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Q57AF0

- TRPB_BRUAB

UniProt

Q57AF0 - TRPB_BRUAB

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Protein
Tryptophan synthase beta chain
Gene
trpB, BruAb1_2085
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2135-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain (EC:4.2.1.20)
Gene namesi
Name:trpB
Ordered Locus Names:BruAb1_2085
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Tryptophan synthase beta chainUniRule annotation
PRO_1000018330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ57AF0.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains By similarity.

Protein-protein interaction databases

STRINGi262698.BruAb1_2085.

Structurei

3D structure databases

ProteinModelPortaliQ57AF0.
SMRiQ57AF0. Positions 20-401.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.

Phylogenomic databases

eggNOGiCOG0133.
HOGENOMiHOG000161710.
KOiK01696.
OMAiAPKLTKG.
OrthoDBiEOG6GFGH7.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57AF0-1 [UniParc]FASTAAdd to Basket

« Hide

MNKPVAPNSY KTGPDEEGMF GIFGGRFVAE TLMPLILELQ QAYETARNDP    50
EFKAELNALS TFYAGRPSKL YYAEGLSKHL GGAKIYFKRE DLNHTGSHKI 100
NNCLGQILLA KRMGKTRIIA ETGAGQHGVA SATVAARFGL PCIVYVGATD 150
VERQKPNVFR MKLLGAEVKP VSAGNGTLKD AMNEALRDWV TNVEDTYYLI 200
GTAAGPHPYP ELVRDFQSVI GTEARQQILE QEGRLPDVIV AAVGGGSNAI 250
GLFHPFLDDA SVKIVGVEAG GRGLEGEEHC ASMSAGRPGV LHGNRTYLLQ 300
NADGQILEGH SVSAGLDYPG VGPEHSWLKD SGRVDYVPIL DNEALDAFQL 350
CTRTEGIIPA LESAHAIAQA VKMAPTMGKD KVMIVNLSGR GDKDVHTVGK 400
LLGMDI 406
Length:406
Mass (Da):43,567
Last modified:May 10, 2005 - v1
Checksum:iCBF39C5E6A8CA037
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75384.1.
RefSeqiYP_222745.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75384; AAX75384; BruAb1_2085.
GeneIDi3340524.
KEGGibmb:BruAb1_2085.
PATRICi17826025. VBIBruAbo15061_2200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX75384.1 .
RefSeqi YP_222745.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57AF0.
SMRi Q57AF0. Positions 20-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_2085.

Proteomic databases

PRIDEi Q57AF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75384 ; AAX75384 ; BruAb1_2085 .
GeneIDi 3340524.
KEGGi bmb:BruAb1_2085.
PATRICi 17826025. VBIBruAbo15061_2200.

Phylogenomic databases

eggNOGi COG0133.
HOGENOMi HOG000161710.
KOi K01696.
OMAi APKLTKG.
OrthoDBi EOG6GFGH7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .
BioCyci BABO262698:GJC2-2135-MONOMER.

Miscellaneous databases

PROi Q57AF0.

Family and domain databases

HAMAPi MF_00133. Trp_synth_beta.
InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view ]
PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00263. trpB. 1 hit.
PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiTRPB_BRUAB
AccessioniPrimary (citable) accession number: Q57AF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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