Probable aspartokinase - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

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Q57991 (AK_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable aspartokinase
EC=2.7.2.4

Alternative name(s):
Aspartate kinase

Gene names

Ordered Locus Names:

MJ0571

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.

Sequence similarities

Belongs to the aspartokinase family.

Contains 2 ACT domains.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW amino acid binding Inferred from electronic annotation. Source: InterPro aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 473

473

Probable aspartokinase

PRO_0000066688

Regions

Domain

322 – 389

ACT 1

Domain

408 – 473

ACT 2

Secondary structure

473

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q57991 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 811C6E0F4B66BC5F
Show »

FASTA

473

51,392

        10         20         30         40         50         60 
MTTVMKFGGT SVGSGERIRH VAKIVTKRKK EDDDVVVVVS AMSEVTNALV EISQQALDVR 

        70         80         90        100        110        120 
DIAKVGDFIK FIREKHYKAI EEAIKSEEIK EEVKKIIDSR IEELEKVLIG VAYLGELTPK 

       130        140        150        160        170        180 
SRDYILSFGE RLSSPILSGA IRDLGEKSIA LEGGEAGIIT DNNFGSARVK RLEVKERLLP 

       190        200        210        220        230        240 
LLKEGIIPVV TGFIGTTEEG YITTLGRGGS DYSAALIGYG LDADIIEIWT DVSGVYTTDP 

       250        260        270        280        290        300 
RLVPTARRIP KLSYIEAMEL AYFGAKVLHP RTIEPAMEKG IPILVKNTFE PESEGTLITN 

       310        320        330        340        350        360 
DMEMSDSIVK AISTIKNVAL INIFGAGMVG VSGTAARIFK ALGEEEVNVI LISQGSSETN 

       370        380        390        400        410        420 
ISLVVSEEDV DKALKALKRE FGDFGKKSFL NNNLIRDVSV DKDVCVISVV GAGMRGAKGI 

       430        440        450        460        470 
AGKIFTAVSE SGANIKMIAQ GSSEVNISFV IDEKDLLNCV RKLHEKFIEK TNS

« Hide

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G.

Venter J.C.
Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L77117 Genomic DNA. Translation: AAB98565.1.

PIR

C64371.

RefSeq

NP_247550.1. NC_000909.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HMF	X-ray	2.70	A/B/C/D	2-470	[»]
3C1M	X-ray	2.30	A/B/C/D	1-473	[»]
3C1N	X-ray	2.72	A/B/C/D	1-473	[»]
3C20	X-ray	2.70	A/B	1-473	[»]

ProteinModelPortal

Q57991.

SMR

Q57991. Positions 2-470.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1451436.

GenomeReviews

Gene locus MJ0571 in contig L77117_GR.

KEGG

mja:MJ_0571.

NMPDR

fig|243232.1.peg.587.

TIGR

MJ0571.

Phylogenomic databases

HOGENOM

HBG724395.

OMA

QGSSETN.

ProtClustDB

PRK06291.

Enzyme and pathway databases

BioCyc

MJAN243232:MJ_0571-MONOMER.

Family and domain databases

InterPro

IPR002912. ACT-bd.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR005260. Asp_kin_monofn.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
[Graphical view]

Gene3D

G3DSA:3.40.1160.10. Aa_kinase. 2 hits.

K00928.

Pfam

PF00696. AA_kinase. 1 hit.
PF01842. ACT. 2 hits.
[Graphical view]

PIRSF

PIRSF000726. Asp_kin. 1 hit.

SUPFAM

SSF53633. Aa_kinase. 1 hit.

TIGRFAMs

TIGR00656. Asp_kin_monofn. 1 hit.
TIGR00657. Asp_kinases. 1 hit.

PROSITE

PS00324. ASPARTOKINASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

AK_METJA

Accession

Primary (citable) accession number: Q57991

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents