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Protein

D-amino acid dehydrogenase

Gene

dadA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Oxidative deamination of D-amino acids.UniRule annotation

Catalytic activityi

A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 1715FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. D-amino-acid dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2518-MONOMER.
UniPathwayiUPA00043; UER00498.

Names & Taxonomyi

Protein namesi
Recommended name:
D-amino acid dehydrogenaseUniRule annotation (EC:1.4.99.1UniRule annotation)
Gene namesi
Name:dadAUniRule annotation
Ordered Locus Names:BruAb2_0309
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416D-amino acid dehydrogenasePRO_1000066070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_0309.

Structurei

3D structure databases

ProteinModelPortaliQ579E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DadA oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0665.
HOGENOMiHOG000217450.
KOiK00285.
OMAiNDLYPRG.
OrthoDBiEOG6KMBD9.

Family and domain databases

HAMAPiMF_01202. DadA.
InterProiIPR023080. D-aa_DH_ssu_DadA.
IPR006076. FAD-dep_OxRdtase.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q579E2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MQITILGSGV IGVTTAYYLA KLGHEVTVID REEGPALETS FANAGQVSPG
60 70 80 90 100
YASPWAAPGI PLKAAKWLFQ KHAPLILRLT TDPVQYRWLL QMLANCTDSR
110 120 130 140 150
YKINKTRMVR VAEYSRDCLI ELRKDTGIEY DQRSQGTLQL FREQYQLDGI
160 170 180 190 200
GKDIEVLRQD GVPFEVLDRD GCVNVEPALA HAKDKFVGGL RLPNDETGDC
210 220 230 240 250
FKFTNALAKI AEGLGVKFRF GVNIKSLLMS GGKISGVETS EGIVTAERYV
260 270 280 290 300
VALGSYTPAL IKALGLNAPI YPVKGYSITA PIVDESRAPV STVLDESYKI
310 320 330 340 350
AITRLGDRIR VGGMAEVSGF TDDLPAARRA TLDLSVTDLF PGGDLKAATF
360 370 380 390 400
WSGLRPMTPD STPIIGGTRY DNLFINAGHG TLGWTMACGS GRLLADLISG
410
NKADIRADDL GIARYN
Length:416
Mass (Da):45,110
Last modified:May 10, 2005 - v1
Checksum:i7480382FF5614CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75742.1.
RefSeqiYP_223103.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75742; AAX75742; BruAb2_0309.
GeneIDi3341955.
KEGGibmb:BruAb2_0309.
PATRICi17826856. VBIBruAbo15061_2611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75742.1.
RefSeqiYP_223103.1. NC_006933.1.

3D structure databases

ProteinModelPortaliQ579E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb2_0309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75742; AAX75742; BruAb2_0309.
GeneIDi3341955.
KEGGibmb:BruAb2_0309.
PATRICi17826856. VBIBruAbo15061_2611.

Phylogenomic databases

eggNOGiCOG0665.
HOGENOMiHOG000217450.
KOiK00285.
OMAiNDLYPRG.
OrthoDBiEOG6KMBD9.

Enzyme and pathway databases

UniPathwayiUPA00043; UER00498.
BioCyciBABO262698:GJC2-2518-MONOMER.

Family and domain databases

HAMAPiMF_01202. DadA.
InterProiIPR023080. D-aa_DH_ssu_DadA.
IPR006076. FAD-dep_OxRdtase.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiDADA_BRUAB
AccessioniPrimary (citable) accession number: Q579E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.