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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

coaBC

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotationImported, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Name:coaBCImported
Ordered Locus Names:BruAb2_1004Imported
OrganismiBrucella abortus biovar 1 (strain 9-941)Imported
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome II

Structurei

3D structure databases

ProteinModelPortaliQ576Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 180FlavoproteinInterPro annotationAdd BLAST174
Domaini189 – 375DFPInterPro annotationAdd BLAST187

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000037526.
KOiK13038.
OMAiVRFIGNH.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q576Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLDGKRIL LIIGGGIAAY KTPDLIRRLR ERGAHVRPLM TAAAQQFVTP
60 70 80 90 100
LTIGAVSADH VFTDLFSRED EQDVGHIRLA READLIVVAP ATADLMAKMA
110 120 130 140 150
NGLADDLASA VLLARKVPLL IAPAMNPAMW DNPATRRNRL TLEKDGVRFI
160 170 180 190 200
GPEKGEMAES GEAGTGRMSE PLAIVAAIEN LLSPQAKPLA GKTIVMTSGP
210 220 230 240 250
TYEPIDPVRY IANRSSGKQG HAIAAALARL GATVHLVSGP VNIPDPEGVD
260 270 280 290 300
VIHVETAREM QAAVERHLPA DAAVMVAAVA DWRSANEAGQ KIKKKPGEGA
310 320 330 340 350
PVLAMVENPD ILAGIGHSKK RPGLVVGFAA ETQDVAENAR AKLEKKGADW
360 370 380 390 400
IVANDVSHGP GKDGVMGGDR NRVRILSHSG IEEWPEMSKE DVAERLAEKI

AASLLG
Length:406
Mass (Da):43,008
Last modified:May 10, 2005 - v1
Checksum:i8D47FCDEF86E50A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX76382.1.
RefSeqiWP_002965590.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX76382; AAX76382; BruAb2_1004.
GeneIDi29595321.
KEGGibmb:BruAb2_1004.

Similar proteinsi

Entry informationi

Entry nameiQ576Q2_BRUAB
AccessioniPrimary (citable) accession number: Q576Q2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported