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Q57710 (IF2P_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable translation initiation factor IF-2

Cleaved into the following chain:

  1. Mja infB intein
    Alternative name(s):
    Mja IF2 intein
Gene names
Name:infB
Ordered Locus Names:MJ0262
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length1155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity. HAMAP-Rule MF_00100_A

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential. HAMAP-Rule MF_00100_A

Miscellaneous

The intein interrupts the GTP-binding site. HAMAP-Rule MF_00100_A

Sequence similarities

Belongs to the IF-2 family.

Contains 1 DOD-type homing endonuclease domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3030Probable translation initiation factor IF-2, 1st part Potential
PRO_0000014484
Chain31 – 576546Mja infB intein Potential
PRO_0000014485
Chain577 – 1155579Probable translation initiation factor IF-2, 2nd part Potential
PRO_0000014486

Regions

Domain237 – 367131DOD-type homing endonuclease
Nucleotide binding634 – 6385GTP By similarity
Nucleotide binding688 – 6914GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57710 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6653FA355E7EE0D3

FASTA1,155132,299
        10         20         30         40         50         60 
MAKKNTKKDN KNQNLRCPIV CVLGHVDHGK CLMPHEKVLT EYGEIKIEDL FKIGKEIVEK 

        70         80         90        100        110        120 
DELKEIRKLN IKVHTLNENG EIKIINAPYV WKLKHKGKMI KVKLKNWHSI TTTPEHPFLT 

       130        140        150        160        170        180 
NNGWIKAENI KKGMYVAIPR KIYGNEDFEK FIEFINSKIL TNELIVKVNE KDLKNVELPS 

       190        200        210        220        230        240 
TKIYKKQKNV FRSEDIIEHN LNIEKISFSP RIHRCGKPQH YIKLPKSLNE WKAIFYFAGV 

       250        260        270        280        290        300 
MFGDGCVDRI ANNDEEVFNK LKSLNNLGIE VERIKRKSSY EIIFKNGKNA LINLLKILFD 

       310        320        330        340        350        360 
YPSEKKSHNI KIPQILYIAP KELVAEFIKG YFDADGYVNL RQNRIEVISA SKEFIEGLSI 

       370        380        390        400        410        420 
LLLRFEITSK IYEIKKSYKE TKKKYYQLNI VGKRNLKNFK NIGFSIKYKE ENLNKIIEKS 

       430        440        450        460        470        480 
RKSEKYPINK DMKRLRILFG MTRNEVNVSY YAKYENGKEI PSYEIVKKFL NSLKPKNLDK 

       490        500        510        520        530        540 
KIKVLEGKER DVNYLKAFES DGLIENGRLT KLGREALNIW KNHEFGKENI DYMKSLIENI 

       550        560        570        580        590        600 
AFVEVEDVEI IDYDGYVYDL TTETHNFIAN GIVVHNTTLL DKIRKTRVAK REAGGITQHI 

       610        620        630        640        650        660 
GASEIPIDVI KRLCGDLLKM LKADLKIPGL LVIDTPGHEA FTSLRKRGGA LADIAILVVD 

       670        680        690        700        710        720 
INEGFKPQTV EAVNILRQCK TPFVVAANKI DLIPGWNSKE GPFILNFNEK NQHPNALTEF 

       730        740        750        760        770        780 
EIRLYENIIK PLNELGFDAD LYSRVQDVTK TVCIIPVSAV TGEGIPDLLM MVAGLAQKFL 

       790        800        810        820        830        840 
EDRLKLNVEG YAKGTILEVK EEKGLGTTID AIIYDGIAKR GDYLVVGLPD DVLVTRVKAL 

       850        860        870        880        890        900 
LKPKPLDEMR DPRDKFKPVN EVTAAAGVKI AAPELDKVIA GCPIRIVPKD KIEEAKEEVM 

       910        920        930        940        950        960 
KEVEEAKIEV DDEGILIKAD TLGSLEALAN ELRKAGVKIK KAEVGDVTKK DVIEVASYKQ 

       970        980        990       1000       1010       1020 
SNPLHGAIVA FNVKILPEAQ KEIEKYDIKV FLDNIIYKLV EDFTEWIKKE EERIKYGEFE 

      1030       1040       1050       1060       1070       1080 
KLIKPAIIRI LPDCIFRQKD PAICGVEVLC GTLRVGAPLM REDGMQLGYV REIKDRGENV 

      1090       1100       1110       1120       1130       1140 
KEAKAGKAVS IAIDGRVVLK RHVDEGDYMY VAVPESHVRE LYHKYMDRLR NDEKEALLRY 

      1150 
MELMQKLTNN IFWGR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB98248.1.
PIRG64332.
RefSeqNP_247234.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ57710.
ModBaseSearch...

Protein-protein interaction databases

STRING243232.MJ0262.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98248; AAB98248; MJ_0262.
GeneID1451116.
KEGGmja:MJ_0262.

Phylogenomic databases

eggNOGCOG0532.
KOK03243.
OMAEVWRNRE.
ProtClustDBPRK14845.

Family and domain databases

Gene3D3.10.28.10. 1 hit.
3.40.50.10050. 1 hit.
HAMAPMF_00100_A. IF-2_A.
InterProIPR000795. EF_GTP-bd_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR009000. Transl_elong_init/rib_B-barrel.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSPR00379. INTEIN.
SMARTSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF55608. SSF55608. 1 hit.
SSF52156. TIF_IF2_dom3. 1 hit.
SSF50447. Translat_factor. 1 hit.
TIGRFAMsTIGR00491. aIF-2. 1 hit.
TIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. False negative.
PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2P_METJA
AccessionPrimary (citable) accession number: Q57710
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Intein-containing proteins

List of intein-containing protein entries

Translation initiation factors

List of translation initiation factor entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

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