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Protein

Small-conductance mechanosensitive channel MscMJ

Gene

MJ0170

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Exhibits a sixfold preference for cations over anions. Non-rectifying.1 Publication

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.23.4.2 the small conductance mechanosensitive ion channel (mscs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Small-conductance mechanosensitive channel MscMJ
Gene namesi
Ordered Locus Names:MJ0170
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001102531 – 350Small-conductance mechanosensitive channel MscMJAdd BLAST350

Proteomic databases

PRIDEiQ57634

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0170

Structurei

3D structure databases

ProteinModelPortaliQ57634
SMRiQ57634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01568 Archaea
COG0668 LUCA
InParanoidiQ57634
KOiK16052
OMAiIGDWIEW
OrthoDBiPOG093Z09UI
PhylomeDBiQ57634

Family and domain databases

Gene3Di2.30.30.60, 1 hit
InterProiView protein in InterPro
IPR010920 LSM_dom_sf
IPR011066 MscC_channel_C
IPR006685 MscS_channel
IPR006686 MscS_channel_CS
IPR011014 MscS_channel_TM-2
IPR023408 MscS_dom_sf
PfamiView protein in Pfam
PF00924 MS_channel, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
SSF82689 SSF82689, 1 hit
SSF82861 SSF82861, 1 hit
PROSITEiView protein in PROSITE
PS01246 UPF0003, 1 hit

Sequencei

Sequence statusi: Complete.

Q57634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMEIFGNSI SNILIFVVIT LLGIFIGKIV DKIVRNYLKK IIDKTKTKFD
60 70 80 90 100
DIILESIDLP IIVLVVTLFF YFGLRFLILP DYILKLIDEA VKVVVILSAT
110 120 130 140 150
YFAVKFIDGI FEHYLIPLTE KTETELDEHI IKPLKKVVKI LTILLGILTA
160 170 180 190 200
LSSVGYDITA LLAGLGVGGL ALALAMQDTI KNFIAGILIL IDKPFSLGHW
210 220 230 240 250
VKVKGAEGIV EEIGIRSTRI RTFDYTLITI PNSELLDSAI ENLTVRDRRR
260 270 280 290 300
VLMTIGLTYN TPVEKIKRAK EIIKEIVENH PATLPPYRVH FREYGDWSLN
310 320 330 340 350
LRVEYFVRNM GFDYYLNAVD EINLKIKEEF EKEGIEMAFP TYTVYLEKDN
Length:350
Mass (Da):39,953
Last modified:November 1, 1996 - v1
Checksum:i4EA0E5025086E7DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98155.1
PIRiC64321

Genome annotation databases

EnsemblBacteriaiAAB98155; AAB98155; MJ_0170
KEGGimja:MJ_0170

Entry informationi

Entry nameiMSMJS_METJA
AccessioniPrimary (citable) accession number: Q57634
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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