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Q579F0

- HUTU_BRUAB

UniProt

Q579F0 - HUTU_BRUAB

Protein

Urocanate hydratase

Gene

hutU

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.UniRule annotation

    Cofactori

    Binds 1 NAD per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei410 – 4101UniRule annotation

    GO - Molecular functioni

    1. urocanate hydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
    2. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Histidine metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2510-MONOMER.
    UniPathwayiUPA00379; UER00550.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urocanate hydrataseUniRule annotation (EC:4.2.1.49UniRule annotation)
    Short name:
    UrocanaseUniRule annotation
    Alternative name(s):
    Imidazolonepropionate hydrolaseUniRule annotation
    Gene namesi
    Name:hutUUniRule annotation
    Ordered Locus Names:BruAb2_0301
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Urocanate hydratasePRO_1000025125Add
    BLAST

    Proteomic databases

    PRIDEiQ579F0.

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb2_0301.

    Structurei

    3D structure databases

    ProteinModelPortaliQ579F0.
    SMRiQ579F0. Positions 6-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urocanase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2987.
    HOGENOMiHOG000237606.
    KOiK01712.
    OMAiAVECRAS.
    OrthoDBiEOG62K1TR.

    Family and domain databases

    HAMAPiMF_00577. HutU.
    InterProiIPR023637. Urocanase.
    IPR023636. Urocanase_CS.
    [Graphical view]
    PfamiPF01175. Urocanase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001423. Urocanate_hydrat. 1 hit.
    SUPFAMiSSF111326. SSF111326. 1 hit.
    TIGRFAMsiTIGR01228. hutU. 1 hit.
    PROSITEiPS01233. UROCANASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q579F0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNPRHNERE VRSPRGDELN AKSWLTEAPL RMLMNNLDPD VAERPHELVV    50
    YGGIGRAART WDDFDRIVAT LKTLNDNETL LVQSGKPVGV FRTHKDAPRV 100
    LIANSNLVPH WANWDHFNEL DKKGLAMYGQ MTAGSWIYIG AQGIVQGTYE 150
    TFVEAGRQHY GGNLKGRWIL TGGLGGMGGA QPLAAVMAGA CCLAVECDET 200
    RADFRLRTRY VDEKTHSLDE ALAKIDAWTK AGEAKSIALI GNAAEIFPEL 250
    VKRGVKPDIV TDQTSAHDPV HGYLPLGWTV AEWRAKQEND PKAVEKAARA 300
    SMKVQVQAML DFWNAGIPTV DYGNNIRQMA LEEGLENAFA FPGFVPAYIR 350
    PLFCRGIGPY RWAALSGDPE DIAKTDAKVK ELLPDNKHLH NWLDMAKERI 400
    AFQGLPARIC WVGLGDRHRL GLAFNEMVRN GELKAPIVIG RDHLDSGSVA 450
    SPNRETEAMK DGSDAVSDWP LLNALLNTAS GATWVSLHHG GGVGMGFSQH 500
    AGMVICCDGT EDADRRLERV LWNDPATGVM RHADAGYDIA LDWARKQGLR 550
    LPAILGN 557
    Length:557
    Mass (Da):61,229
    Last modified:May 10, 2005 - v1
    Checksum:i98DC4B1A168ACAB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX75734.1.
    RefSeqiYP_223095.1. NC_006933.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75734; AAX75734; BruAb2_0301.
    GeneIDi3341973.
    KEGGibmb:BruAb2_0301.
    PATRICi17826838. VBIBruAbo15061_2602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX75734.1 .
    RefSeqi YP_223095.1. NC_006933.1.

    3D structure databases

    ProteinModelPortali Q579F0.
    SMRi Q579F0. Positions 6-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb2_0301.

    Proteomic databases

    PRIDEi Q579F0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75734 ; AAX75734 ; BruAb2_0301 .
    GeneIDi 3341973.
    KEGGi bmb:BruAb2_0301.
    PATRICi 17826838. VBIBruAbo15061_2602.

    Phylogenomic databases

    eggNOGi COG2987.
    HOGENOMi HOG000237606.
    KOi K01712.
    OMAi AVECRAS.
    OrthoDBi EOG62K1TR.

    Enzyme and pathway databases

    UniPathwayi UPA00379 ; UER00550 .
    BioCyci BABO262698:GJC2-2510-MONOMER.

    Family and domain databases

    HAMAPi MF_00577. HutU.
    InterProi IPR023637. Urocanase.
    IPR023636. Urocanase_CS.
    [Graphical view ]
    Pfami PF01175. Urocanase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001423. Urocanate_hydrat. 1 hit.
    SUPFAMi SSF111326. SSF111326. 1 hit.
    TIGRFAMsi TIGR01228. hutU. 1 hit.
    PROSITEi PS01233. UROCANASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiHUTU_BRUAB
    AccessioniPrimary (citable) accession number: Q579F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3