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Protein

Thioredoxin

Gene

trx

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts to maintain redox homeostasis; functions as a protein disulfide reductase.1 Publication

Redox potential

E0 is -277 mV.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Gene namesi
Name:trx
Ordered Locus Names:MJ0307
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585ThioredoxinPRO_0000141645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi14 ↔ 17Redox-active

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0307.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107Combined sources
Helixi20 – 3011Combined sources
Beta strandi32 – 4514Combined sources
Turni48 – 503Combined sources
Turni52 – 543Combined sources
Beta strandi57 – 626Combined sources
Beta strandi65 – 673Combined sources
Beta strandi70 – 745Combined sources
Helixi75 – 8410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FO5NMR-A1-85[»]
ProteinModelPortaliQ57755.
SMRiQ57755. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57755.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiarCOG01972. Archaea.
COG0526. LUCA.
InParanoidiQ57755.
OMAiYGIMAVP.
PhylomeDBiQ57755.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR004502. Thio_glut.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF13192. Thioredoxin_3. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00411. redox_disulf_1. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVKIELFT SPMCPHCPAA KRVVEEVANE MPDAVEVEYI NVMENPQKAM
60 70 80
EYGIMAVPTI VINGDVEFIG APTKEALVEA IKKRL
Length:85
Mass (Da):9,404
Last modified:November 1, 1996 - v1
Checksum:iA38309843CD81A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98293.1.
PIRiD64338.

Genome annotation databases

EnsemblBacteriaiAAB98293; AAB98293; MJ_0307.
KEGGimja:MJ_0307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98293.1.
PIRiD64338.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FO5NMR-A1-85[»]
ProteinModelPortaliQ57755.
SMRiQ57755. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98293; AAB98293; MJ_0307.
KEGGimja:MJ_0307.

Phylogenomic databases

eggNOGiarCOG01972. Archaea.
COG0526. LUCA.
InParanoidiQ57755.
OMAiYGIMAVP.
PhylomeDBiQ57755.

Miscellaneous databases

EvolutionaryTraceiQ57755.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR004502. Thio_glut.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF13192. Thioredoxin_3. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00411. redox_disulf_1. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHIO_METJA
AccessioniPrimary (citable) accession number: Q57755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.