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Q57A93

- FABA_BRUAB

UniProt

Q57A93 - FABA_BRUAB

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Protein

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene

fabA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O.UniRule annotation
Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711UniRule annotation

GO - Molecular functioni

  1. 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-HAMAP
  2. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
  3. trans-2-decenoyl-acyl-carrier-protein isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2196-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxydecanoyl-[acyl-carrier-protein] dehydrataseUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabAUniRule annotation
Beta-hydroxydecanoyl thioester dehydraseUniRule annotation
Trans-2-decenoyl-[acyl-carrier-protein] isomeraseUniRule annotation (EC:5.3.3.14UniRule annotation)
Gene namesi
Name:fabAUniRule annotation
Ordered Locus Names:BruAb1_2146
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1721723-hydroxydecanoyl-[acyl-carrier-protein] dehydratasePRO_0000267723Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_2146.

Structurei

3D structure databases

ProteinModelPortaliQ57A93.
SMRiQ57A93. Positions 3-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0764.
HOGENOMiHOG000277828.
KOiK01716.
OMAiQTRRLTM.
OrthoDBiEOG6VB6SH.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00405. FabA.
InterProiIPR010083. FabA.
IPR013114. FabA_FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01749. fabA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57A93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEQKSSYGY EELLACGRGE MFGPGNAQLP LPPMLMIHRI TEISETGGAF
60 70 80 90 100
DKGYIRAEYD VRPDDWYFPC HFQGNPIMPG CLGLDGMWQL TGFFLGWLGE
110 120 130 140 150
PGRGMALSTG EVKFKGMVRP HTKLLEYGID FKRVMRGRLV LGTADGWLKA
160 170
DGELIYQATD LRVGLSKEGS AQ
Length:172
Mass (Da):19,086
Last modified:May 10, 2005 - v1
Checksum:i492701CC908DB72A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75441.1.
RefSeqiYP_222802.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75441; AAX75441; BruAb1_2146.
GeneIDi3340646.
KEGGibmb:BruAb1_2146.
PATRICi17826159. VBIBruAbo15061_2267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75441.1 .
RefSeqi YP_222802.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57A93.
SMRi Q57A93. Positions 3-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_2146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75441 ; AAX75441 ; BruAb1_2146 .
GeneIDi 3340646.
KEGGi bmb:BruAb1_2146.
PATRICi 17826159. VBIBruAbo15061_2267.

Phylogenomic databases

eggNOGi COG0764.
HOGENOMi HOG000277828.
KOi K01716.
OMAi QTRRLTM.
OrthoDBi EOG6VB6SH.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci BABO262698:GJC2-2196-MONOMER.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
HAMAPi MF_00405. FabA.
InterProi IPR010083. FabA.
IPR013114. FabA_FabZ.
IPR029069. HotDog_dom.
[Graphical view ]
Pfami PF07977. FabA. 1 hit.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
TIGRFAMsi TIGR01749. fabA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiFABA_BRUAB
AccessioniPrimary (citable) accession number: Q57A93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3