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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase (EC:2.1.1.77)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Short name:
PIMT
Gene namesi
Name:pcm
Ordered Locus Names:MJ0172
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Protein-L-isoaspartate O-methyltransferasePRO_0000111916Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0172.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1614Combined sources
Helixi23 – 319Combined sources
Helixi34 – 374Combined sources
Helixi40 – 456Combined sources
Beta strandi52 – 554Combined sources
Beta strandi58 – 603Combined sources
Helixi63 – 7210Combined sources
Beta strandi80 – 845Combined sources
Helixi90 – 9910Combined sources
Beta strandi103 – 1108Combined sources
Helixi112 – 12514Combined sources
Beta strandi130 – 1356Combined sources
Helixi137 – 1393Combined sources
Helixi142 – 1443Combined sources
Beta strandi147 – 15812Combined sources
Helixi161 – 1655Combined sources
Beta strandi167 – 19024Combined sources
Beta strandi193 – 20210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YXEX-ray2.00A/B1-215[»]
ProteinModelPortaliQ57636.
SMRiQ57636. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57636.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00976. Archaea.
COG2518. LUCA.
InParanoidiQ57636.
KOiK00573.
OMAiHNISTRH.
PhylomeDBiQ57636.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLEEQKKAV IEKLIREGYI KSKRVIDALL KVPREEFLPE HLKEYAYVDT
60 70 80 90 100
PLEIGYGQTI SAIHMVGMMC ELLDLKPGMK VLEIGTGCGY HAAVTAEIVG
110 120 130 140 150
EDGLVVSIER IPELAEKAER TLRKLGYDNV IVIVGDGTLG YEPLAPYDRI
160 170 180 190 200
YTTAAGPKIP EPLIRQLKDG GKLLMPVGRY LQRLVLAEKR GDEIIIKDCG
210
PVAFVPLVGK EGFQG
Length:215
Mass (Da):23,761
Last modified:November 1, 1996 - v1
Checksum:iE5A8634F2E2BAE8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98157.1.
PIRiE64321.

Genome annotation databases

EnsemblBacteriaiAAB98157; AAB98157; MJ_0172.
KEGGimja:MJ_0172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98157.1.
PIRiE64321.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YXEX-ray2.00A/B1-215[»]
ProteinModelPortaliQ57636.
SMRiQ57636. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98157; AAB98157; MJ_0172.
KEGGimja:MJ_0172.

Phylogenomic databases

eggNOGiarCOG00976. Archaea.
COG2518. LUCA.
InParanoidiQ57636.
KOiK00573.
OMAiHNISTRH.
PhylomeDBiQ57636.

Miscellaneous databases

EvolutionaryTraceiQ57636.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiPIMT_METJA
AccessioniPrimary (citable) accession number: Q57636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.