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Protein

Nicotinamide-nucleotide adenylyltransferase

Gene

MJ0541

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + nicotinamide ribonucleotide = diphosphate + NAD+.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide-nucleotide adenylyltransferase (MJ0541)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.1. 3260.
UniPathwayiUPA00253; UER00600.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide-nucleotide adenylyltransferase (EC:2.7.7.1)
Alternative name(s):
NAD(+) diphosphorylase
NAD(+) pyrophosphorylase
NMN adenylyltransferase
Gene namesi
Ordered Locus Names:MJ0541
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 168167Nicotinamide-nucleotide adenylyltransferasePRO_0000134992Add
BLAST

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRINGi243232.MJ_0541.

Structurei

Secondary structure

1
168
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Helixi14 – 2310Combined sources
Turni24 – 263Combined sources
Beta strandi28 – 347Combined sources
Beta strandi41 – 444Combined sources
Helixi49 – 6012Combined sources
Beta strandi66 – 716Combined sources
Helixi78 – 803Combined sources
Helixi81 – 888Combined sources
Beta strandi93 – 964Combined sources
Helixi100 – 1089Combined sources
Beta strandi112 – 1143Combined sources
Turni121 – 1233Combined sources
Helixi126 – 13510Combined sources
Helixi140 – 1423Combined sources
Helixi145 – 15410Combined sources
Helixi156 – 1638Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F9AX-ray2.00A/B/C/D/E/F2-168[»]
ProteinModelPortaliQ57961.
SMRiQ57961. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57961.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
InParanoidiQ57961.
KOiK00952.
OMAiNSVWVSH.
PhylomeDBiQ57961.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q57961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFIIGRFQ PFHKGHLEVI KKIAEEVDEI IIGIGSAQKS HTLENPFTAG
60 70 80 90 100
ERILMITQSL KDYDLTYYPI PIKDIEFNSI WVSYVESLTP PFDIVYSGNP
110 120 130 140 150
LVRVLFEERG YEVKRPEMFN RKEYSGTEIR RRMLNGEKWE HLVPKAVVDV
160
IKEIKGVERL RKLAQTDK
Length:168
Mass (Da):19,610
Last modified:January 23, 2007 - v3
Checksum:iD82FF45E68E29834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98533.1.
PIRiE64367.

Genome annotation databases

EnsemblBacteriaiAAB98533; AAB98533; MJ_0541.
KEGGimja:MJ_0541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98533.1.
PIRiE64367.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F9AX-ray2.00A/B/C/D/E/F2-168[»]
ProteinModelPortaliQ57961.
SMRiQ57961. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98533; AAB98533; MJ_0541.
KEGGimja:MJ_0541.

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
InParanoidiQ57961.
KOiK00952.
OMAiNSVWVSH.
PhylomeDBiQ57961.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00600.
BRENDAi2.7.7.1. 3260.

Miscellaneous databases

EvolutionaryTraceiQ57961.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADM_METJA
AccessioniPrimary (citable) accession number: Q57961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.