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Q579E7

- HUTI_BRUAB

UniProt

Q579E7 - HUTI_BRUAB

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Protein

Imidazolonepropionase

Gene

hutI

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

Cofactori

Zn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 1 zinc or iron ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Zinc or ironUniRule annotation
Metal bindingi75 – 751Zinc or ironUniRule annotation
Binding sitei82 – 821SubstrateUniRule annotation
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Metal bindingi243 – 2431Zinc or ironUniRule annotation
Binding sitei246 – 2461SubstrateUniRule annotation
Metal bindingi318 – 3181Zinc or ironUniRule annotation

GO - Molecular functioni

  1. imidazolonepropionase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
  2. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Histidine metabolism

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2513-MONOMER.
UniPathwayiUPA00379; UER00551.

Names & Taxonomyi

Protein namesi
Recommended name:
ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
Alternative name(s):
Imidazolone-5-propionate hydrolaseUniRule annotation
Gene namesi
Name:hutIUniRule annotation
Ordered Locus Names:BruAb2_0304
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405ImidazolonepropionasePRO_0000306443Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_0304.

Structurei

3D structure databases

ProteinModelPortaliQ579E7.
SMRiQ579E7. Positions 5-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HutI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1228.
HOGENOMiHOG000218461.
KOiK01468.
OMAiICAEMLP.
OrthoDBiEOG63C0XD.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_00372. HutI.
InterProiIPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR01224. hutI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q579E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKNSSTVFT HARIATLEEK AANLGLIEEA ALVVKDARIV YAGPENKLPD
60 70 80 90 100
EYASFEKIDC GNRLITPGLI DCHTHLVHAG NRAHEFELRL QGATYEEVAR
110 120 130 140 150
AGGGIVSSVR NLRAASEDDL VRETLPRLDA LIAEGVTTVE VKSGYGLDRD
160 170 180 190 200
SEIKSLKAAR RLGEERDVAI RTTFLGAHAL PPEMNGDKAA YIDRVINDML
210 220 230 240 250
PAIAEQGLAD AVDGFCEGIA FLPDEIARVF DAAKAHDIPV KLHADQLSNL
260 270 280 290 300
HGAALAASYG ALSADHLEYT DADGAAAMAS AGTVAVLLPG AYYFIRETQK
310 320 330 340 350
PPVEAFRAAG TKMALATDNN PGTSPLTSLL LTMNMGATLF RMTVEECIAG
360 370 380 390 400
VTREAARALG ILDQTGTLEI GKDADLAIWD IERPAELVYR IGFNPLWKRV

FKGQI
Length:405
Mass (Da):43,520
Last modified:May 10, 2005 - v1
Checksum:iA55470DFB24E994E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75737.1.
RefSeqiYP_223098.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75737; AAX75737; BruAb2_0304.
GeneIDi3341633.
KEGGibmb:BruAb2_0304.
PATRICi17826844. VBIBruAbo15061_2605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75737.1 .
RefSeqi YP_223098.1. NC_006933.1.

3D structure databases

ProteinModelPortali Q579E7.
SMRi Q579E7. Positions 5-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb2_0304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75737 ; AAX75737 ; BruAb2_0304 .
GeneIDi 3341633.
KEGGi bmb:BruAb2_0304.
PATRICi 17826844. VBIBruAbo15061_2605.

Phylogenomic databases

eggNOGi COG1228.
HOGENOMi HOG000218461.
KOi K01468.
OMAi ICAEMLP.
OrthoDBi EOG63C0XD.

Enzyme and pathway databases

UniPathwayi UPA00379 ; UER00551 .
BioCyci BABO262698:GJC2-2513-MONOMER.

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
HAMAPi MF_00372. HutI.
InterProi IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR01224. hutI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiHUTI_BRUAB
AccessioniPrimary (citable) accession number: Q579E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 10, 2005
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3