Q57634 (MSMJS_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small-conductance mechanosensitive channel MscMJ

Gene names

Ordered Locus Names:

MJ0170

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Small-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Exhibits a sixfold preference for cations over anions. Non-rectifying. Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.2.
Sequence similarities	Belongs to the MscS (TC 1.A.23) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Small-conductance mechanosensitive channel MscMJ		PRO_0000110253
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57634 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4EA0E5025086E7DF	FASTA	350	39,953
	10 20 30 40 50 60 MNMEIFGNSI SNILIFVVIT LLGIFIGKIV DKIVRNYLKK IIDKTKTKFD DIILESIDLP 70 80 90 100 110 120 IIVLVVTLFF YFGLRFLILP DYILKLIDEA VKVVVILSAT YFAVKFIDGI FEHYLIPLTE 130 140 150 160 170 180 KTETELDEHI IKPLKKVVKI LTILLGILTA LSSVGYDITA LLAGLGVGGL ALALAMQDTI 190 200 210 220 230 240 KNFIAGILIL IDKPFSLGHW VKVKGAEGIV EEIGIRSTRI RTFDYTLITI PNSELLDSAI 250 260 270 280 290 300 ENLTVRDRRR VLMTIGLTYN TPVEKIKRAK EIIKEIVENH PATLPPYRVH FREYGDWSLN 310 320 330 340 350 LRVEYFVRNM GFDYYLNAVD EINLKIKEEF EKEGIEMAFP TYTVYLEKDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Molecular identification of a mechanosensitive channel in archaea." Kloda A., Martinac B. Biophys. J. 80:229-240(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A MECHANOSENSITIVE CHANNEL, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98155.1.
PIR	C64321.
RefSeq	NP_247138.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q57634.
ModBase	Search...
Protein-protein interaction databases
STRING	243232.MJ0170.
Protein family/group databases
TCDB	1.A.23.4.2. small conductance mechanosensitive ion channel (MscS) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB98155; AAB98155; MJ_0170.
GeneID	1451017.
KEGG	mja:MJ_0170.
Phylogenomic databases
eggNOG	COG0668.
KO	K16052.
OMA	DLRVEYF.
ProtClustDB	CLSK876099.
Family and domain databases
InterPro	IPR010920. LSM_dom. IPR011066. MscC_channel_C. IPR006685. MscS_channel. IPR006686. MscS_channel_CS. IPR011014. MscS_channel_TM-2. [Graphical view]
Pfam	PF00924. MS_channel. 1 hit. [Graphical view]
SUPFAM	SSF82689. MscC_channel_C. 1 hit. SSF82861. MscS_transmembr. 1 hit. SSF50182. Sm_like_riboprot. 1 hit.
PROSITE	PS01246. UPF0003. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSMJS_METJA

Accession

Primary (citable) accession number: Q57634

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program