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Q57634

- MSMJS_METJA

UniProt

Q57634 - MSMJS_METJA

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Protein
Small-conductance mechanosensitive channel MscMJ
Gene
MJ0170
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Small-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Exhibits a sixfold preference for cations over anions. Non-rectifying.1 Publication

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
  2. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.23.4.2. the small conductance mechanosensitive ion channel (mscs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Small-conductance mechanosensitive channel MscMJ
Gene namesi
Ordered Locus Names:MJ0170
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Reviewed prediction
Add
BLAST
Transmembranei130 – 15021Helical; Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Small-conductance mechanosensitive channel MscMJ
PRO_0000110253Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0170.

Structurei

3D structure databases

ProteinModelPortaliQ57634.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0668.
KOiK16052.
OMAiDLRVEYF.
PhylomeDBiQ57634.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR006686. MscS_channel_CS.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57634-1 [UniParc]FASTAAdd to Basket

« Hide

MNMEIFGNSI SNILIFVVIT LLGIFIGKIV DKIVRNYLKK IIDKTKTKFD    50
DIILESIDLP IIVLVVTLFF YFGLRFLILP DYILKLIDEA VKVVVILSAT 100
YFAVKFIDGI FEHYLIPLTE KTETELDEHI IKPLKKVVKI LTILLGILTA 150
LSSVGYDITA LLAGLGVGGL ALALAMQDTI KNFIAGILIL IDKPFSLGHW 200
VKVKGAEGIV EEIGIRSTRI RTFDYTLITI PNSELLDSAI ENLTVRDRRR 250
VLMTIGLTYN TPVEKIKRAK EIIKEIVENH PATLPPYRVH FREYGDWSLN 300
LRVEYFVRNM GFDYYLNAVD EINLKIKEEF EKEGIEMAFP TYTVYLEKDN 350
Length:350
Mass (Da):39,953
Last modified:November 1, 1996 - v1
Checksum:i4EA0E5025086E7DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98155.1.
PIRiC64321.
RefSeqiNP_247138.1. NC_000909.1.
WP_010869665.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98155; AAB98155; MJ_0170.
GeneIDi1451017.
KEGGimja:MJ_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98155.1 .
PIRi C64321.
RefSeqi NP_247138.1. NC_000909.1.
WP_010869665.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q57634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0170.

Protein family/group databases

TCDBi 1.A.23.4.2. the small conductance mechanosensitive ion channel (mscs) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98155 ; AAB98155 ; MJ_0170 .
GeneIDi 1451017.
KEGGi mja:MJ_0170.

Phylogenomic databases

eggNOGi COG0668.
KOi K16052.
OMAi DLRVEYF.
PhylomeDBi Q57634.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR006686. MscS_channel_CS.
IPR011014. MscS_channel_TM-2.
[Graphical view ]
Pfami PF00924. MS_channel. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEi PS01246. UPF0003. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Molecular identification of a mechanosensitive channel in archaea."
    Kloda A., Martinac B.
    Biophys. J. 80:229-240(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A MECHANOSENSITIVE CHANNEL, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMSMJS_METJA
AccessioniPrimary (citable) accession number: Q57634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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