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Protein

TATA-box-binding protein

Gene

tbp

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
Box A-binding protein
Short name:
BAP
TATA sequence-binding protein
Short name:
TBP
TATA-box factor
Gene namesi
Name:tbp
Ordered Locus Names:MJ0507
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183TATA-box-binding proteinPRO_0000154008Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0507.

Structurei

Secondary structure

1
183
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 1810Combined sources
Helixi25 – 317Combined sources
Turni39 – 413Combined sources
Beta strandi45 – 495Combined sources
Turni50 – 534Combined sources
Beta strandi54 – 585Combined sources
Beta strandi62 – 7110Combined sources
Helixi72 – 8817Combined sources
Beta strandi100 – 10910Combined sources
Helixi116 – 1227Combined sources
Beta strandi126 – 1283Combined sources
Turni130 – 1323Combined sources
Beta strandi133 – 1408Combined sources
Turni141 – 1444Combined sources
Beta strandi145 – 1495Combined sources
Beta strandi153 – 1597Combined sources
Helixi163 – 18018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z8UX-ray1.90A/B/P/Q4-183[»]
ProteinModelPortaliQ57930.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57930.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 86771Add
BLAST
Repeati101 – 177772Add
BLAST

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01764. Archaea.
COG2101. LUCA.
InParanoidiQ57930.
KOiK03120.
OMAiMDCLEAI.
PhylomeDBiQ57930.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIMEPEIKI VNVVVSTKIG DNIDLEEVAM ILENAEYEPE QFPGLVCRLS
60 70 80 90 100
VPKVALLIFR SGKVNCTGAK SKEEAEIAIK KIIKELKDAG IDVIENPEIK
110 120 130 140 150
IQNMVATADL GIEPNLDDIA LMVEGTEYEP EQFPGLVYRL DDPKVVVLIF
160 170 180
GSGKVVITGL KSEEDAKRAL KKILDTIKEV QEL
Length:183
Mass (Da):20,233
Last modified:November 1, 1996 - v1
Checksum:i3C648FA0FC404944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98497.1.
PIRiC64363.

Genome annotation databases

EnsemblBacteriaiAAB98497; AAB98497; MJ_0507.
KEGGimja:MJ_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98497.1.
PIRiC64363.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z8UX-ray1.90A/B/P/Q4-183[»]
ProteinModelPortaliQ57930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98497; AAB98497; MJ_0507.
KEGGimja:MJ_0507.

Phylogenomic databases

eggNOGiarCOG01764. Archaea.
COG2101. LUCA.
InParanoidiQ57930.
KOiK03120.
OMAiMDCLEAI.
PhylomeDBiQ57930.

Miscellaneous databases

EvolutionaryTraceiQ57930.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Crystal structure of Methanococcus jannaschii TATA box-binding protein."
    Adachi N., Senda M., Natsume R., Senda T., Horikoshi M.
    Genes Cells 13:1127-1140(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 4-183.

Entry informationi

Entry nameiTBP_METJA
AccessioniPrimary (citable) accession number: Q57930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.