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Protein

Probable aspartokinase

Gene

MJ0571

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Probable aspartokinase (MJ0571)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable aspartokinase (MJ0571)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Probable aspartokinase (MJ0571)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-612-MONOMER
BRENDAi2.7.2.4 3260
UniPathwayiUPA00034; UER00015
UPA00050; UER00461
UPA00051; UER00462

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aspartokinase (EC:2.7.2.4)
Alternative name(s):
Aspartate kinase
Gene namesi
Ordered Locus Names:MJ0571
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666881 – 473Probable aspartokinaseAdd BLAST473

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0571

Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Turni9 – 12Combined sources4
Helixi15 – 29Combined sources15
Beta strandi35 – 39Combined sources5
Helixi45 – 58Combined sources14
Helixi62 – 83Combined sources22
Helixi87 – 114Combined sources28
Helixi119 – 143Combined sources25
Beta strandi148 – 151Combined sources4
Helixi153 – 156Combined sources4
Beta strandi158 – 160Combined sources3
Beta strandi169 – 172Combined sources4
Helixi174 – 183Combined sources10
Beta strandi187 – 197Combined sources11
Beta strandi202 – 204Combined sources3
Turni207 – 209Combined sources3
Helixi210 – 220Combined sources11
Beta strandi224 – 234Combined sources11
Beta strandi236 – 238Combined sources3
Turni240 – 242Combined sources3
Beta strandi250 – 253Combined sources4
Helixi254 – 262Combined sources9
Beta strandi265 – 267Combined sources3
Helixi270 – 272Combined sources3
Helixi273 – 279Combined sources7
Beta strandi283 – 287Combined sources5
Beta strandi296 – 300Combined sources5
Beta strandi306 – 308Combined sources3
Beta strandi311 – 325Combined sources15
Beta strandi327 – 329Combined sources3
Helixi331 – 344Combined sources14
Beta strandi349 – 354Combined sources6
Beta strandi361 – 366Combined sources6
Helixi367 – 369Combined sources3
Helixi370 – 381Combined sources12
Beta strandi390 – 392Combined sources3
Beta strandi395 – 410Combined sources16
Turni412 – 416Combined sources5
Helixi420 – 431Combined sources12
Beta strandi437 – 442Combined sources6
Beta strandi444 – 452Combined sources9
Helixi453 – 455Combined sources3
Helixi456 – 467Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HMFX-ray2.70A/B/C/D2-470[»]
3C1MX-ray2.30A/B/C/D1-473[»]
3C1NX-ray2.72A/B/C/D1-473[»]
3C20X-ray2.70A/B1-473[»]
ProteinModelPortaliQ57991
SMRiQ57991
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57991

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini323 – 392ACT 1PROSITE-ProRule annotationAdd BLAST70
Domaini409 – 473ACT 2PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the aspartokinase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG00861 Archaea
COG0527 LUCA
InParanoidiQ57991
KOiK00928
OMAiINIMMIS
OrthoDBiPOG093Z042V
PhylomeDBiQ57991

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR002912 ACT_dom
IPR001048 Asp/Glu/Uridylate_kinase
IPR005260 Asp_kin_monofn
IPR001341 Asp_kinase
IPR018042 Aspartate_kinase_CS
IPR027795 CASTOR_ACT_dom
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01842 ACT, 1 hit
PF13840 ACT_7, 1 hit
PIRSFiPIRSF000726 Asp_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR00656 asp_kin_monofn, 1 hit
TIGR00657 asp_kinases, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 2 hits
PS00324 ASPARTOKINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q57991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVMKFGGT SVGSGERIRH VAKIVTKRKK EDDDVVVVVS AMSEVTNALV
60 70 80 90 100
EISQQALDVR DIAKVGDFIK FIREKHYKAI EEAIKSEEIK EEVKKIIDSR
110 120 130 140 150
IEELEKVLIG VAYLGELTPK SRDYILSFGE RLSSPILSGA IRDLGEKSIA
160 170 180 190 200
LEGGEAGIIT DNNFGSARVK RLEVKERLLP LLKEGIIPVV TGFIGTTEEG
210 220 230 240 250
YITTLGRGGS DYSAALIGYG LDADIIEIWT DVSGVYTTDP RLVPTARRIP
260 270 280 290 300
KLSYIEAMEL AYFGAKVLHP RTIEPAMEKG IPILVKNTFE PESEGTLITN
310 320 330 340 350
DMEMSDSIVK AISTIKNVAL INIFGAGMVG VSGTAARIFK ALGEEEVNVI
360 370 380 390 400
LISQGSSETN ISLVVSEEDV DKALKALKRE FGDFGKKSFL NNNLIRDVSV
410 420 430 440 450
DKDVCVISVV GAGMRGAKGI AGKIFTAVSE SGANIKMIAQ GSSEVNISFV
460 470
IDEKDLLNCV RKLHEKFIEK TNS
Length:473
Mass (Da):51,392
Last modified:November 1, 1996 - v1
Checksum:i811C6E0F4B66BC5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98565.1
PIRiC64371
RefSeqiWP_010870075.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98565; AAB98565; MJ_0571
GeneIDi1451436
KEGGimja:MJ_0571

Similar proteinsi

Entry informationi

Entry nameiAK_METJA
AccessioniPrimary (citable) accession number: Q57991
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health