Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q577Y1 (GLMS_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

EC=2.6.1.16
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene names
Name:glmS
Ordered Locus Names:BruAb2_0642
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity. HAMAP-Rule MF_00164

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. HAMAP-Rule MF_00164

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00164

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00164.

Sequence similarities

Contains 1 glutamine amidotransferase type-2 domain.

Contains 2 SIS domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing] HAMAP-Rule MF_00164
PRO_0000135308

Regions

Domain2 – 217216Glutamine amidotransferase type-2
Domain283 – 422140SIS 1
Domain455 – 597143SIS 2

Sites

Active site21Nucleophile; for GATase activity By similarity
Active site6021For Fru-6P isomerization activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q577Y1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: A1C65B027EF064DF

FASTA60766,288
        10         20         30         40         50         60 
MCGIIGIIGN DEVAPRLVDA LKRLEYRGYD SAGIATLQNG RLDRRRAEGK LVNLEKRLAG 

        70         80         90        100        110        120 
EPLPGVIGIG HTRWATHGRP VEHNAHPHIT TRLAVVHNGI IENFAELRAM LEAEGRKFET 

       130        140        150        160        170        180 
ETDTEAVAHL VTRELEKGKS PVEAVRDCLP HLKGAFALAF LFEGDEELLI GARQGPPLAV 

       190        200        210        220        230        240 
GYGEGEMFLG SDAIALAPFT DTISYLEDGD WAVLTRNGVS IYDENNKPVE RPVQKSQNTN 

       250        260        270        280        290        300 
MLVSKGNHRH FMQKEMFEQP EVISHTLANY LDFTTGKVRK EAIGIDFSKV DRLTITACGT 

       310        320        330        340        350        360 
AYYAATVAKY WFEQIARLPV DSDIASEFRY REMPLSKDSL AMFVSQSGET ADTLASLRYC 

       370        380        390        400        410        420 
KAQGLKIASV VNVTGSTIAR ESDAVFPTLA GPEIGVASTK AFTCQLSAMA SLAIAAARAR 

       430        440        450        460        470        480 
GAIDEVREQE LVHQLSEAPR FINQVLKLED QIAAVCHDLS KVNHVLYLGR GTSFPLAMEG 

       490        500        510        520        530        540 
ALKLKEISYI HAEGYAAGEL KHGPIALIDE TMPVIVIAPS DRLYEKTVSN MQEVAARGGR 

       550        560        570        580        590        600 
IILITDKKGA ESASIDTMAT IVLPEVPEFI SPLVYALPIQ MLAYHTAVLM GTDVDQPRNL 


AKSVTVE 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017224 Genomic DNA. Translation: AAX76053.1.
RefSeqYP_223414.1. NC_006933.1.

3D structure databases

ProteinModelPortalQ577Y1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb2_0642.

Protein family/group databases

MEROPSC44.971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX76053; AAX76053; BruAb2_0642.
GeneID3342276.
KEGGbmb:BruAb2_0642.
PATRIC17827565. VBIBruAbo15061_2956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0449.
HOGENOMHOG000258896.
KOK00820.
OMALGIGENF.
OrthoDBEOG6KT2Q1.
ProtClustDBPRK00331.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2857-MONOMER.

Family and domain databases

HAMAPMF_00164. GlmS.
InterProIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR001347. SIS.
[Graphical view]
PANTHERPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamPF01380. SIS. 2 hits.
[Graphical view]
TIGRFAMsTIGR01135. glmS. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLMS_BRUAB
AccessionPrimary (citable) accession number: Q577Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names