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Q57AA4

- TRMB_BRUAB

UniProt

Q57AA4 - TRMB_BRUAB

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641S-adenosyl-L-methionineUniRule annotation
    Binding sitei89 – 891S-adenosyl-L-methionineUniRule annotation
    Binding sitei116 – 1161S-adenosyl-L-methionineUniRule annotation
    Active sitei138 – 1381By similarity
    Binding sitei138 – 1381S-adenosyl-L-methionineUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2184-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:BruAb1_2134
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferasePRO_0000229155Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_2134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57AA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 2154Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiYLTFIKK.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57AA4-1 [UniParc]FASTAAdd to Basket

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    MIDENHPMRA AGNFFGRRHG KPLRPHQSNL FEDLLPRLKL DLATPAPQDL    50
    RSLFEAPVET VRMEIGFGGG EHLHHESGRY PQSGFIGVEP FINGMAKMLA 100
    ALDQAPRPNL RLYDEDATAV LDWLPDASLA GIDLFYPDPW HKRRHWKRRF 150
    VSDANLDRFA RVLKPGAKFR FASDIEHYVN WTLQHCRRHA AFDWQAESPA 200
    DWNDAYEGWP GTRYEAKAFH EGRRAAYLTF IRR 233
    Length:233
    Mass (Da):26,986
    Last modified:May 10, 2005 - v1
    Checksum:i9CB9E04117775DCF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75430.1.
    RefSeqiYP_222791.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75430; AAX75430; BruAb1_2134.
    GeneIDi3340634.
    KEGGibmb:BruAb1_2134.
    PATRICi17826133. VBIBruAbo15061_2254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75430.1 .
    RefSeqi YP_222791.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57AA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_2134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75430 ; AAX75430 ; BruAb1_2134 .
    GeneIDi 3340634.
    KEGGi bmb:BruAb1_2134.
    PATRICi 17826133. VBIBruAbo15061_2254.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi YLTFIKK.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BABO262698:GJC2-2184-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiTRMB_BRUAB
    AccessioniPrimary (citable) accession number: Q57AA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3