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Protein

Phosphomannomutase

Gene

manB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of mannose-1-P from mannose-6-P. Can also use glucose-1-P.1 Publication

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Phosphoserine intermediateBy similarity
Metal bindingi97 – 971Magnesium; via phosphate groupBy similarity
Metal bindingi237 – 2371MagnesiumBy similarity
Metal bindingi239 – 2391MagnesiumBy similarity
Metal bindingi241 – 2411MagnesiumBy similarity

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • phosphomannomutase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Alternative name(s):
Phosphoglucomutase
Gene namesi
Name:manB
Ordered Locus Names:MJ0399
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449PhosphomannomutasePRO_0000147831Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0399.

Structurei

3D structure databases

ProteinModelPortaliQ57842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
InParanoidiQ57842.
KOiK01840.
OMAiSIEYPNW.
PhylomeDBiQ57842.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGDLMVFKA YDIRGIYGRE LDENFAYSLG KCIGKKFENK KILVGNDVRI
60 70 80 90 100
GSKELLPYFI VGLKEYADVF YAGTISTPLM YFGTKGKYDL GVILTASHNP
110 120 130 140 150
PEYTGFKMCD KEAIPLSPIE EIKPIFKKYE LTESIKEEAK NLNLDDLKVN
160 170 180 190 200
IIEEYKKFFL KRCKASDKKI AVDFANGATT IAEKEILNEL FDNAVFINDY
210 220 230 240 250
PDGNFPAHQP DTLKMECLKD IIRAVKKNNC ELGLIFDGDG DRLGIVDENG
260 270 280 290 300
NVLRGDILTA IIAKEILKEK SNAKIVYDLR CSKIVPEIIE KYGGIAIKSR
310 320 330 340 350
VGHYFIKKLM HEIDAEFAGE LSNHFYFKEI GYFESPLLAL NYILKAMDEE
360 370 380 390 400
NKSLSELNKE FSKYPHSGEI NFRVKDQKYI MEKIKEHFKD CKLEELDGIS
410 420 430 440
IYCKNFWFNL RPSNTEPLLR LNLEADDEKT MKEKVEEIKN LIAKLDASL
Length:449
Mass (Da):51,474
Last modified:November 1, 1996 - v1
Checksum:i1EB07EEAB409BA00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98388.1.
PIRiG64349.
RefSeqiNP_247373.1. NC_000909.1.
WP_010869898.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98388; AAB98388; MJ_0399.
GeneIDi1451259.
KEGGimja:MJ_0399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98388.1.
PIRiG64349.
RefSeqiNP_247373.1. NC_000909.1.
WP_010869898.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ57842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ0399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98388; AAB98388; MJ_0399.
GeneIDi1451259.
KEGGimja:MJ_0399.

Phylogenomic databases

eggNOGiCOG1109.
InParanoidiQ57842.
KOiK01840.
OMAiSIEYPNW.
PhylomeDBiQ57842.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii."
    White R.H., Xu H.
    Biochemistry 45:12366-12379(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A PHOSPHOMANNOMUTASE, SUBSTRATE SPECIFICITY.

Entry informationi

Entry nameiMANB_METJA
AccessioniPrimary (citable) accession number: Q57842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.