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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:MJ0451
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154403Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0451.

Structurei

3D structure databases

ProteinModelPortaliQ57893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
InParanoidiQ57893.
KOiK01817.
OMAiDTPREVD.
PhylomeDBiQ57893.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDDLVKVKI CGITNEEDIA YISKKVHAVG VIVDVPVKTP RKISLDKAIE
60 70 80 90 100
LKKYVAPFTS LVTVLMPNSI EEVLEIYNAL KPNAIQLHGF ESLDFVKELN
110 120 130 140 150
KLKNTGELNA HIIKVIHIPK DEEIDFKTLL NTAKEYEKYV EAILVDTKIE
160 170 180 190 200
SIKLEGKTHN WAVSKKLRES LEKPLILAGG LNKDNVLEAI KTVKPYAIDV
210 220
SSSLEAYGGK KDLKKVDEFL EVIKKV
Length:226
Mass (Da):25,306
Last modified:November 1, 1996 - v1
Checksum:i7B83DC1F16C5957E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98440.1.
PIRiC64356.
RefSeqiNP_247425.1. NC_000909.1.
WP_010869950.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98440; AAB98440; MJ_0451.
GeneIDi1451312.
KEGGimja:MJ_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98440.1.
PIRiC64356.
RefSeqiNP_247425.1. NC_000909.1.
WP_010869950.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ57893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ0451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98440; AAB98440; MJ_0451.
GeneIDi1451312.
KEGGimja:MJ_0451.

Phylogenomic databases

eggNOGiCOG0135.
InParanoidiQ57893.
KOiK01817.
OMAiDTPREVD.
PhylomeDBiQ57893.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiTRPF_METJA
AccessioniPrimary (citable) accession number: Q57893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.