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Q57700

- PYRF_METJA

UniProt

Q57700 - PYRF_METJA

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, MJ0252
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Substrate By similarity
Binding sitei31 – 311Substrate By similarity
Active sitei61 – 611Proton donor By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei191 – 1911Substrate; via amide nitrogen By similarity
Binding sitei192 – 1921Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:MJ0252
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134610Add
BLAST

Proteomic databases

PRIDEiQ57700.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243232.MJ0252.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75
Helixi13 – 2311
Turni24 – 263
Beta strandi28 – 336
Helixi34 – 385
Helixi43 – 5210
Beta strandi54 – 629
Helixi66 – 7611
Turni77 – 793
Beta strandi81 – 877
Helixi91 – 10313
Beta strandi107 – 1115
Helixi117 – 1204
Turni121 – 1233
Helixi124 – 1263
Helixi127 – 13711
Beta strandi140 – 1434
Helixi149 – 15911
Beta strandi163 – 1664
Helixi175 – 1773
Helixi179 – 1813
Beta strandi187 – 1904
Helixi192 – 1954
Helixi200 – 20910

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LUIX-ray1.60A/B1-213[»]
4LUJX-ray1.60A/B1-213[»]
ProteinModelPortaliQ57700.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate binding By similarity
Regioni166 – 17611Substrate binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiTEMSHPG.
PhylomeDBiQ57700.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_A. OMPdecase_type1_A.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57700-1 [UniParc]FASTAAdd to Basket

« Hide

MPKLMLALDV LDRDRALKIV EDVKDYVDAI KVGYPLVLST GTEIIKEIKK    50
LCNKEVIADF KVADIPATNE KIAKITLKYA DGIIVHGFVG EDSVKAVQDV 100
AKKLNKKVIM VTEMSHPGAV QFLQPIADKL SEMAKKLKVD AIVAPSTRPE 150
RLKEIKEIAE LPVITPGVGA QGGKIEDILN ILDENDYVIV GRAIYQSQNP 200
KEEAKKYKEM LNK 213
Length:213
Mass (Da):23,592
Last modified:January 23, 2002 - v2
Checksum:i0B073BE37D50C556
GO

Sequence cautioni

The sequence AAB98239.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98239.1. Different initiation.
PIRiE64331.
RefSeqiNP_247223.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98239; AAB98239; MJ_0252.
GeneIDi1451106.
KEGGimja:MJ_0252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98239.1 . Different initiation.
PIRi E64331.
RefSeqi NP_247223.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LUI X-ray 1.60 A/B 1-213 [» ]
4LUJ X-ray 1.60 A/B 1-213 [» ]
ProteinModelPortali Q57700.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0252.

Proteomic databases

PRIDEi Q57700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98239 ; AAB98239 ; MJ_0252 .
GeneIDi 1451106.
KEGGi mja:MJ_0252.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi TEMSHPG.
PhylomeDBi Q57700.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_A. OMPdecase_type1_A.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiPYRF_METJA
AccessioniPrimary (citable) accession number: Q57700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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