSGDRAGV VSESADLLYH LAVVWNIAGV ALEDVLQELQ RRTAQTGLAE 100
    KASRPKG 107
    Length:107
    Mass (Da):11,253
    Last modified:May 10, 2005 - v1
    Checksum:i4335A80E49ACB391
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75362.1.
    RefSeqiYP_222723.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75362; AAX75362; BruAb1_2061.
    GeneIDi3339692.
    KEGGibmb:BruAb1_2061.
    PATRICi17825975. VBIBruAbo15061_2175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75362.1 .
    RefSeqi YP_222723.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57AH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_2061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75362 ; AAX75362 ; BruAb1_2061 .
    GeneIDi 3339692.
    KEGGi bmb:BruAb1_2061.
    PATRICi 17825975. VBIBruAbo15061_2175.

    Phylogenomic databases

    eggNOGi COG0140.
    HOGENOMi HOG000220965.
    KOi K01523.
    OMAi PEKCAEK.
    OrthoDBi EOG6CGCMH.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00007 .
    BioCyci BABO262698:GJC2-2111-MONOMER.

    Family and domain databases

    HAMAPi MF_01020. HisE.
    InterProi IPR008179. PRib-ATP_PPHydrolase.
    IPR021130. PRib-ATP_PPHydrolase-like.
    [Graphical view ]
    Pfami PF01503. PRA-PH. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiHIS2_BRUAB
    AccessioniPrimary (citable) accession number: Q57AH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3