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Q57656

- PUR5_METJA

UniProt

Q57656 - PUR5_METJA

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:MJ0203
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0203.

Structurei

3D structure databases

ProteinModelPortaliQ57656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.Curated

Phylogenomic databases

eggNOGiCOG0150.
InParanoidiQ57656.
KOiK01933.
OMAiVIGKIEH.
PhylomeDBiQ57656.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57656-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTYKDAGVD ISHEDKVIKA LVSQITFKRS DIKPAELGLH YAGAVEFGDY
60 70 80 90 100
YLVLSTDGVG SKMIVAEMAN KFDTVGIDMI AMNVNDAICI GAEPIALVDY
110 120 130 140 150
LAVGHITEEI AEQIGKGLNE GAKEANINIV GGETATLPDM IKGIDLAGTV
160 170 180 190 200
LAIVKKDEII TGKDVKAGDV IVGLRSSGIH SNGLSLARKV FFDIAKLDIN
210 220 230 240 250
DKLSYGKTVA EELLTPTRIY VKPVLEMIRD KDIEVKGLAH ITGGSFRKLK
260 270 280 290 300
RLNDKVTYYI DNLPEPLPIF KEIQRLGNVP DEEMFRTFNM GIGFCVIVDE
310 320 330 340 350
EDANKVIKIA NKYNIPAQVI GRVVDSLEVN GNKIVGKAVV KYNDKHIILE
Length:350
Mass (Da):38,202
Last modified:November 1, 1996 - v1
Checksum:iC1F68B7884DFB293
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98187.1.
PIRiD64325.
RefSeqiNP_247171.1. NC_000909.1.
WP_010869698.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98187; AAB98187; MJ_0203.
GeneIDi1451052.
KEGGimja:MJ_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98187.1 .
PIRi D64325.
RefSeqi NP_247171.1. NC_000909.1.
WP_010869698.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q57656.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98187 ; AAB98187 ; MJ_0203 .
GeneIDi 1451052.
KEGGi mja:MJ_0203.

Phylogenomic databases

eggNOGi COG0150.
InParanoidi Q57656.
KOi K01933.
OMAi VIGKIEH.
PhylomeDBi Q57656.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiPUR5_METJA
AccessioniPrimary (citable) accession number: Q57656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3