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Q57A93 (FABA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

EC=4.2.1.59
Alternative name(s):
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
Beta-hydroxydecanoyl thioester dehydrase
Trans-2-decenoyl-[acyl-carrier-protein] isomerase
EC=5.3.3.14
Gene names
Name:fabA
Ordered Locus Names:BruAb1_2146
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length By similarity. HAMAP-Rule MF_00405

Catalytic activity

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00405

(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O. HAMAP-Rule MF_00405

Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein]. HAMAP-Rule MF_00405

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_00405

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00405

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00405.

Sequence similarities

Belongs to the thioester dehydratase family. FabA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1721723-hydroxydecanoyl-[acyl-carrier-protein] dehydratase HAMAP-Rule MF_00405
PRO_0000267723

Sites

Active site711 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57A93 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 492701CC908DB72A

FASTA17219,086
        10         20         30         40         50         60 
MAEQKSSYGY EELLACGRGE MFGPGNAQLP LPPMLMIHRI TEISETGGAF DKGYIRAEYD 

        70         80         90        100        110        120 
VRPDDWYFPC HFQGNPIMPG CLGLDGMWQL TGFFLGWLGE PGRGMALSTG EVKFKGMVRP 

       130        140        150        160        170 
HTKLLEYGID FKRVMRGRLV LGTADGWLKA DGELIYQATD LRVGLSKEGS AQ 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX75441.1.
RefSeqYP_222802.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57A93.
SMRQ57A93. Positions 3-171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_2146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75441; AAX75441; BruAb1_2146.
GeneID3340646.
KEGGbmb:BruAb1_2146.
PATRIC17826159. VBIBruAbo15061_2267.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0764.
HOGENOMHOG000277828.
KOK01716.
OMAQTRRLTM.
OrthoDBEOG6VB6SH.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2196-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.10.129.10. 1 hit.
HAMAPMF_00405. FabA.
InterProIPR010083. FabA.
IPR013114. FabA_FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMSSF54637. SSF54637. 1 hit.
TIGRFAMsTIGR01749. fabA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABA_BRUAB
AccessionPrimary (citable) accession number: Q57A93
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names