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Q57635 (DNLI_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:MJ0171
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573DNA ligase HAMAP-Rule MF_00407
PRO_0000059604

Sites

Active site2501N6-AMP-lysine intermediate By similarity
Binding site2481ATP By similarity
Binding site2551ATP By similarity
Binding site2701ATP By similarity
Binding site2991ATP By similarity
Binding site3401ATP By similarity
Binding site4321ATP By similarity
Binding site4381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57635 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6F95434EE968038C

FASTA57366,790
        10         20         30         40         50         60 
MLWRDVCEIF NKIEKTTKRL EKRDYFIKLI DMVKEKGKPE DLKKICYMAI GRVYPEYDER 

        70         80         90        100        110        120 
ELGIGEKLLI NAVTSIGIKK DELLEKIKET GDIGLAIEQL KSKIKQASLF FQPLTVDEVY 

       130        140        150        160        170        180 
ETLKRVGEIE GEGSQKKKLR LISSLFLRAS PIECRYLARL ILEDMRIGMN VPTILDALSV 

       190        200        210        220        230        240 
YFNVPKEKLE KIYAITNDIG LLAEKLLMGD LESEELKLKL FRPIKPMLAQ LTPSIEEALL 

       250        260        270        280        290        300 
EMGRAQFETK YDGARVQIHK DGNKVKIYSR RLEDVTNALP EIVEAVKNIN VDKLIVEGEC 

       310        320        330        340        350        360 
VAIDKQTGKP RPFQDILRRF RRKYDIGKMM KEINLRVYLF DILYKDGVSF IDEEFEKRRK 

       370        380        390        400        410        420 
VLEEIVGYEN DWRTERKRIE KELKSDKIID ISYKLVTNDA KEAREFYNWS LSIGHEGVMI 

       430        440        450        460        470        480 
KNLKAPYTPG SRVRTMYKFK PTLESLDVVI TKAKRGMGKR KDWYGSFEIC VRDEEGNLYP 

       490        500        510        520        530        540 
IGHVGTGLTE ADLEFLKEEI DKIIIRDLGE EVEVEPKIVI EVAYEEIQKS DKYPCGYALR 

       550        560        570 
FPRVVRFRFD KGVNEINTIE DVERIYEIQR GRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98156.1.
PIRD64321.
RefSeqNP_247139.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ57635.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0171.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98156; AAB98156; MJ_0171.
GeneID1451018.
KEGGmja:MJ_0171.

Phylogenomic databases

eggNOGCOG1793.
KOK10747.
OMAGRPRPFQ.
ProtClustDBCLSK876100.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_METJA
AccessionPrimary (citable) accession number: Q57635
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names