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Q579Q8

- SYH_BRUAB

UniProt

Q579Q8 - SYH_BRUAB

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2391-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:BruAb2_0182
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Histidine--tRNA ligasePRO_0000136123Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb2_0182.

Structurei

3D structure databases

ProteinModelPortaliQ579Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiRGDYLIR.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q579Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKADKMKA RLPRGFVDRV PDDLRAAEKM MATIREVYDL YGFEPVETPL
60 70 80 90 100
VEYTDALGKF LPDQDRPNEG VFSFQDDDEQ WLSLRYDLTA PLARYVAENF
110 120 130 140 150
ETLPKPYRSY RNGWVFRNEK PGPGRFRQFM QFDADTVGAP NVSADAEMCM
160 170 180 190 200
MMADTLERLG IQRGDYAIRV NNRKVLDGVL DAIGLEGEGN AAKRLNVLRA
210 220 230 240 250
IDKLDKFGPE GVRLLLGKGR LDESGDFTKG AQLPEAAIEK VLAFTAAGGA
260 270 280 290 300
DGAQTIANLQ AVVAGNAKGE EGVQELADMQ ALFFAGGYEG RVKIDPSVVR
310 320 330 340 350
GLEYYTGPVF EAELLFDVTN EDGQKVVFGS VGGGGRYDGL VSRFRGEPVP
360 370 380 390 400
ATGFSIGVSR LMTALKNLGK LDVSDTVGPV VVLVMDKDTQ NLGRYQKMVS
410 420 430 440 450
DLRKAGIRAE MYVGGSGMKA QMKYADRRAA PCVVIQGSQE REAGEVQIKD
460 470 480 490 500
LVEGKRLSAE IEDNVTWLES RPAQITVRED GLVDAVREIL DAQARDRAEQ

SK
Length:502
Mass (Da):55,136
Last modified:May 10, 2005 - v1
Checksum:i2A41BDC723CE687F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017224 Genomic DNA. Translation: AAX75626.1.
RefSeqiYP_222987.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75626; AAX75626; BruAb2_0182.
GeneIDi3342136.
KEGGibmb:BruAb2_0182.
PATRICi17826576. VBIBruAbo15061_2473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017224 Genomic DNA. Translation: AAX75626.1 .
RefSeqi YP_222987.1. NC_006933.1.

3D structure databases

ProteinModelPortali Q579Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb2_0182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75626 ; AAX75626 ; BruAb2_0182 .
GeneIDi 3342136.
KEGGi bmb:BruAb2_0182.
PATRICi 17826576. VBIBruAbo15061_2473.

Phylogenomic databases

eggNOGi COG0124.
HOGENOMi HOG000018071.
KOi K01892.
OMAi RGDYLIR.
OrthoDBi EOG6BPDH4.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-2391-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiSYH_BRUAB
AccessioniPrimary (citable) accession number: Q579Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3