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Q57656 (PUR5_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:MJ0203
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741_A

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741_A

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741_A.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741_A
PRO_0000148281

Sequences

Sequence LengthMass (Da)Tools
Q57656 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C1F68B7884DFB293

FASTA35038,202
        10         20         30         40         50         60 
MVTYKDAGVD ISHEDKVIKA LVSQITFKRS DIKPAELGLH YAGAVEFGDY YLVLSTDGVG 

        70         80         90        100        110        120 
SKMIVAEMAN KFDTVGIDMI AMNVNDAICI GAEPIALVDY LAVGHITEEI AEQIGKGLNE 

       130        140        150        160        170        180 
GAKEANINIV GGETATLPDM IKGIDLAGTV LAIVKKDEII TGKDVKAGDV IVGLRSSGIH 

       190        200        210        220        230        240 
SNGLSLARKV FFDIAKLDIN DKLSYGKTVA EELLTPTRIY VKPVLEMIRD KDIEVKGLAH 

       250        260        270        280        290        300 
ITGGSFRKLK RLNDKVTYYI DNLPEPLPIF KEIQRLGNVP DEEMFRTFNM GIGFCVIVDE 

       310        320        330        340        350 
EDANKVIKIA NKYNIPAQVI GRVVDSLEVN GNKIVGKAVV KYNDKHIILE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98187.1.
PIRD64325.
RefSeqNP_247171.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ57656.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98187; AAB98187; MJ_0203.
GeneID1451052.
KEGGmja:MJ_0203.

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAVIGKIEH.
PhylomeDBQ57656.

Enzyme and pathway databases

UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_A. AIRS_A.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_METJA
AccessionPrimary (citable) accession number: Q57656
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names