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Q57842 (MANB_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase

Short name=PMM
EC=5.4.2.8
Alternative name(s):
Phosphoglucomutase
Gene names
Name:manB
Ordered Locus Names:MJ0399
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of mannose-1-P from mannose-6-P. Can also use glucose-1-P. Ref.2

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the phosphohexose mutase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: InterPro

phosphomannomutase activity

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Phosphomannomutase
PRO_0000147831

Sites

Active site971Phosphoserine intermediate By similarity
Metal binding971Magnesium; via phosphate group By similarity
Metal binding2371Magnesium By similarity
Metal binding2391Magnesium By similarity
Metal binding2411Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57842 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1EB07EEAB409BA00

FASTA44951,474
        10         20         30         40         50         60 
MFGDLMVFKA YDIRGIYGRE LDENFAYSLG KCIGKKFENK KILVGNDVRI GSKELLPYFI 

        70         80         90        100        110        120 
VGLKEYADVF YAGTISTPLM YFGTKGKYDL GVILTASHNP PEYTGFKMCD KEAIPLSPIE 

       130        140        150        160        170        180 
EIKPIFKKYE LTESIKEEAK NLNLDDLKVN IIEEYKKFFL KRCKASDKKI AVDFANGATT 

       190        200        210        220        230        240 
IAEKEILNEL FDNAVFINDY PDGNFPAHQP DTLKMECLKD IIRAVKKNNC ELGLIFDGDG 

       250        260        270        280        290        300 
DRLGIVDENG NVLRGDILTA IIAKEILKEK SNAKIVYDLR CSKIVPEIIE KYGGIAIKSR 

       310        320        330        340        350        360 
VGHYFIKKLM HEIDAEFAGE LSNHFYFKEI GYFESPLLAL NYILKAMDEE NKSLSELNKE 

       370        380        390        400        410        420 
FSKYPHSGEI NFRVKDQKYI MEKIKEHFKD CKLEELDGIS IYCKNFWFNL RPSNTEPLLR 

       430        440 
LNLEADDEKT MKEKVEEIKN LIAKLDASL 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. expand/collapse author list , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]"Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii."
White R.H., Xu H.
Biochemistry 45:12366-12379(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A PHOSPHOMANNOMUTASE, SUBSTRATE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98388.1.
PIRG64349.
RefSeqNP_247373.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ57842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0399.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98388; AAB98388; MJ_0399.
GeneID1451259.
KEGGmja:MJ_0399.

Phylogenomic databases

eggNOGCOG1109.
KOK01840.
OMARPMNIAI.
PhylomeDBQ57842.

Family and domain databases

Gene3D3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSPR00509. PGMPMM.
SUPFAMSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANB_METJA
AccessionPrimary (citable) accession number: Q57842
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names