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Protein

Cell division protein FtsZ 1

Gene

ftsZ1

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165GTPUniRule annotation3 Publications1
Binding sitei169GTPUniRule annotation2 Publications1
Binding sitei212GTPUniRule annotation3 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 48GTP3 Publications2
Nucleotide bindingi97 – 99GTP1 Publication3
Nucleotide bindingi134 – 136GTPUniRule annotation3 Publications3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-396-MONOMER
BRENDAi3.6.5.6 3260

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 1UniRule annotation
Gene namesi
Name:ftsZ1UniRule annotation
Ordered Locus Names:MJ0370
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144011 – 364Cell division protein FtsZ 1Add BLAST364

Proteomic databases

PRIDEiQ57816

Interactioni

Subunit structurei

Homodimer (PubMed:15558053). Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity).UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_0370

Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi24 – 34Combined sources11
Beta strandi40 – 45Combined sources6
Helixi46 – 59Combined sources14
Beta strandi64 – 72Combined sources9
Helixi73 – 77Combined sources5
Beta strandi82 – 86Combined sources5
Turni89 – 91Combined sources3
Beta strandi93 – 95Combined sources3
Helixi101 – 110Combined sources10
Helixi112 – 119Combined sources8
Beta strandi123 – 130Combined sources8
Helixi135 – 149Combined sources15
Beta strandi153 – 160Combined sources8
Helixi163 – 165Combined sources3
Helixi167 – 181Combined sources15
Beta strandi185 – 191Combined sources7
Helixi192 – 194Combined sources3
Helixi195 – 198Combined sources4
Beta strandi199 – 201Combined sources3
Helixi204 – 227Combined sources24
Helixi236 – 243Combined sources8
Beta strandi247 – 256Combined sources10
Beta strandi258 – 260Combined sources3
Helixi261 – 270Combined sources10
Helixi279 – 281Combined sources3
Beta strandi284 – 291Combined sources8
Helixi297 – 310Combined sources14
Beta strandi316 – 323Combined sources8
Turni326 – 329Combined sources4
Beta strandi331 – 338Combined sources8
Helixi341 – 343Combined sources3
Beta strandi344 – 347Combined sources4
Beta strandi350 – 353Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSZX-ray2.80A1-364[»]
1W58X-ray2.5011-364[»]
1W59X-ray2.70A/B1-364[»]
1W5AX-ray2.40A/B1-364[»]
1W5BX-ray2.20A/B1-364[»]
1W5EX-ray3.00A/B/C/D/E/F/G/H/I1-364[»]
2VAPX-ray1.70A1-364[»]
ProteinModelPortaliQ57816
SMRiQ57816
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57816

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
InParanoidiQ57816
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942
PhylomeDBiQ57816

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q57816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLKNVLEE GSKLEEFNEL ELSPEDKELL EYLQQTKAKI TVVGCGGAGN
60 70 80 90 100
NTITRLKMEG IEGAKTVAIN TDAQQLIRTK ADKKILIGKK LTRGLGAGGN
110 120 130 140 150
PKIGEEAAKE SAEEIKAAIQ DSDMVFITCG LGGGTGTGSA PVVAEISKKI
160 170 180 190 200
GALTVAVVTL PFVMEGKVRM KNAMEGLERL KQHTDTLVVI PNEKLFEIVP
210 220 230 240 250
NMPLKLAFKV ADEVLINAVK GLVELITKDG LINVDFADVK AVMNNGGLAM
260 270 280 290 300
IGIGESDSEK RAKEAVSMAL NSPLLDVDID GATGALIHVM GPEDLTLEEA
310 320 330 340 350
REVVATVSSR LDPNATIIWG ATIDENLENT VRVLLVITGV QSRIEFTDTG
360
LKRKKLELTG IPKI
Length:364
Mass (Da):38,924
Last modified:November 1, 1996 - v1
Checksum:i3BB386A5D2FCA107
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98359.1
PIRiB64346
RefSeqiWP_010869869.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98359; AAB98359; MJ_0370
GeneIDi1451227
KEGGimja:MJ_0370

Similar proteinsi

Entry informationi

Entry nameiFTSZ1_METJA
AccessioniPrimary (citable) accession number: Q57816
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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