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Q57635

- DNLI_METJA

UniProt

Q57635 - DNLI_METJA

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Protein

DNA ligase

Gene

lig

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATPBy similarity
Active sitei250 – 2501N6-AMP-lysine intermediateBy similarity
Binding sitei255 – 2551ATPBy similarity
Binding sitei270 – 2701ATPBy similarity
Binding sitei299 – 2991ATPBy similarity
Binding sitei340 – 3401ATPBy similarity
Binding sitei432 – 4321ATPBy similarity
Binding sitei438 – 4381ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:MJ0171
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573DNA ligasePRO_0000059604Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0171.

Structurei

3D structure databases

ProteinModelPortaliQ57635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiQ57635.
KOiK10747.
OMAiARVQVHK.
PhylomeDBiQ57635.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57635-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWRDVCEIF NKIEKTTKRL EKRDYFIKLI DMVKEKGKPE DLKKICYMAI
60 70 80 90 100
GRVYPEYDER ELGIGEKLLI NAVTSIGIKK DELLEKIKET GDIGLAIEQL
110 120 130 140 150
KSKIKQASLF FQPLTVDEVY ETLKRVGEIE GEGSQKKKLR LISSLFLRAS
160 170 180 190 200
PIECRYLARL ILEDMRIGMN VPTILDALSV YFNVPKEKLE KIYAITNDIG
210 220 230 240 250
LLAEKLLMGD LESEELKLKL FRPIKPMLAQ LTPSIEEALL EMGRAQFETK
260 270 280 290 300
YDGARVQIHK DGNKVKIYSR RLEDVTNALP EIVEAVKNIN VDKLIVEGEC
310 320 330 340 350
VAIDKQTGKP RPFQDILRRF RRKYDIGKMM KEINLRVYLF DILYKDGVSF
360 370 380 390 400
IDEEFEKRRK VLEEIVGYEN DWRTERKRIE KELKSDKIID ISYKLVTNDA
410 420 430 440 450
KEAREFYNWS LSIGHEGVMI KNLKAPYTPG SRVRTMYKFK PTLESLDVVI
460 470 480 490 500
TKAKRGMGKR KDWYGSFEIC VRDEEGNLYP IGHVGTGLTE ADLEFLKEEI
510 520 530 540 550
DKIIIRDLGE EVEVEPKIVI EVAYEEIQKS DKYPCGYALR FPRVVRFRFD
560 570
KGVNEINTIE DVERIYEIQR GRK
Length:573
Mass (Da):66,790
Last modified:November 1, 1996 - v1
Checksum:i6F95434EE968038C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98156.1.
PIRiD64321.
RefSeqiNP_247139.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98156; AAB98156; MJ_0171.
GeneIDi1451018.
KEGGimja:MJ_0171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98156.1 .
PIRi D64321.
RefSeqi NP_247139.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q57635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98156 ; AAB98156 ; MJ_0171 .
GeneIDi 1451018.
KEGGi mja:MJ_0171.

Phylogenomic databases

eggNOGi COG1793.
InParanoidi Q57635.
KOi K10747.
OMAi ARVQVHK.
PhylomeDBi Q57635.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiDNLI_METJA
AccessioniPrimary (citable) accession number: Q57635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3