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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2391-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:BruAb2_0182
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Histidine--tRNA ligasePRO_0000136123Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ579Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiVSYMLHT.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q579Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKADKMKA RLPRGFVDRV PDDLRAAEKM MATIREVYDL YGFEPVETPL
60 70 80 90 100
VEYTDALGKF LPDQDRPNEG VFSFQDDDEQ WLSLRYDLTA PLARYVAENF
110 120 130 140 150
ETLPKPYRSY RNGWVFRNEK PGPGRFRQFM QFDADTVGAP NVSADAEMCM
160 170 180 190 200
MMADTLERLG IQRGDYAIRV NNRKVLDGVL DAIGLEGEGN AAKRLNVLRA
210 220 230 240 250
IDKLDKFGPE GVRLLLGKGR LDESGDFTKG AQLPEAAIEK VLAFTAAGGA
260 270 280 290 300
DGAQTIANLQ AVVAGNAKGE EGVQELADMQ ALFFAGGYEG RVKIDPSVVR
310 320 330 340 350
GLEYYTGPVF EAELLFDVTN EDGQKVVFGS VGGGGRYDGL VSRFRGEPVP
360 370 380 390 400
ATGFSIGVSR LMTALKNLGK LDVSDTVGPV VVLVMDKDTQ NLGRYQKMVS
410 420 430 440 450
DLRKAGIRAE MYVGGSGMKA QMKYADRRAA PCVVIQGSQE REAGEVQIKD
460 470 480 490 500
LVEGKRLSAE IEDNVTWLES RPAQITVRED GLVDAVREIL DAQARDRAEQ

SK
Length:502
Mass (Da):55,136
Last modified:May 10, 2005 - v1
Checksum:i2A41BDC723CE687F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75626.1.
RefSeqiWP_002968826.1. NC_006933.1.
YP_222987.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75626; AAX75626; BruAb2_0182.
GeneIDi3827165.
KEGGibmb:BruAb2_0182.
PATRICi17826576. VBIBruAbo15061_2473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75626.1.
RefSeqiWP_002968826.1. NC_006933.1.
YP_222987.1. NC_006933.1.

3D structure databases

ProteinModelPortaliQ579Q8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75626; AAX75626; BruAb2_0182.
GeneIDi3827165.
KEGGibmb:BruAb2_0182.
PATRICi17826576. VBIBruAbo15061_2473.

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiVSYMLHT.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2391-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiSYH_BRUAB
AccessioniPrimary (citable) accession number: Q579Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 10, 2005
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.