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Protein

Cell division protein FtsZ 1

Gene

ftsZ1

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165GTPUniRule annotation3 Publications1
Binding sitei169GTPUniRule annotation2 Publications1
Binding sitei212GTPUniRule annotation3 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 48GTP3 Publications2
Nucleotide bindingi97 – 99GTP1 Publication3
Nucleotide bindingi134 – 136GTPUniRule annotation3 Publications3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.6. 3260.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 1UniRule annotation
Gene namesi
Name:ftsZ1UniRule annotation
Ordered Locus Names:MJ0370
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144011 – 364Cell division protein FtsZ 1Add BLAST364

Interactioni

Subunit structurei

Homodimer (PubMed:15558053). Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity).UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_0370.

Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi24 – 34Combined sources11
Beta strandi40 – 45Combined sources6
Helixi46 – 59Combined sources14
Beta strandi64 – 72Combined sources9
Helixi73 – 77Combined sources5
Beta strandi82 – 86Combined sources5
Turni89 – 91Combined sources3
Beta strandi93 – 95Combined sources3
Helixi101 – 110Combined sources10
Helixi112 – 119Combined sources8
Beta strandi123 – 130Combined sources8
Helixi135 – 149Combined sources15
Beta strandi153 – 160Combined sources8
Helixi163 – 165Combined sources3
Helixi167 – 181Combined sources15
Beta strandi185 – 191Combined sources7
Helixi192 – 194Combined sources3
Helixi195 – 198Combined sources4
Beta strandi199 – 201Combined sources3
Helixi204 – 227Combined sources24
Helixi236 – 243Combined sources8
Beta strandi247 – 256Combined sources10
Beta strandi258 – 260Combined sources3
Helixi261 – 270Combined sources10
Helixi279 – 281Combined sources3
Beta strandi284 – 291Combined sources8
Helixi297 – 310Combined sources14
Beta strandi316 – 323Combined sources8
Turni326 – 329Combined sources4
Beta strandi331 – 338Combined sources8
Helixi341 – 343Combined sources3
Beta strandi344 – 347Combined sources4
Beta strandi350 – 353Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSZX-ray2.80A1-364[»]
1W58X-ray2.5011-364[»]
1W59X-ray2.70A/B1-364[»]
1W5AX-ray2.40A/B1-364[»]
1W5BX-ray2.20A/B1-364[»]
1W5EX-ray3.00A/B/C/D/E/F/G/H/I1-364[»]
2VAPX-ray1.70A1-364[»]
ProteinModelPortaliQ57816.
SMRiQ57816.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57816.

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
InParanoidiQ57816.
KOiK03531.
OMAiGMAMMGI.
PhylomeDBiQ57816.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLKNVLEE GSKLEEFNEL ELSPEDKELL EYLQQTKAKI TVVGCGGAGN
60 70 80 90 100
NTITRLKMEG IEGAKTVAIN TDAQQLIRTK ADKKILIGKK LTRGLGAGGN
110 120 130 140 150
PKIGEEAAKE SAEEIKAAIQ DSDMVFITCG LGGGTGTGSA PVVAEISKKI
160 170 180 190 200
GALTVAVVTL PFVMEGKVRM KNAMEGLERL KQHTDTLVVI PNEKLFEIVP
210 220 230 240 250
NMPLKLAFKV ADEVLINAVK GLVELITKDG LINVDFADVK AVMNNGGLAM
260 270 280 290 300
IGIGESDSEK RAKEAVSMAL NSPLLDVDID GATGALIHVM GPEDLTLEEA
310 320 330 340 350
REVVATVSSR LDPNATIIWG ATIDENLENT VRVLLVITGV QSRIEFTDTG
360
LKRKKLELTG IPKI
Length:364
Mass (Da):38,924
Last modified:November 1, 1996 - v1
Checksum:i3BB386A5D2FCA107
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98359.1.
PIRiB64346.
RefSeqiWP_010869869.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98359; AAB98359; MJ_0370.
GeneIDi1451227.
KEGGimja:MJ_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98359.1.
PIRiB64346.
RefSeqiWP_010869869.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSZX-ray2.80A1-364[»]
1W58X-ray2.5011-364[»]
1W59X-ray2.70A/B1-364[»]
1W5AX-ray2.40A/B1-364[»]
1W5BX-ray2.20A/B1-364[»]
1W5EX-ray3.00A/B/C/D/E/F/G/H/I1-364[»]
2VAPX-ray1.70A1-364[»]
ProteinModelPortaliQ57816.
SMRiQ57816.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98359; AAB98359; MJ_0370.
GeneIDi1451227.
KEGGimja:MJ_0370.

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
InParanoidiQ57816.
KOiK03531.
OMAiGMAMMGI.
PhylomeDBiQ57816.

Enzyme and pathway databases

BRENDAi3.6.5.6. 3260.

Miscellaneous databases

EvolutionaryTraceiQ57816.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSZ1_METJA
AccessioniPrimary (citable) accession number: Q57816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.