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Q57A93

- FABA_BRUAB

UniProt

Q57A93 - FABA_BRUAB

Protein

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene

fabA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.UniRule annotation

    Catalytic activityi

    A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation
    (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O.UniRule annotation
    Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711UniRule annotation

    GO - Molecular functioni

    1. 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-HAMAP
    2. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
    3. trans-2-decenoyl-acyl-carrier-protein isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, Lyase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2196-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxydecanoyl-[acyl-carrier-protein] dehydrataseUniRule annotation (EC:4.2.1.59UniRule annotation)
    Alternative name(s):
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabAUniRule annotation
    Beta-hydroxydecanoyl thioester dehydraseUniRule annotation
    Trans-2-decenoyl-[acyl-carrier-protein] isomeraseUniRule annotation (EC:5.3.3.14UniRule annotation)
    Gene namesi
    Name:fabAUniRule annotation
    Ordered Locus Names:BruAb1_2146
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1721723-hydroxydecanoyl-[acyl-carrier-protein] dehydratasePRO_0000267723Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_2146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57A93.
    SMRiQ57A93. Positions 3-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thioester dehydratase family. FabA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0764.
    HOGENOMiHOG000277828.
    KOiK01716.
    OMAiQTRRLTM.
    OrthoDBiEOG6VB6SH.

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    HAMAPiMF_00405. FabA.
    InterProiIPR010083. FabA.
    IPR013114. FabA_FabZ.
    IPR029069. HotDog_dom.
    [Graphical view]
    PfamiPF07977. FabA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.
    TIGRFAMsiTIGR01749. fabA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57A93-1 [UniParc]FASTAAdd to Basket

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    MAEQKSSYGY EELLACGRGE MFGPGNAQLP LPPMLMIHRI TEISETGGAF    50
    DKGYIRAEYD VRPDDWYFPC HFQGNPIMPG CLGLDGMWQL TGFFLGWLGE 100
    PGRGMALSTG EVKFKGMVRP HTKLLEYGID FKRVMRGRLV LGTADGWLKA 150
    DGELIYQATD LRVGLSKEGS AQ 172
    Length:172
    Mass (Da):19,086
    Last modified:May 10, 2005 - v1
    Checksum:i492701CC908DB72A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75441.1.
    RefSeqiYP_222802.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75441; AAX75441; BruAb1_2146.
    GeneIDi3340646.
    KEGGibmb:BruAb1_2146.
    PATRICi17826159. VBIBruAbo15061_2267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75441.1 .
    RefSeqi YP_222802.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57A93.
    SMRi Q57A93. Positions 3-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_2146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75441 ; AAX75441 ; BruAb1_2146 .
    GeneIDi 3340646.
    KEGGi bmb:BruAb1_2146.
    PATRICi 17826159. VBIBruAbo15061_2267.

    Phylogenomic databases

    eggNOGi COG0764.
    HOGENOMi HOG000277828.
    KOi K01716.
    OMAi QTRRLTM.
    OrthoDBi EOG6VB6SH.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci BABO262698:GJC2-2196-MONOMER.

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    HAMAPi MF_00405. FabA.
    InterProi IPR010083. FabA.
    IPR013114. FabA_FabZ.
    IPR029069. HotDog_dom.
    [Graphical view ]
    Pfami PF07977. FabA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    TIGRFAMsi TIGR01749. fabA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiFABA_BRUAB
    AccessioniPrimary (citable) accession number: Q57A93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3