Q576S3 (UPPP_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	BruAb2_0982

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151119
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	46 – 66	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	107 – 127	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	213 – 233	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q576S3 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 10A3AFD1330B2CAD	FASTA	268	29,169
	10 20 30 40 50 60 MDFFNLLEAA FLGLIEGLTE FIPVSSTGHL LLIGHFLGFE STGKTFEVLI QLGAILAILS 70 80 90 100 110 120 VYSAKLARIA TDFPRDARTR RFVLGVLVAF LPAAVIGALA HGFIKGVLFE TPMLVCIMLI 130 140 150 160 170 180 VGGFILLWVD QLNLRPRYHN VMDYPLPICL AIGFIQCLAM IPGVSRSGST IVGSLLLGAD 190 200 210 220 230 240 KRSAAEFSFF LAMPTMAGAF AYDLFKSRNI LSFNDGALIV VGFIMAFISG VFVVRHLLDY 250 260 VSRHGFALFG WWRLIVGSAG MAALIIWG

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017224 Genomic DNA. Translation: AAX76361.1.
RefSeq	YP_223722.1. NC_006933.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb2_0982.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX76361; AAX76361; BruAb2_0982.
GeneID	3341506.
KEGG	bmb:BruAb2_0982.
PATRIC	17828278. VBIBruAbo15061_3308.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	PERENVT.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-3201-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_BRUAB

Accession

Primary (citable) accession number: Q576S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program