Reviewed, UniProtKB/Swiss-Prot Q576R4 (DAPB_BRUAB)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BruAb2_0991

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Dihydrodipicolinate reductase		PRO_0000228330

Sequences

	Sequence		Length	Mass (Da)
	Q576R4-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 1D48EC7280B56A17	FASTA	268	27,605
	10 20 30 40 50 60 MGLVVVGAGG RMGQTLIRTI QSIEGAKLVG AIERSGSPFL GKDAGEVTGI GTLGVAITDD 70 80 90 100 110 120 PLPVFAKAHG VLDFTSPAAS VEFAGLAAQA RIVHVIGTTG CSAEDDEKIR AAARHATIVK 130 140 150 160 170 180 SGNMSLGVNL LSVLVQKAAE ALGPEDFDIE ILEMHHRHKV DAPSGTALLL GEAAARGRDI 190 200 210 220 230 240 ALADNSVRVR DGYTGPRETG AIGFATLRGG SVIGDHSVIL AGTGERVVLS HHAEDRSIFA 250 260 RGAIKAALWA HGKKPGLYSM LDVLGLNT

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017224 Genomic DNA. Translation: AAX76370.1.
RefSeq	YP_223731.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3341712.
GenomeReviews	Gene locus BruAb2_0991 in contig AE017224_GR.
KEGG	bmb:BruAb2_0991.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q576R4.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB2_0991-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. [Graphical view]
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BRUAB

Accession

Primary (citable) accession number: Q576R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)