Reviewed, UniProtKB/Swiss-Prot Q57983 (MT51_METJA)

Names and origin

Protein names

Recommended name:
    Probable modification methylase MJ0563
    EC=2.1.1.37
Alternative name(s):
    Cytosine-specific methyltransferase MJ0563
    M.MjaVIIIP

Gene names

Ordered Locus Names:

MJ0563

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
Sequence similarities	Belongs to the C5-methyltransferase family.

Ontologies

Keywords
Biological process	Restriction system
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA methylation Inferred from electronic annotation. Source: InterPro DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA (cytosine-5-)-methyltransferase activity Inferred from electronic annotation. Source: EC DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Probable modification methylase MJ0563		PRO_0000087916
Sites
	Active site	77	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57983-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0F983B2193692D78	FASTA	310	36,290
	10 20 30 40 50 60 MNVIDLFSGC GGFSKGFLDE NFRILGAIEN FKPVVKTYLY NIKAPVWMDD IKRIPPKAFD 70 80 90 100 110 120 EFIKNEKVDV IIGSPPCEPF TKANKLIKDN PLDRLYKDKV GRLVLYYIDY VNYFTQRNDD 130 140 150 160 170 180 LIFVMENVPQ IKEIKDELKK LFGDIGHKVY FNILRAEDYG NPSKRARMFI SNIKLKPKKV 190 200 210 220 230 240 DKLVVVEEAL KDIPKDAKNH EIKKLSKEKV EMISKLKWGE ALYRYRGKKK LMFNWYKLHP 250 260 270 280 290 300 KKLAPTVKGR SRFIHPYEDR LLTVREQARL MSYPDDFVFF GGRDVQYNQI GESVPPILGR 310 AIAKEIKKQL

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L77117 Genomic DNA. Translation: AAB98555.1.
PIR	C64370.
RefSeq	NP_247542.1.
3D structure databases
HSSP	HSSP built from PDB template 1DCT based on UniProtKB P20589.
ModBase	Search...
Genome annotation databases
GeneID	1451428.
GenomeReviews	Gene locus MJ0563 in contig L77117_GR.
KEGG	mja:MJ0563.
NMPDR	fig|243232.1.peg.579.
TIGR	MJ0563.
Phylogenomic databases
HOGENOM	Q57983.
OMA	TAINSRR.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0563-MON.
BRENDA	2.1.1.37. 256362.
Family and domain databases
InterPro	IPR001525. C5_DNA_meth. IPR018117. C5_DNA_meth_AS. [Graphical view]
PANTHER	PTHR10629. C5_DNA_meth. 1 hit.
Pfam	PF00145. DNA_methylase. 2 hits. [Graphical view]
PRINTS	PR00105. C5METTRFRASE.
TIGRFAMs	TIGR00675. dcm. 1 hit.
PROSITE	PS00094. C5_MTASE_1. False negative. PS00095. C5_MTASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT51_METJA

Accession

Primary (citable) accession number: Q57983

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)