Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q57AF0 (TRPB_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase beta chain
EC=4.2.1.20
Gene names
Name:trpB
Ordered Locus Names:BruAb1_2085
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity. HAMAP-Rule MF_00133

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00133

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00133

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00133

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Tryptophan synthase beta chain HAMAP-Rule MF_00133
PRO_1000018330

Amino acid modifications

Modified residue991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57AF0 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: CBF39C5E6A8CA037

FASTA40643,567
        10         20         30         40         50         60 
MNKPVAPNSY KTGPDEEGMF GIFGGRFVAE TLMPLILELQ QAYETARNDP EFKAELNALS 

        70         80         90        100        110        120 
TFYAGRPSKL YYAEGLSKHL GGAKIYFKRE DLNHTGSHKI NNCLGQILLA KRMGKTRIIA 

       130        140        150        160        170        180 
ETGAGQHGVA SATVAARFGL PCIVYVGATD VERQKPNVFR MKLLGAEVKP VSAGNGTLKD 

       190        200        210        220        230        240 
AMNEALRDWV TNVEDTYYLI GTAAGPHPYP ELVRDFQSVI GTEARQQILE QEGRLPDVIV 

       250        260        270        280        290        300 
AAVGGGSNAI GLFHPFLDDA SVKIVGVEAG GRGLEGEEHC ASMSAGRPGV LHGNRTYLLQ 

       310        320        330        340        350        360 
NADGQILEGH SVSAGLDYPG VGPEHSWLKD SGRVDYVPIL DNEALDAFQL CTRTEGIIPA 

       370        380        390        400 
LESAHAIAQA VKMAPTMGKD KVMIVNLSGR GDKDVHTVGK LLGMDI

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017223 Genomic DNA. Translation: AAX75384.1.
RefSeqYP_222745.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57AF0.
SMRQ57AF0. Positions 20-401.
ModBaseSearch...

Protein-protein interaction databases

STRING262698.BruAb1_2085.

Proteomic databases

PRIDEQ57AF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75384; AAX75384; BruAb1_2085.
GeneID3340524.
KEGGbmb:BruAb1_2085.
PATRIC17826025. VBIBruAbo15061_2200.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0133.
HOGENOMHOG000161710.
KOK01696.
OMAREDLCHT.
ProtClustDBPRK04346.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2135-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

HAMAPMF_00133. Trp_synth_beta.
InterProIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMSSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMsTIGR00263. trpB. 1 hit.
PROSITEPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPB_BRUAB
AccessionPrimary (citable) accession number: Q57AF0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents