Q57842 (MANB_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphomannomutase
Short name=PMM
EC=5.4.2.8

Alternative name(s):
Phosphoglucomutase

Gene names

Name:	manB
Ordered Locus Names:	MJ0399

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the formation of mannose-1-P from mannose-6-P. Can also use glucose-1-P. Ref.2
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphomannomutase activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Phosphomannomutase		PRO_0000147831
Sites
	Active site	97	1	Phosphoserine intermediate By similarity
	Metal binding	97	1	Magnesium; via phosphate group By similarity
	Metal binding	237	1	Magnesium By similarity
	Metal binding	239	1	Magnesium By similarity
	Metal binding	241	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57842 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1EB07EEAB409BA00	FASTA	449	51,474
	10 20 30 40 50 60 MFGDLMVFKA YDIRGIYGRE LDENFAYSLG KCIGKKFENK KILVGNDVRI GSKELLPYFI 70 80 90 100 110 120 VGLKEYADVF YAGTISTPLM YFGTKGKYDL GVILTASHNP PEYTGFKMCD KEAIPLSPIE 130 140 150 160 170 180 EIKPIFKKYE LTESIKEEAK NLNLDDLKVN IIEEYKKFFL KRCKASDKKI AVDFANGATT 190 200 210 220 230 240 IAEKEILNEL FDNAVFINDY PDGNFPAHQP DTLKMECLKD IIRAVKKNNC ELGLIFDGDG 250 260 270 280 290 300 DRLGIVDENG NVLRGDILTA IIAKEILKEK SNAKIVYDLR CSKIVPEIIE KYGGIAIKSR 310 320 330 340 350 360 VGHYFIKKLM HEIDAEFAGE LSNHFYFKEI GYFESPLLAL NYILKAMDEE NKSLSELNKE 370 380 390 400 410 420 FSKYPHSGEI NFRVKDQKYI MEKIKEHFKD CKLEELDGIS IYCKNFWFNL RPSNTEPLLR 430 440 LNLEADDEKT MKEKVEEIKN LIAKLDASL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii." White R.H., Xu H. Biochemistry 45:12366-12379(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A PHOSPHOMANNOMUTASE, SUBSTRATE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98388.1.
PIR	G64349.
RefSeq	NP_247373.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q57842.
ModBase	Search...
Protein-protein interaction databases
STRING	243232.MJ0399.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB98388; AAB98388; MJ_0399.
GeneID	1451259.
KEGG	mja:MJ_0399.
Phylogenomic databases
eggNOG	COG1109.
KO	K01840.
OMA	YDLRCSK.
ProtClustDB	CLSK876169.
Family and domain databases
Gene3D	3.40.120.10. 3 hits.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MANB_METJA

Accession

Primary (citable) accession number: Q57842

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program