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Q576P9

- UPP_BRUAB

UniProt

Q576P9 - UPP_BRUAB

Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei193 – 1931Uracil; via amide nitrogenUniRule annotation
    Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. UMP salvage Source: UniProtKB-UniPathway
    2. uracil salvage Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-3227-MONOMER.
    UniPathwayiUPA00574; UER00636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Alternative name(s):
    UMP pyrophosphorylaseUniRule annotation
    UPRTaseUniRule annotation
    Gene namesi
    Name:uppUniRule annotation
    Ordered Locus Names:BruAb2_1007
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Uracil phosphoribosyltransferasePRO_1000053681Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb2_1007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ576P9.
    SMRiQ576P9. Positions 2-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
    Regioni198 – 2003Uracil bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0035.
    HOGENOMiHOG000262754.
    KOiK00761.
    OMAiNIRIICV.
    OrthoDBiEOG6HF5WX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01218_B. Upp_B.
    InterProiIPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01091. upp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q576P9-1 [UniParc]FASTAAdd to Basket

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    MGVTVVSHPL VKHKLTIMRK KETSTASFRR LLKEISLLLC YEVTRNLELT    50
    TMSIETPLMP MEAPVLEGKK LVFASILRAG NGLLEGMLDL VPAARVAHIG 100
    LYRDHDTLQP IEYYFKAPED IVNRLVIVVD PMLATANSAI AAIDKLKERG 150
    ATNIRFLCLL AAPEGIERFT KAHPDVEVFT ASIDECLDEK GYIVPGLGDA 200
    GDRMYGTK 208
    Length:208
    Mass (Da):22,994
    Last modified:May 10, 2005 - v1
    Checksum:i00C34084C66B701B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX76385.1.
    RefSeqiYP_223746.1. NC_006933.1.

    Genome annotation databases

    EnsemblBacteriaiAAX76385; AAX76385; BruAb2_1007.
    GeneIDi3341682.
    KEGGibmb:BruAb2_1007.
    PATRICi17828331. VBIBruAbo15061_3333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017224 Genomic DNA. Translation: AAX76385.1 .
    RefSeqi YP_223746.1. NC_006933.1.

    3D structure databases

    ProteinModelPortali Q576P9.
    SMRi Q576P9. Positions 2-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb2_1007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX76385 ; AAX76385 ; BruAb2_1007 .
    GeneIDi 3341682.
    KEGGi bmb:BruAb2_1007.
    PATRICi 17828331. VBIBruAbo15061_3333.

    Phylogenomic databases

    eggNOGi COG0035.
    HOGENOMi HOG000262754.
    KOi K00761.
    OMAi NIRIICV.
    OrthoDBi EOG6HF5WX.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00636 .
    BioCyci BABO262698:GJC2-3227-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01218_B. Upp_B.
    InterProi IPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01091. upp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiUPP_BRUAB
    AccessioniPrimary (citable) accession number: Q576P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3