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Q57710

- IF2P_METJA

UniProt

Q57710 - IF2P_METJA

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Protein
Probable translation initiation factor IF-2
Gene
infB, MJ0262
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi634 – 6385GTP By similarity
Nucleotide bindingi688 – 6914GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. endonuclease activity Source: InterPro
  4. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2
Cleaved into the following chain:
Alternative name(s):
Mja IF2 intein
Gene namesi
Name:infB
Ordered Locus Names:MJ0262
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3030Probable translation initiation factor IF-2, 1st part Reviewed prediction
PRO_0000014484Add
BLAST
Chaini31 – 576546Mja infB intein Reviewed prediction
PRO_0000014485Add
BLAST
Chaini577 – 1155579Probable translation initiation factor IF-2, 2nd part Reviewed prediction
PRO_0000014486Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.UniRule annotation

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0262.

Structurei

3D structure databases

ProteinModelPortaliQ57710.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini237 – 367131DOD-type homing endonuclease
Add
BLAST
Domaini561 – 781221tr-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
KOiK03243.
OMAiDHGKCLL.
PhylomeDBiQ57710.

Family and domain databases

Gene3Di2.170.16.10. 2 hits.
3.10.28.10. 1 hit.
3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR000795. EF_GTP-bd_dom.
IPR029459. EFTU-type.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view]
PRINTSiPR00379. INTEIN.
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF51294. SSF51294. 3 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55608. SSF55608. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q57710-1 [UniParc]FASTAAdd to Basket

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MAKKNTKKDN KNQNLRCPIV CVLGHVDHGK CLMPHEKVLT EYGEIKIEDL     50
FKIGKEIVEK DELKEIRKLN IKVHTLNENG EIKIINAPYV WKLKHKGKMI 100
KVKLKNWHSI TTTPEHPFLT NNGWIKAENI KKGMYVAIPR KIYGNEDFEK 150
FIEFINSKIL TNELIVKVNE KDLKNVELPS TKIYKKQKNV FRSEDIIEHN 200
LNIEKISFSP RIHRCGKPQH YIKLPKSLNE WKAIFYFAGV MFGDGCVDRI 250
ANNDEEVFNK LKSLNNLGIE VERIKRKSSY EIIFKNGKNA LINLLKILFD 300
YPSEKKSHNI KIPQILYIAP KELVAEFIKG YFDADGYVNL RQNRIEVISA 350
SKEFIEGLSI LLLRFEITSK IYEIKKSYKE TKKKYYQLNI VGKRNLKNFK 400
NIGFSIKYKE ENLNKIIEKS RKSEKYPINK DMKRLRILFG MTRNEVNVSY 450
YAKYENGKEI PSYEIVKKFL NSLKPKNLDK KIKVLEGKER DVNYLKAFES 500
DGLIENGRLT KLGREALNIW KNHEFGKENI DYMKSLIENI AFVEVEDVEI 550
IDYDGYVYDL TTETHNFIAN GIVVHNTTLL DKIRKTRVAK REAGGITQHI 600
GASEIPIDVI KRLCGDLLKM LKADLKIPGL LVIDTPGHEA FTSLRKRGGA 650
LADIAILVVD INEGFKPQTV EAVNILRQCK TPFVVAANKI DLIPGWNSKE 700
GPFILNFNEK NQHPNALTEF EIRLYENIIK PLNELGFDAD LYSRVQDVTK 750
TVCIIPVSAV TGEGIPDLLM MVAGLAQKFL EDRLKLNVEG YAKGTILEVK 800
EEKGLGTTID AIIYDGIAKR GDYLVVGLPD DVLVTRVKAL LKPKPLDEMR 850
DPRDKFKPVN EVTAAAGVKI AAPELDKVIA GCPIRIVPKD KIEEAKEEVM 900
KEVEEAKIEV DDEGILIKAD TLGSLEALAN ELRKAGVKIK KAEVGDVTKK 950
DVIEVASYKQ SNPLHGAIVA FNVKILPEAQ KEIEKYDIKV FLDNIIYKLV 1000
EDFTEWIKKE EERIKYGEFE KLIKPAIIRI LPDCIFRQKD PAICGVEVLC 1050
GTLRVGAPLM REDGMQLGYV REIKDRGENV KEAKAGKAVS IAIDGRVVLK 1100
RHVDEGDYMY VAVPESHVRE LYHKYMDRLR NDEKEALLRY MELMQKLTNN 1150
IFWGR 1155
Length:1,155
Mass (Da):132,299
Last modified:November 1, 1996 - v1
Checksum:i6653FA355E7EE0D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98248.1.
PIRiG64332.
RefSeqiNP_247234.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98248; AAB98248; MJ_0262.
GeneIDi1451116.
KEGGimja:MJ_0262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98248.1 .
PIRi G64332.
RefSeqi NP_247234.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q57710.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0262.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98248 ; AAB98248 ; MJ_0262 .
GeneIDi 1451116.
KEGGi mja:MJ_0262.

Phylogenomic databases

eggNOGi COG0532.
KOi K03243.
OMAi DHGKCLL.
PhylomeDBi Q57710.

Family and domain databases

Gene3Di 2.170.16.10. 2 hits.
3.10.28.10. 1 hit.
3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_A. IF_2_A.
InterProi IPR000795. EF_GTP-bd_dom.
IPR029459. EFTU-type.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view ]
PRINTSi PR00379. INTEIN.
SMARTi SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF51294. SSF51294. 3 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55608. SSF55608. 1 hit.
TIGRFAMsi TIGR00491. aIF-2. 1 hit.
TIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiIF2P_METJA
AccessioniPrimary (citable) accession number: Q57710
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The intein interrupts the GTP-binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi