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Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei263By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 29NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetyl-D-mannosamine dehydrogenase (EC:1.1.1.336)
Alternative name(s):
UDP-ManNAc 6-dehydrogenase
Gene namesi
Name:wecC
Ordered Locus Names:MJ0428
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740831 – 427UDP-N-acetyl-D-mannosamine dehydrogenaseAdd BLAST427

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_0428.

Structurei

3D structure databases

ProteinModelPortaliQ57871.
SMRiQ57871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00252. Archaea.
COG0677. LUCA.
InParanoidiQ57871.
KOiK02472.
OMAiGEKKCDL.
PhylomeDBiQ57871.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028359. UDP_ManNAc/GlcNAc_DH.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVEKNGIG KRICVIGLGY IGLPTASMLA IQGFDVIGVD INEKRVKEIK
60 70 80 90 100
ELSFKTTEKD LMTLVKGAIN SGNLKVQTKP EKADVFIICV PTPCIECDGE
110 120 130 140 150
KKCDLTYLNK AIESIKPYLE NGNLIIIEST IPPGTTDDIY KKLSKDKKIY
160 170 180 190 200
VAHCPERVLP GSILKELVEN DRVIGGVDEK SAEMAKEIYE TFVTGKIYLT
210 220 230 240 250
DAKTAEMVKL MENTYRDVNI ALANEFAKIA EEIGINVWEA IELANKHPRV
260 270 280 290 300
NILKPGPGVG GHCISIDPWF IVEKSKNAKL IRTARELNDS MPLFVVEKIK
310 320 330 340 350
KIIKKDIGKV AIFGVTYKGN VDDTRESPAE KVVSKLIDEG FEVKCYDKYA
360 370 380 390 400
RDFIYPLNSL DEAVEGADII VILAEHDEYK NFDKEDIKNI ASKVKNKIIL
410 420
DTKNILNREL WEKEGFKVYV LGDGKNA
Length:427
Mass (Da):47,749
Last modified:November 1, 1996 - v1
Checksum:i0F0EAAFC17F8BB76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98413.1.
PIRiD64353.
RefSeqiWP_010869927.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98413; AAB98413; MJ_0428.
GeneIDi1451288.
KEGGimja:MJ_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98413.1.
PIRiD64353.
RefSeqiWP_010869927.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ57871.
SMRiQ57871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98413; AAB98413; MJ_0428.
GeneIDi1451288.
KEGGimja:MJ_0428.

Phylogenomic databases

eggNOGiarCOG00252. Archaea.
COG0677. LUCA.
InParanoidiQ57871.
KOiK02472.
OMAiGEKKCDL.
PhylomeDBiQ57871.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028359. UDP_ManNAc/GlcNAc_DH.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWECC_METJA
AccessioniPrimary (citable) accession number: Q57871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.