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Protein

Putative UDP-glucose 4-epimerase

Gene

MJ0211

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).By similarity

Catalytic activityi

UDP-alpha-D-glucose = UDP-alpha-D-galactose.

Cofactori

NAD+By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115SubstrateBy similarity1
Active sitei140Proton acceptorBy similarity1
Binding sitei140NADBy similarity1
Binding sitei140SubstrateBy similarity1
Binding sitei144NADBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei207SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 11NADBy similarity2
Nucleotide bindingi30 – 35NADBy similarity6
Nucleotide bindingi50 – 51NADBy similarity2
Nucleotide bindingi71 – 75NADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucose 4-epimerase (EC:5.1.3.2)
Alternative name(s):
Galactowaldenase
UDP-galactose 4-epimerase
Gene namesi
Ordered Locus Names:MJ0211
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832251 – 305Putative UDP-glucose 4-epimeraseAdd BLAST305

Proteomic databases

PRIDEiQ57664.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0211.

Structurei

3D structure databases

ProteinModelPortaliQ57664.
SMRiQ57664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 184Substrate bindingBy similarity2
Regioni198 – 200Substrate bindingBy similarity3
Regioni263 – 266Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01369. Archaea.
COG0451. LUCA.
InParanoidiQ57664.
KOiK01784.
OMAiHIAGYKY.
OrthoDBiPOG093Z08SP.
PhylomeDBiQ57664.

Family and domain databases

InterProiView protein in InterPro
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF01370. Epimerase. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVTGGAGF IGSHIVDKLI ENNYDVIILD NLTTGNKNNI NPKAEFVNAD
60 70 80 90 100
IRDKDLDEKI NFKDVEVVIH QAAQINVRNS VENPVYDGDI NVLGTINILE
110 120 130 140 150
MMRKYDIDKI VFASSGGAVY GEPNYLPVDE NHPINPLSPY GLSKYVGEEY
160 170 180 190 200
IKLYNRLYGI EYAILRYSNV YGERQDPKGE AGVISIFIDK MLKNQSPIIF
210 220 230 240 250
GDGNQTRDFV YVGDVAKANL MALNWKNEIV NIGTGKETSV NELFDIIKHE
260 270 280 290 300
IGFRGEAIYD KPREGEVYRI YLDIKKAESL GWKPEIDLKE GIKRVVNWMK

NNNRT
Length:305
Mass (Da):34,542
Last modified:November 1, 1996 - v1
Checksum:i2756773CF95D50BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98196.1.
PIRiD64326.
RefSeqiWP_010869707.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98196; AAB98196; MJ_0211.
GeneIDi1451061.
KEGGimja:MJ_0211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98196.1.
PIRiD64326.
RefSeqiWP_010869707.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ57664.
SMRiQ57664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0211.

Proteomic databases

PRIDEiQ57664.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98196; AAB98196; MJ_0211.
GeneIDi1451061.
KEGGimja:MJ_0211.

Phylogenomic databases

eggNOGiarCOG01369. Archaea.
COG0451. LUCA.
InParanoidiQ57664.
KOiK01784.
OMAiHIAGYKY.
OrthoDBiPOG093Z08SP.
PhylomeDBiQ57664.

Enzyme and pathway databases

UniPathwayiUPA00214.

Family and domain databases

InterProiView protein in InterPro
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF01370. Epimerase. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGALE_METJA
AccessioniPrimary (citable) accession number: Q57664
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.