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Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei209Proton donor/acceptorBy similarity1
Binding sitei209SubstrateBy similarity1
Binding sitei260Substrate; via amide nitrogenBy similarity1
Active sitei263NucleophileBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 29NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-458-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetyl-D-mannosamine dehydrogenase (EC:1.1.1.336By similarity)
Alternative name(s):
UDP-ManNAc 6-dehydrogenase
Gene namesi
Name:wecC
Ordered Locus Names:MJ0428
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740831 – 427UDP-N-acetyl-D-mannosamine dehydrogenaseAdd BLAST427

Proteomic databases

PRIDEiQ57871

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_0428

Structurei

3D structure databases

ProteinModelPortaliQ57871
SMRiQ57871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 158SubstrateBy similarity2
Regioni213 – 216SubstrateBy similarity4
Regioni247 – 249Substrate; shared with dimeric partnerBy similarity3
Regioni317 – 318SubstrateBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00252 Archaea
COG0677 LUCA
InParanoidiQ57871
KOiK02472
OMAiDPYYLAQ
OrthoDBiPOG093Z026D
PhylomeDBiQ57871

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028359 UDP_ManNAc/GlcNAc_DH
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500136 UDP_ManNAc_DH, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

Q57871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVEKNGIG KRICVIGLGY IGLPTASMLA IQGFDVIGVD INEKRVKEIK
60 70 80 90 100
ELSFKTTEKD LMTLVKGAIN SGNLKVQTKP EKADVFIICV PTPCIECDGE
110 120 130 140 150
KKCDLTYLNK AIESIKPYLE NGNLIIIEST IPPGTTDDIY KKLSKDKKIY
160 170 180 190 200
VAHCPERVLP GSILKELVEN DRVIGGVDEK SAEMAKEIYE TFVTGKIYLT
210 220 230 240 250
DAKTAEMVKL MENTYRDVNI ALANEFAKIA EEIGINVWEA IELANKHPRV
260 270 280 290 300
NILKPGPGVG GHCISIDPWF IVEKSKNAKL IRTARELNDS MPLFVVEKIK
310 320 330 340 350
KIIKKDIGKV AIFGVTYKGN VDDTRESPAE KVVSKLIDEG FEVKCYDKYA
360 370 380 390 400
RDFIYPLNSL DEAVEGADII VILAEHDEYK NFDKEDIKNI ASKVKNKIIL
410 420
DTKNILNREL WEKEGFKVYV LGDGKNA
Length:427
Mass (Da):47,749
Last modified:November 1, 1996 - v1
Checksum:i0F0EAAFC17F8BB76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98413.1
PIRiD64353
RefSeqiWP_010869927.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98413; AAB98413; MJ_0428
GeneIDi1451288
KEGGimja:MJ_0428

Similar proteinsi

Entry informationi

Entry nameiWECC_METJA
AccessioniPrimary (citable) accession number: Q57871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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