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Q579F0

- HUTU_BRUAB

UniProt

Q579F0 - HUTU_BRUAB

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Protein

Urocanate hydratase

Gene

hutU

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.UniRule annotation

Cofactori

Binds 1 NAD per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101UniRule annotation

GO - Molecular functioni

  1. urocanate hydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
  2. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Histidine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2510-MONOMER.
UniPathwayiUPA00379; UER00550.

Names & Taxonomyi

Protein namesi
Recommended name:
Urocanate hydrataseUniRule annotation (EC:4.2.1.49UniRule annotation)
Short name:
UrocanaseUniRule annotation
Alternative name(s):
Imidazolonepropionate hydrolaseUniRule annotation
Gene namesi
Name:hutUUniRule annotation
Ordered Locus Names:BruAb2_0301
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Urocanate hydratasePRO_1000025125Add
BLAST

Proteomic databases

PRIDEiQ579F0.

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_0301.

Structurei

3D structure databases

ProteinModelPortaliQ579F0.
SMRiQ579F0. Positions 6-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urocanase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2987.
HOGENOMiHOG000237606.
KOiK01712.
OMAiAVECRAS.
OrthoDBiEOG62K1TR.

Family and domain databases

HAMAPiMF_00577. HutU.
InterProiIPR023637. Urocanase.
IPR023636. Urocanase_CS.
[Graphical view]
PfamiPF01175. Urocanase. 1 hit.
[Graphical view]
PIRSFiPIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMiSSF111326. SSF111326. 1 hit.
TIGRFAMsiTIGR01228. hutU. 1 hit.
PROSITEiPS01233. UROCANASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q579F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNPRHNERE VRSPRGDELN AKSWLTEAPL RMLMNNLDPD VAERPHELVV
60 70 80 90 100
YGGIGRAART WDDFDRIVAT LKTLNDNETL LVQSGKPVGV FRTHKDAPRV
110 120 130 140 150
LIANSNLVPH WANWDHFNEL DKKGLAMYGQ MTAGSWIYIG AQGIVQGTYE
160 170 180 190 200
TFVEAGRQHY GGNLKGRWIL TGGLGGMGGA QPLAAVMAGA CCLAVECDET
210 220 230 240 250
RADFRLRTRY VDEKTHSLDE ALAKIDAWTK AGEAKSIALI GNAAEIFPEL
260 270 280 290 300
VKRGVKPDIV TDQTSAHDPV HGYLPLGWTV AEWRAKQEND PKAVEKAARA
310 320 330 340 350
SMKVQVQAML DFWNAGIPTV DYGNNIRQMA LEEGLENAFA FPGFVPAYIR
360 370 380 390 400
PLFCRGIGPY RWAALSGDPE DIAKTDAKVK ELLPDNKHLH NWLDMAKERI
410 420 430 440 450
AFQGLPARIC WVGLGDRHRL GLAFNEMVRN GELKAPIVIG RDHLDSGSVA
460 470 480 490 500
SPNRETEAMK DGSDAVSDWP LLNALLNTAS GATWVSLHHG GGVGMGFSQH
510 520 530 540 550
AGMVICCDGT EDADRRLERV LWNDPATGVM RHADAGYDIA LDWARKQGLR

LPAILGN
Length:557
Mass (Da):61,229
Last modified:May 10, 2005 - v1
Checksum:i98DC4B1A168ACAB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017224 Genomic DNA. Translation: AAX75734.1.
RefSeqiYP_223095.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75734; AAX75734; BruAb2_0301.
GeneIDi3341973.
KEGGibmb:BruAb2_0301.
PATRICi17826838. VBIBruAbo15061_2602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017224 Genomic DNA. Translation: AAX75734.1 .
RefSeqi YP_223095.1. NC_006933.1.

3D structure databases

ProteinModelPortali Q579F0.
SMRi Q579F0. Positions 6-552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb2_0301.

Proteomic databases

PRIDEi Q579F0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75734 ; AAX75734 ; BruAb2_0301 .
GeneIDi 3341973.
KEGGi bmb:BruAb2_0301.
PATRICi 17826838. VBIBruAbo15061_2602.

Phylogenomic databases

eggNOGi COG2987.
HOGENOMi HOG000237606.
KOi K01712.
OMAi AVECRAS.
OrthoDBi EOG62K1TR.

Enzyme and pathway databases

UniPathwayi UPA00379 ; UER00550 .
BioCyci BABO262698:GJC2-2510-MONOMER.

Family and domain databases

HAMAPi MF_00577. HutU.
InterProi IPR023637. Urocanase.
IPR023636. Urocanase_CS.
[Graphical view ]
Pfami PF01175. Urocanase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMi SSF111326. SSF111326. 1 hit.
TIGRFAMsi TIGR01228. hutU. 1 hit.
PROSITEi PS01233. UROCANASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiHUTU_BRUAB
AccessioniPrimary (citable) accession number: Q579F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3