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Q579F0 (HUTU_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urocanate hydratase
Short name=Urocanase
EC=4.2.1.49
Alternative name(s):
Imidazolonepropionate hydrolase
Gene names
Name:hutU
Ordered Locus Names:BruAb2_0301
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O. HAMAP-Rule MF_00577

Cofactor

Binds 1 NAD per subunit By similarity.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3. HAMAP-Rule MF_00577

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the urocanase family.

Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: UniProtKB-UniPathway

histidine catabolic process to glutamate and formate

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionurocanate hydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Urocanate hydratase HAMAP-Rule MF_00577
PRO_1000025125

Sites

Active site4101 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q579F0 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 98DC4B1A168ACAB4

FASTA55761,229
        10         20         30         40         50         60 
MSNPRHNERE VRSPRGDELN AKSWLTEAPL RMLMNNLDPD VAERPHELVV YGGIGRAART 

        70         80         90        100        110        120 
WDDFDRIVAT LKTLNDNETL LVQSGKPVGV FRTHKDAPRV LIANSNLVPH WANWDHFNEL 

       130        140        150        160        170        180 
DKKGLAMYGQ MTAGSWIYIG AQGIVQGTYE TFVEAGRQHY GGNLKGRWIL TGGLGGMGGA 

       190        200        210        220        230        240 
QPLAAVMAGA CCLAVECDET RADFRLRTRY VDEKTHSLDE ALAKIDAWTK AGEAKSIALI 

       250        260        270        280        290        300 
GNAAEIFPEL VKRGVKPDIV TDQTSAHDPV HGYLPLGWTV AEWRAKQEND PKAVEKAARA 

       310        320        330        340        350        360 
SMKVQVQAML DFWNAGIPTV DYGNNIRQMA LEEGLENAFA FPGFVPAYIR PLFCRGIGPY 

       370        380        390        400        410        420 
RWAALSGDPE DIAKTDAKVK ELLPDNKHLH NWLDMAKERI AFQGLPARIC WVGLGDRHRL 

       430        440        450        460        470        480 
GLAFNEMVRN GELKAPIVIG RDHLDSGSVA SPNRETEAMK DGSDAVSDWP LLNALLNTAS 

       490        500        510        520        530        540 
GATWVSLHHG GGVGMGFSQH AGMVICCDGT EDADRRLERV LWNDPATGVM RHADAGYDIA 

       550 
LDWARKQGLR LPAILGN

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017224 Genomic DNA. Translation: AAX75734.1.
RefSeqYP_223095.1. NC_006933.1.

3D structure databases

HSSPHSSP built from PDB template 1UWK based on UniProtKB P25080.
ProteinModelPortalQ579F0.
SMRQ579F0. Positions 6-552.
ModBaseSearch...

Protein-protein interaction databases

STRING262698.BruAb2_0301.

Proteomic databases

PRIDEQ579F0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75734; AAX75734; BruAb2_0301.
GeneID3341973.
KEGGbmb:BruAb2_0301.
PATRIC17826838. VBIBruAbo15061_2602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2987.
HOGENOMHOG000237606.
KOK01712.
OMAIRQMAFE.
ProtClustDBPRK05414.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2510-MONOMER.
UniPathwayUPA00379; UER00550.

Family and domain databases

HAMAPMF_00577. HutU.
InterProIPR000193. Urocanase.
IPR023636. Urocanase_CS.
IPR023637. Urocanase_dom.
[Graphical view]
PANTHERPTHR32312. PTHR32312. 1 hit.
PfamPF01175. Urocanase. 1 hit.
[Graphical view]
PIRSFPIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMSSF111326. Urocanase. 1 hit.
TIGRFAMsTIGR01228. hutU. 1 hit.
PROSITEPS01233. UROCANASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHUTU_BRUAB
AccessionPrimary (citable) accession number: Q579F0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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