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Q57710

- IF2P_METJA

UniProt

Q57710 - IF2P_METJA

Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi634 – 6385GTPBy similarity
    Nucleotide bindingi688 – 6914GTPBy similarity

    GO - Molecular functioni

    1. endonuclease activity Source: InterPro
    2. GTPase activity Source: InterPro
    3. GTP binding Source: UniProtKB-KW
    4. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. intein-mediated protein splicing Source: InterPro

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable translation initiation factor IF-2
    Cleaved into the following chain:
    Alternative name(s):
    Mja IF2 intein
    Gene namesi
    Name:infB
    Ordered Locus Names:MJ0262
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3030Probable translation initiation factor IF-2, 1st partSequence AnalysisPRO_0000014484Add
    BLAST
    Chaini31 – 576546Mja infB inteinSequence AnalysisPRO_0000014485Add
    BLAST
    Chaini577 – 1155579Probable translation initiation factor IF-2, 2nd partSequence AnalysisPRO_0000014486Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0262.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57710.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini237 – 367131DOD-type homing endonucleaseAdd
    BLAST
    Domaini561 – 781221tr-type GAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    KOiK03243.
    OMAiDHGKCLL.
    PhylomeDBiQ57710.

    Family and domain databases

    Gene3Di2.170.16.10. 2 hits.
    3.10.28.10. 1 hit.
    3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_A. IF_2_A.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR029459. EFTU-type.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR006142. INTEIN.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004544. TIF_aIF-2_arc.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF14578. GTP_EFTU_D4. 1 hit.
    PF11987. IF-2. 1 hit.
    PF14528. LAGLIDADG_3. 1 hit.
    [Graphical view]
    PRINTSiPR00379. INTEIN.
    SMARTiSM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF51294. SSF51294. 3 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55608. SSF55608. 1 hit.
    TIGRFAMsiTIGR00491. aIF-2. 1 hit.
    TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50819. INTEIN_ENDONUCLEASE. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q57710-1 [UniParc]FASTAAdd to Basket

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    MAKKNTKKDN KNQNLRCPIV CVLGHVDHGK CLMPHEKVLT EYGEIKIEDL     50
    FKIGKEIVEK DELKEIRKLN IKVHTLNENG EIKIINAPYV WKLKHKGKMI 100
    KVKLKNWHSI TTTPEHPFLT NNGWIKAENI KKGMYVAIPR KIYGNEDFEK 150
    FIEFINSKIL TNELIVKVNE KDLKNVELPS TKIYKKQKNV FRSEDIIEHN 200
    LNIEKISFSP RIHRCGKPQH YIKLPKSLNE WKAIFYFAGV MFGDGCVDRI 250
    ANNDEEVFNK LKSLNNLGIE VERIKRKSSY EIIFKNGKNA LINLLKILFD 300
    YPSEKKSHNI KIPQILYIAP KELVAEFIKG YFDADGYVNL RQNRIEVISA 350
    SKEFIEGLSI LLLRFEITSK IYEIKKSYKE TKKKYYQLNI VGKRNLKNFK 400
    NIGFSIKYKE ENLNKIIEKS RKSEKYPINK DMKRLRILFG MTRNEVNVSY 450
    YAKYENGKEI PSYEIVKKFL NSLKPKNLDK KIKVLEGKER DVNYLKAFES 500
    DGLIENGRLT KLGREALNIW KNHEFGKENI DYMKSLIENI AFVEVEDVEI 550
    IDYDGYVYDL TTETHNFIAN GIVVHNTTLL DKIRKTRVAK REAGGITQHI 600
    GASEIPIDVI KRLCGDLLKM LKADLKIPGL LVIDTPGHEA FTSLRKRGGA 650
    LADIAILVVD INEGFKPQTV EAVNILRQCK TPFVVAANKI DLIPGWNSKE 700
    GPFILNFNEK NQHPNALTEF EIRLYENIIK PLNELGFDAD LYSRVQDVTK 750
    TVCIIPVSAV TGEGIPDLLM MVAGLAQKFL EDRLKLNVEG YAKGTILEVK 800
    EEKGLGTTID AIIYDGIAKR GDYLVVGLPD DVLVTRVKAL LKPKPLDEMR 850
    DPRDKFKPVN EVTAAAGVKI AAPELDKVIA GCPIRIVPKD KIEEAKEEVM 900
    KEVEEAKIEV DDEGILIKAD TLGSLEALAN ELRKAGVKIK KAEVGDVTKK 950
    DVIEVASYKQ SNPLHGAIVA FNVKILPEAQ KEIEKYDIKV FLDNIIYKLV 1000
    EDFTEWIKKE EERIKYGEFE KLIKPAIIRI LPDCIFRQKD PAICGVEVLC 1050
    GTLRVGAPLM REDGMQLGYV REIKDRGENV KEAKAGKAVS IAIDGRVVLK 1100
    RHVDEGDYMY VAVPESHVRE LYHKYMDRLR NDEKEALLRY MELMQKLTNN 1150
    IFWGR 1155
    Length:1,155
    Mass (Da):132,299
    Last modified:November 1, 1996 - v1
    Checksum:i6653FA355E7EE0D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98248.1.
    PIRiG64332.
    RefSeqiNP_247234.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98248; AAB98248; MJ_0262.
    GeneIDi1451116.
    KEGGimja:MJ_0262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98248.1 .
    PIRi G64332.
    RefSeqi NP_247234.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q57710.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0262.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98248 ; AAB98248 ; MJ_0262 .
    GeneIDi 1451116.
    KEGGi mja:MJ_0262.

    Phylogenomic databases

    eggNOGi COG0532.
    KOi K03243.
    OMAi DHGKCLL.
    PhylomeDBi Q57710.

    Family and domain databases

    Gene3Di 2.170.16.10. 2 hits.
    3.10.28.10. 1 hit.
    3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_A. IF_2_A.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR029459. EFTU-type.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR006142. INTEIN.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004544. TIF_aIF-2_arc.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF14578. GTP_EFTU_D4. 1 hit.
    PF11987. IF-2. 1 hit.
    PF14528. LAGLIDADG_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00379. INTEIN.
    SMARTi SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF51294. SSF51294. 3 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55608. SSF55608. 1 hit.
    TIGRFAMsi TIGR00491. aIF-2. 1 hit.
    TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50819. INTEIN_ENDONUCLEASE. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiIF2P_METJA
    AccessioniPrimary (citable) accession number: Q57710
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The intein interrupts the GTP-binding site.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3