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Q57AH2

- HIS2_BRUAB

UniProt

Q57AH2 - HIS2_BRUAB

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Protein

Phosphoribosyl-ATP pyrophosphatase

Gene
hisE, BruAb1_2061
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2111-MONOMER.
UniPathwayiUPA00031; UER00007.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-ATP pyrophosphatase (EC:3.6.1.31)
Short name:
PRA-PH
Gene namesi
Name:hisE
Ordered Locus Names:BruAb1_2061
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Phosphoribosyl-ATP pyrophosphataseUniRule annotationPRO_0000230168Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb1_2061.

Structurei

3D structure databases

ProteinModelPortaliQ57AH2.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-PH family.

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000220965.
KOiK01523.
OMAiPEKCAEK.
OrthoDBiEOG6CGCMH.

Family and domain databases

HAMAPiMF_01020. HisE.
InterProiIPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]
PfamiPF01503. PRA-PH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57AH2-1 [UniParc]FASTAAdd to Basket

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MSQFTLADLE RIVAERASVT DGTSYTASLV AKGQPKAAQK LGEEAVETVI    50
AAVSGDRAGV VSESADLLYH LAVVWNIAGV ALEDVLQELQ RRTAQTGLAE 100
KASRPKG 107
Length:107
Mass (Da):11,253
Last modified:May 10, 2005 - v1
Checksum:i4335A80E49ACB391
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75362.1.
RefSeqiYP_222723.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75362; AAX75362; BruAb1_2061.
GeneIDi3339692.
KEGGibmb:BruAb1_2061.
PATRICi17825975. VBIBruAbo15061_2175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75362.1 .
RefSeqi YP_222723.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57AH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_2061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75362 ; AAX75362 ; BruAb1_2061 .
GeneIDi 3339692.
KEGGi bmb:BruAb1_2061.
PATRICi 17825975. VBIBruAbo15061_2175.

Phylogenomic databases

eggNOGi COG0140.
HOGENOMi HOG000220965.
KOi K01523.
OMAi PEKCAEK.
OrthoDBi EOG6CGCMH.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00007 .
BioCyci BABO262698:GJC2-2111-MONOMER.

Family and domain databases

HAMAPi MF_01020. HisE.
InterProi IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view ]
Pfami PF01503. PRA-PH. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiHIS2_BRUAB
AccessioniPrimary (citable) accession number: Q57AH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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