Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q57645 (ARGJ_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate N-acetyltransferase
EC=2.3.1.35
Alternative name(s):
Ornithine acetyltransferase
Ornithine transacetylase
Short name=OATase

Cleaved into the following 2 chains:

  1. Glutamate N-acetyltransferase alpha chain
  2. Glutamate N-acetyltransferase beta chain
Gene names
Name:argJ
Ordered Locus Names:MJ0186
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate. HAMAP MF_01106

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1. HAMAP MF_01106

Subunit structure

Heterotetramer of two alpha and two beta chains By similarity.

Subcellular location

Cytoplasm Probable HAMAP MF_01106.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. HAMAP MF_01106

Sequence similarities

Belongs to the ArgJ family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   PTMAutocatalytic cleavage
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA:L-glutamate N-acetyltransferase activity

Inferred from electronic annotation. Source: InterPro

glutamate N-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184Glutamate N-acetyltransferase alpha chain By similarity
PRO_0000002273
Chain185 – 402218Glutamate N-acetyltransferase beta chain By similarity
PRO_0000002274

Sites

Site184 – 1852Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57645 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2D915AB01CC7A8D6

FASTA40243,757
        10         20         30         40         50         60 
MRVIDGGVTA PKGFKANGYK EGKFGVAIII SEKDAVGAGT FTTNKVVAHP VVLSRELIKN 

        70         80         90        100        110        120 
RDKFRAIVAN SGNANCFTKD GMEDAKEMQR LVAELFNINE DEVLVASTGV IGRKMDMNII 

       130        140        150        160        170        180 
KDRINKVYNL IKEGNSSINA AKAIMTTDTK PKEIAVEFEV NGKTVRVGGI AKGAGMIAPN 

       190        200        210        220        230        240 
MLHATMLCFI TTDIEIDKES LTNILQKVVD KTFNNISVDG DTSTNDTVFV LANGLSGVNY 

       250        260        270        280        290        300 
EECGEEFENA LLYVCRELAK MIVKDGEGAT KFMEVVVKGA KTEEDAVKAS KAIVNSLLVK 

       310        320        330        340        350        360 
TAVFGGDPNW GRIVAAVGYS GADFNPEVVD VILSNYKDEV YLVKDGIPLA DEGTEELKKA 

       370        380        390        400 
EEIMKSDEIK IVVDLKMGEF ENVCYGCDLS YEYVRINAEY TT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB98166.1.
PIRC64323.
RefSeqNP_247154.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ57645.
ModBaseSearch...

Protein family/group databases

MEROPST05.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1451033.
GenomeReviewsGene locus MJ0186 in contig L77117_GR.
KEGGmja:MJ_0186.
NMPDRfig|243232.1.peg.191.
TIGRMJ0186.

Phylogenomic databases

HOGENOMHBG284202.
OMAFPKLATR.
ProtClustDBPRK05388.

Enzyme and pathway databases

BioCycMJAN243232:MJ_0186-MONOMER.

Family and domain databases

HAMAPMF_01106. ArgJ.
[Tree]
InterProIPR002813. Arg_biosynth_ArgJ.
IPR016117. Pept_S58_DmpA/Arg_biosyn_ArgJ.
[Graphical view]
KOK00620.
PANTHERPTHR23100. ArgJ. 1 hit.
PfamPF01960. ArgJ. 1 hit.
[Graphical view]
ProDomPD004193. Arg_biosynth_ArgJ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56266. Pept_S58_DmpA/Arg_biosyn_ArgJ. 1 hit.
TIGRFAMsTIGR00120. ArgJ. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGJ_METJA
AccessionPrimary (citable) accession number: Q57645
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 16, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents