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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase (EC:2.1.1.77)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Short name:
PIMT
Gene namesi
Name:pcm
Ordered Locus Names:MJ0172
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001119161 – 215Protein-L-isoaspartate O-methyltransferaseAdd BLAST215

Proteomic databases

PRIDEiQ57636.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0172.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 16Combined sources14
Helixi23 – 31Combined sources9
Helixi34 – 37Combined sources4
Helixi40 – 45Combined sources6
Beta strandi52 – 55Combined sources4
Beta strandi58 – 60Combined sources3
Helixi63 – 72Combined sources10
Beta strandi80 – 84Combined sources5
Helixi90 – 99Combined sources10
Beta strandi103 – 110Combined sources8
Helixi112 – 125Combined sources14
Beta strandi130 – 135Combined sources6
Helixi137 – 139Combined sources3
Helixi142 – 144Combined sources3
Beta strandi147 – 158Combined sources12
Helixi161 – 165Combined sources5
Beta strandi167 – 190Combined sources24
Beta strandi193 – 202Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YXEX-ray2.00A/B1-215[»]
ProteinModelPortaliQ57636.
SMRiQ57636.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57636.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00976. Archaea.
COG2518. LUCA.
InParanoidiQ57636.
KOiK00573.
OMAiPYTVAFQ.
PhylomeDBiQ57636.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLEEQKKAV IEKLIREGYI KSKRVIDALL KVPREEFLPE HLKEYAYVDT
60 70 80 90 100
PLEIGYGQTI SAIHMVGMMC ELLDLKPGMK VLEIGTGCGY HAAVTAEIVG
110 120 130 140 150
EDGLVVSIER IPELAEKAER TLRKLGYDNV IVIVGDGTLG YEPLAPYDRI
160 170 180 190 200
YTTAAGPKIP EPLIRQLKDG GKLLMPVGRY LQRLVLAEKR GDEIIIKDCG
210
PVAFVPLVGK EGFQG
Length:215
Mass (Da):23,761
Last modified:November 1, 1996 - v1
Checksum:iE5A8634F2E2BAE8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98157.1.
PIRiE64321.
RefSeqiWP_010869667.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98157; AAB98157; MJ_0172.
GeneIDi1451019.
KEGGimja:MJ_0172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98157.1.
PIRiE64321.
RefSeqiWP_010869667.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YXEX-ray2.00A/B1-215[»]
ProteinModelPortaliQ57636.
SMRiQ57636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0172.

Proteomic databases

PRIDEiQ57636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98157; AAB98157; MJ_0172.
GeneIDi1451019.
KEGGimja:MJ_0172.

Phylogenomic databases

eggNOGiarCOG00976. Archaea.
COG2518. LUCA.
InParanoidiQ57636.
KOiK00573.
OMAiPYTVAFQ.
PhylomeDBiQ57636.

Miscellaneous databases

EvolutionaryTraceiQ57636.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIMT_METJA
AccessioniPrimary (citable) accession number: Q57636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.