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Protein

Protein MgtC

Gene

mgtC

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase (By similarity).By similarity

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MgtC
Gene namesi
Name:mgtC
Ordered Locus Names:BruAb2_0040
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Protein MgtCPRO_0000250523Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_0040.

Family & Domainsi

Sequence similaritiesi

Belongs to the MgtC/SapB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1285.
HOGENOMiHOG000080251.
KOiK07507.
OMAiEFTIAIN.
OrthoDBiEOG6H4KB4.

Family and domain databases

InterProiIPR003416. MgtCSapBSrpB_transpt.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.

Sequencei

Sequence statusi: Complete.

Q57A43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV
60 70 80 90 100
VFSSLVSGDS SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS
110 120 130 140 150
AAVGVLCGAG LISHAAVATV FIIAVNALLR PLVQVLEFQA MRRGAFQPTY
160 170 180 190 200
AIDIICHGDA EAQVRALLLR DIGDHLHIHE LESSNIEGTN RVEVSATVRA
210 220 230
DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL
Length:238
Mass (Da):25,357
Last modified:May 10, 2005 - v1
Checksum:i2D1E20FA7069CE60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75491.1.
RefSeqiYP_222852.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75491; AAX75491; BruAb2_0040.
GeneIDi3341895.
KEGGibmb:BruAb2_0040.
PATRICi17826271. VBIBruAbo15061_2322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75491.1.
RefSeqiYP_222852.1. NC_006933.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb2_0040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75491; AAX75491; BruAb2_0040.
GeneIDi3341895.
KEGGibmb:BruAb2_0040.
PATRICi17826271. VBIBruAbo15061_2322.

Phylogenomic databases

eggNOGiCOG1285.
HOGENOMiHOG000080251.
KOiK07507.
OMAiEFTIAIN.
OrthoDBiEOG6H4KB4.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2248-MONOMER.

Family and domain databases

InterProiIPR003416. MgtCSapBSrpB_transpt.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiMGTC_BRUAB
AccessioniPrimary (citable) accession number: Q57A43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.