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Q579M7

- MUTL_BRUAB

UniProt

Q579M7 - MUTL_BRUAB

Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2423-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutLUniRule annotation
    Gene namesi
    Name:mutLUniRule annotation
    Ordered Locus Names:BruAb2_0214
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. mismatch repair complex Source: InterPro
    2. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623DNA mismatch repair protein MutLPRO_1000009998Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb2_0214.

    Structurei

    3D structure databases

    ProteinModelPortaliQ579M7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0323.
    HOGENOMiHOG000256550.
    KOiK03572.
    OMAiTEIVKRM.
    OrthoDBiEOG6P8TMH.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.565.10. 1 hit.
    HAMAPiMF_00149. DNA_mis_repair.
    InterProiIPR013507. DNA_mismatch_repair_C.
    IPR014762. DNA_mismatch_repair_CS.
    IPR002099. DNA_mismatch_repair_fam.
    IPR011186. DNA_mismatch_repair_MLH1/HexB.
    IPR020667. DNA_mismatch_repair_MutL.
    IPR003594. HATPase_ATP-bd.
    IPR014790. MutL_C.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
    PfamiPF01119. DNA_mis_repair. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF08676. MutL_C. 1 hit.
    [Graphical view]
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00853. MutL_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    TIGRFAMsiTIGR00585. mutl. 1 hit.
    PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q579M7-1 [UniParc]FASTAAdd to Basket

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    MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG    50
    KTLLRVTDNG SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI 100
    GSVSKLTLKS RPQDADSGFE VCVTGGHLDG PRPTALNRGT IVEVRDLFYA 150
    TPARLKFMKT DRAEATAITD VVKRIGIAFP HIRFSLAGTD RTPFEMPATG 200
    TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI PSFNRGNALH 250
    QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV 300
    HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG 350
    FGAQQSAPRP ANSYSPASWR TAPPAPRSEW SPQTAHPAHR PLDLQAAPAL 400
    RENGQAVLGD VAVPAADARA SVAEAPVELM QKPLGAARAQ IHENYIVAQT 450
    EDSLVIVDQH AAHERLVYEA LKNALHARPI AGQMLLIPEI VDLPEEDAQR 500
    LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL IRDLADEIAE 550
    HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT 600
    CNHGRPTYIE LKLTDIERLF GRR 623
    Length:623
    Mass (Da):66,783
    Last modified:May 10, 2005 - v1
    Checksum:i7CB97FEC4AE64BEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX75657.1.
    RefSeqiYP_223018.1. NC_006933.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75657; AAX75657; BruAb2_0214.
    GeneIDi3341625.
    KEGGibmb:BruAb2_0214.
    PATRICi17826637. VBIBruAbo15061_2503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX75657.1 .
    RefSeqi YP_223018.1. NC_006933.1.

    3D structure databases

    ProteinModelPortali Q579M7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb2_0214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75657 ; AAX75657 ; BruAb2_0214 .
    GeneIDi 3341625.
    KEGGi bmb:BruAb2_0214.
    PATRICi 17826637. VBIBruAbo15061_2503.

    Phylogenomic databases

    eggNOGi COG0323.
    HOGENOMi HOG000256550.
    KOi K03572.
    OMAi TEIVKRM.
    OrthoDBi EOG6P8TMH.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-2423-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.565.10. 1 hit.
    HAMAPi MF_00149. DNA_mis_repair.
    InterProi IPR013507. DNA_mismatch_repair_C.
    IPR014762. DNA_mismatch_repair_CS.
    IPR002099. DNA_mismatch_repair_fam.
    IPR011186. DNA_mismatch_repair_MLH1/HexB.
    IPR020667. DNA_mismatch_repair_MutL.
    IPR003594. HATPase_ATP-bd.
    IPR014790. MutL_C.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10073:SF12. PTHR10073:SF12. 1 hit.
    Pfami PF01119. DNA_mis_repair. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF08676. MutL_C. 1 hit.
    [Graphical view ]
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00853. MutL_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    TIGRFAMsi TIGR00585. mutl. 1 hit.
    PROSITEi PS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiMUTL_BRUAB
    AccessioniPrimary (citable) accession number: Q579M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3