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Q579E7

- HUTI_BRUAB

UniProt

Q579E7 - HUTI_BRUAB

Protein

Imidazolonepropionase

Gene

hutI

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

    Cofactori

    Binds 1 zinc or iron ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi73 – 731Zinc or ironUniRule annotation
    Metal bindingi75 – 751Zinc or ironUniRule annotation
    Binding sitei82 – 821SubstrateUniRule annotation
    Binding sitei95 – 951SubstrateUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Binding sitei178 – 1781SubstrateUniRule annotation
    Metal bindingi243 – 2431Zinc or ironUniRule annotation
    Binding sitei246 – 2461SubstrateUniRule annotation
    Metal bindingi318 – 3181Zinc or ironUniRule annotation

    GO - Molecular functioni

    1. imidazolonepropionase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
    2. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Histidine metabolism

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2513-MONOMER.
    UniPathwayiUPA00379; UER00551.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
    Alternative name(s):
    Imidazolone-5-propionate hydrolaseUniRule annotation
    Gene namesi
    Name:hutIUniRule annotation
    Ordered Locus Names:BruAb2_0304
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405ImidazolonepropionasePRO_0000306443Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb2_0304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ579E7.
    SMRiQ579E7. Positions 5-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HutI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1228.
    HOGENOMiHOG000218461.
    KOiK01468.
    OMAiICAEMLP.
    OrthoDBiEOG63C0XD.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_00372. HutI.
    InterProiIPR005920. HutI.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR01224. hutI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q579E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKNSSTVFT HARIATLEEK AANLGLIEEA ALVVKDARIV YAGPENKLPD    50
    EYASFEKIDC GNRLITPGLI DCHTHLVHAG NRAHEFELRL QGATYEEVAR 100
    AGGGIVSSVR NLRAASEDDL VRETLPRLDA LIAEGVTTVE VKSGYGLDRD 150
    SEIKSLKAAR RLGEERDVAI RTTFLGAHAL PPEMNGDKAA YIDRVINDML 200
    PAIAEQGLAD AVDGFCEGIA FLPDEIARVF DAAKAHDIPV KLHADQLSNL 250
    HGAALAASYG ALSADHLEYT DADGAAAMAS AGTVAVLLPG AYYFIRETQK 300
    PPVEAFRAAG TKMALATDNN PGTSPLTSLL LTMNMGATLF RMTVEECIAG 350
    VTREAARALG ILDQTGTLEI GKDADLAIWD IERPAELVYR IGFNPLWKRV 400
    FKGQI 405
    Length:405
    Mass (Da):43,520
    Last modified:May 10, 2005 - v1
    Checksum:iA55470DFB24E994E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX75737.1.
    RefSeqiYP_223098.1. NC_006933.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75737; AAX75737; BruAb2_0304.
    GeneIDi3341633.
    KEGGibmb:BruAb2_0304.
    PATRICi17826844. VBIBruAbo15061_2605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX75737.1 .
    RefSeqi YP_223098.1. NC_006933.1.

    3D structure databases

    ProteinModelPortali Q579E7.
    SMRi Q579E7. Positions 5-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb2_0304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75737 ; AAX75737 ; BruAb2_0304 .
    GeneIDi 3341633.
    KEGGi bmb:BruAb2_0304.
    PATRICi 17826844. VBIBruAbo15061_2605.

    Phylogenomic databases

    eggNOGi COG1228.
    HOGENOMi HOG000218461.
    KOi K01468.
    OMAi ICAEMLP.
    OrthoDBi EOG63C0XD.

    Enzyme and pathway databases

    UniPathwayi UPA00379 ; UER00551 .
    BioCyci BABO262698:GJC2-2513-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_00372. HutI.
    InterProi IPR005920. HutI.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR01224. hutI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiHUTI_BRUAB
    AccessioniPrimary (citable) accession number: Q579E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3