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Q57700 (PYRF_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:MJ0252
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Sequence caution

The sequence AAB98239.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134610

Regions

Region59 – 6810Substrate binding By similarity
Region166 – 17611Substrate binding By similarity

Sites

Active site611Proton donor By similarity
Binding site91Substrate By similarity
Binding site311Substrate By similarity
Binding site1151Substrate By similarity
Binding site1911Substrate; via amide nitrogen By similarity
Binding site1921Substrate By similarity

Secondary structure

........................................... 213
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q57700 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 0B073BE37D50C556

FASTA21323,592
        10         20         30         40         50         60 
MPKLMLALDV LDRDRALKIV EDVKDYVDAI KVGYPLVLST GTEIIKEIKK LCNKEVIADF 

        70         80         90        100        110        120 
KVADIPATNE KIAKITLKYA DGIIVHGFVG EDSVKAVQDV AKKLNKKVIM VTEMSHPGAV 

       130        140        150        160        170        180 
QFLQPIADKL SEMAKKLKVD AIVAPSTRPE RLKEIKEIAE LPVITPGVGA QGGKIEDILN 

       190        200        210 
ILDENDYVIV GRAIYQSQNP KEEAKKYKEM LNK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98239.1. Different initiation.
PIRE64331.
RefSeqNP_247223.1. NC_000909.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4LUIX-ray1.60A/B1-213[»]
4LUJX-ray1.60A/B1-213[»]
ProteinModelPortalQ57700.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0252.

Proteomic databases

PRIDEQ57700.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98239; AAB98239; MJ_0252.
GeneID1451106.
KEGGmja:MJ_0252.

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMATEMSHPG.
PhylomeDBQ57700.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_METJA
AccessionPrimary (citable) accession number: Q57700
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names