Q57670 (VATA_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase alpha chain
EC=3.6.3.14

Alternative name(s):
V-ATPase subunit A

Gene names

Name:	atpA
Ordered Locus Names:	MJ0217

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP MF_00309
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_00309
Sequence similarities	Belongs to the ATPase alpha/beta chains family.
Sequence caution	The sequence AAB98200.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	proton-transporting two-sector ATPase complex, catalytic domain Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 587	587	V-type ATP synthase alpha chain HAMAP MF_00309		PRO_0000144599
Regions
	Nucleotide binding	234 – 241	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57670 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: 26BDD64E6D7FEEC5	FASTA	587	65,557
	10 20 30 40 50 60 MPVVGKIIKI AGPVVVAEGM KGAQMYEVVK VGEEKLTGEI IQLHDDKAVI QVYEETSGIK 70 80 90 100 110 120 PGEPVVGTGA PLSVELGPGM LRAMYDGIQR PLTAIEEKTG SIFIPRGVDV PALPRDIKWE 130 140 150 160 170 180 FKPVVNEGDY VEEGDIIGTV DETPSIVHKI LVPIGVKGKI VEIKEGKFTV EETVAVVETE 190 200 210 220 230 240 NGERKEITMM QKWPVRKPRP YKEKLPPEIP LITGQRVEDT FFTLAKGGTA AIPGPFGSGK 250 260 270 280 290 300 TVTQHQLAKW SDADVVVYIG CGERGNEMTE VIEEFPHLED IRTGNKLMDR TVLIANTSNM 310 320 330 340 350 360 PVAAREASVY TGITIAEYFR DMGYGVLLTA DSTSRWAEAM REISGRLEEM PGEEGYPAYL 370 380 390 400 410 420 ASRLAQFYER AGRVITLGKD NRQGFVCIVG AVSPPGGDFS EPVTSNTLRI VKVFWALDAN 430 440 450 460 470 480 LARRRHFPAI NWLQSYSLYI DDVTEWWNTN TGPDWRQLRD EAMSLLQKEA ELQEIVQLVG 490 500 510 520 530 540 PDALPDRERV ILEVARMLRE DFLQQDAFDE VDTYCPPMKQ YLMLKIIMTF YQEALKAVER 550 560 570 580 GVEPAKILGV SVKQDIARMK YIPHDEFINV KSKEIMEKIK NELGSLN

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98200.1. Different initiation.
PIR	B64327.
RefSeq	NP_247186.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q57670.
SMR	Q57670. Positions 60-561.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451067.
GenomeReviews	Gene locus MJ0217 in contig L77117_GR.
KEGG	mja:MJ_0217.
NMPDR	fig|243232.1.peg.223.
TIGR	MJ0217.
Phylogenomic databases
HOGENOM	HBG288114.
OMA	SENKITW.
ProtClustDB	PRK04192.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0217-MONOMER.
Family and domain databases
HAMAP	MF_00309. ATP_synth_A_arch. [Tree]
InterPro	IPR020003. ATPase_a/bsu_AS. IPR005726. ATPase_A1-cplx_asu. IPR003593. ATPase_AAA+_core. IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR024034. ATPase_F1_bsu/V1_C. IPR022878. V-ATPase_su_A/alpha. [Graphical view]
Gene3D	G3DSA:1.10.1140.10. G3DSA:1.10.1140.10. 1 hit.
KO	K02117.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF47917. ATPase_a/b_C. 1 hit. SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMs	TIGR01043. ATP_syn_A_arch. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATA_METJA

Accession

Primary (citable) accession number: Q57670

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 24, 2001
Last modified:	November 16, 2011
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program