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Q576P9

- UPP_BRUAB

UniProt

Q576P9 - UPP_BRUAB

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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei193 – 1931Uracil; via amide nitrogenUniRule annotation
Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-3227-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:BruAb2_1007
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Uracil phosphoribosyltransferasePRO_1000053681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_1007.

Structurei

3D structure databases

ProteinModelPortaliQ576P9.
SMRiQ576P9. Positions 2-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
Regioni198 – 2003Uracil bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiNIRIICV.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q576P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVTVVSHPL VKHKLTIMRK KETSTASFRR LLKEISLLLC YEVTRNLELT
60 70 80 90 100
TMSIETPLMP MEAPVLEGKK LVFASILRAG NGLLEGMLDL VPAARVAHIG
110 120 130 140 150
LYRDHDTLQP IEYYFKAPED IVNRLVIVVD PMLATANSAI AAIDKLKERG
160 170 180 190 200
ATNIRFLCLL AAPEGIERFT KAHPDVEVFT ASIDECLDEK GYIVPGLGDA

GDRMYGTK
Length:208
Mass (Da):22,994
Last modified:May 10, 2005 - v1
Checksum:i00C34084C66B701B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017224 Genomic DNA. Translation: AAX76385.1.
RefSeqiYP_223746.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX76385; AAX76385; BruAb2_1007.
GeneIDi3341682.
KEGGibmb:BruAb2_1007.
PATRICi17828331. VBIBruAbo15061_3333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017224 Genomic DNA. Translation: AAX76385.1 .
RefSeqi YP_223746.1. NC_006933.1.

3D structure databases

ProteinModelPortali Q576P9.
SMRi Q576P9. Positions 2-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb2_1007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX76385 ; AAX76385 ; BruAb2_1007 .
GeneIDi 3341682.
KEGGi bmb:BruAb2_1007.
PATRICi 17828331. VBIBruAbo15061_3333.

Phylogenomic databases

eggNOGi COG0035.
HOGENOMi HOG000262754.
KOi K00761.
OMAi NIRIICV.
OrthoDBi EOG6HF5WX.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00636 .
BioCyci BABO262698:GJC2-3227-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01218_B. Upp_B.
InterProi IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01091. upp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiUPP_BRUAB
AccessioniPrimary (citable) accession number: Q576P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3