Q57675 (VATI_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase subunit I

Alternative name(s):
V-ATPase subunit I

Gene names

Name:	atpI
Ordered Locus Names:	MJ0222

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the V-ATPase 116 kDa subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting two-sector ATPase complex, proton-transporting domain Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 695	695	V-type ATP synthase subunit I		PRO_0000119229
Regions
	Transmembrane	392 – 412	21	Helical; Potential
	Transmembrane	425 – 445	21	Helical; Potential
	Transmembrane	497 – 517	21	Helical; Potential
	Transmembrane	534 – 554	21	Helical; Potential
	Transmembrane	556 – 576	21	Helical; Potential
	Transmembrane	605 – 625	21	Helical; Potential
	Transmembrane	627 – 647	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57675 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F03E5CEBEE29D53D	FASTA	695	76,954
	10 20 30 40 50 60 MILVRPVRMK KLKAVILDEK IDNVVRSLHE EGIVELCDLS EKLEDLEWKT LLSPSSSADY 70 80 90 100 110 120 VRNVTSLMIK AGRILDMFSS VSQKETSIKD ILNPKPVEKK KVSFNSYQEV IDYAEKVLNE 130 140 150 160 170 180 ISKEVDGPAE RLSELDNKKS KLLQLKEQIS YLKGLEFDLK YLGSGEYVFI GAGSVPKEKL 190 200 210 220 230 240 GELKAELDKV ADGYIGIFSG SEFEKDKKIR VPIVFVTLKE KLENVLSEIR KFEFERYDIS 250 260 270 280 290 300 DVEGTPSEAL SKIESELKAI ESERNSLIEK LKALAQKWEK ELLAVYELLS IEKARGDAYS 310 320 330 340 350 360 QFGKTDRTYY IEAWVPARDA EKAKSLIENS ADGFAFVEIT EPDEPEEKIP VLLDNPKVIK 370 380 390 400 410 420 PFEMLTEMYA LPKYNEVDPT LLLVPGFLLF YGIMLTDAVY GLLLTIIGLF IWKKIGKVSE 430 440 450 460 470 480 GANKLGYILT LAGISTVIMG IITGGYLGDF TYEFFGFDVT KTPLALVNPL GESYYINNNN 490 500 510 520 530 540 PLFTLGSISV TNGPMAILVF SIFVGLIHLL IGLFVGFKEN VKRGNMGDAF INQGVWILLI 550 560 570 580 590 600 LSIFVGIGLM FAGANTMIAG GIIGIFVVLA ILASMYKGYK SGGVMEAILG AMDVTGFLGN 610 620 630 640 650 660 VLSYARLLAL CLATGGLAMA VNIMAKLVGE SIPVIGIIVA IIILLVGHTF NFVMNGLGAF 670 680 690 IHSLRLHYVE FFSQFYEGGG KKFSPFKANR EYTTA

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98208.1.
PIR	G64327.
RefSeq	NP_247191.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q57675.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451072.
GenomeReviews	Gene locus MJ0222 in contig L77117_GR.
KEGG	mja:MJ_0222.
NMPDR	fig|243232.1.peg.228.
TIGR	MJ0222.
Phylogenomic databases
HOGENOM	HBG539023.
OMA	HEEGIVE.
ProtClustDB	PRK05771.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0222-MONOMER.
Family and domain databases
InterPro	IPR002490. ATPase_V0/A0-cplx_116kDa_su. [Graphical view]
KO	K02123.
PANTHER	PTHR11629. ATPase_V0/A0_116. 1 hit.
Pfam	PF01496. V_ATPase_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATI_METJA

Accession

Primary (citable) accession number: Q57675

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program