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Protein

Small-conductance mechanosensitive channel MscMJ

Gene

MJ0170

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Small-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Exhibits a sixfold preference for cations over anions. Non-rectifying.1 Publication

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
  2. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.23.4.2. the small conductance mechanosensitive ion channel (mscs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Small-conductance mechanosensitive channel MscMJ
Gene namesi
Ordered Locus Names:MJ0170
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

Subcellular locationi

  1. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Small-conductance mechanosensitive channel MscMJPRO_0000110253Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0170.

Structurei

3D structure databases

ProteinModelPortaliQ57634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0668.
InParanoidiQ57634.
KOiK16052.
OMAiDLRVEYF.
PhylomeDBiQ57634.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR006686. MscS_channel_CS.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMEIFGNSI SNILIFVVIT LLGIFIGKIV DKIVRNYLKK IIDKTKTKFD
60 70 80 90 100
DIILESIDLP IIVLVVTLFF YFGLRFLILP DYILKLIDEA VKVVVILSAT
110 120 130 140 150
YFAVKFIDGI FEHYLIPLTE KTETELDEHI IKPLKKVVKI LTILLGILTA
160 170 180 190 200
LSSVGYDITA LLAGLGVGGL ALALAMQDTI KNFIAGILIL IDKPFSLGHW
210 220 230 240 250
VKVKGAEGIV EEIGIRSTRI RTFDYTLITI PNSELLDSAI ENLTVRDRRR
260 270 280 290 300
VLMTIGLTYN TPVEKIKRAK EIIKEIVENH PATLPPYRVH FREYGDWSLN
310 320 330 340 350
LRVEYFVRNM GFDYYLNAVD EINLKIKEEF EKEGIEMAFP TYTVYLEKDN
Length:350
Mass (Da):39,953
Last modified:November 1, 1996 - v1
Checksum:i4EA0E5025086E7DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98155.1.
PIRiC64321.
RefSeqiNP_247138.1. NC_000909.1.
WP_010869665.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98155; AAB98155; MJ_0170.
GeneIDi1451017.
KEGGimja:MJ_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98155.1.
PIRiC64321.
RefSeqiNP_247138.1. NC_000909.1.
WP_010869665.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ57634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ0170.

Protein family/group databases

TCDBi1.A.23.4.2. the small conductance mechanosensitive ion channel (mscs) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98155; AAB98155; MJ_0170.
GeneIDi1451017.
KEGGimja:MJ_0170.

Phylogenomic databases

eggNOGiCOG0668.
InParanoidiQ57634.
KOiK16052.
OMAiDLRVEYF.
PhylomeDBiQ57634.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR006686. MscS_channel_CS.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Molecular identification of a mechanosensitive channel in archaea."
    Kloda A., Martinac B.
    Biophys. J. 80:229-240(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A MECHANOSENSITIVE CHANNEL, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMSMJS_METJA
AccessioniPrimary (citable) accession number: Q57634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.