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Q57634

- MSMJS_METJA

UniProt

Q57634 - MSMJS_METJA

Protein

Small-conductance mechanosensitive channel MscMJ

Gene

MJ0170

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Small-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Exhibits a sixfold preference for cations over anions. Non-rectifying.1 Publication

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW
    2. transmembrane transport Source: InterPro

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi1.A.23.4.2. the small conductance mechanosensitive ion channel (mscs) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small-conductance mechanosensitive channel MscMJ
    Gene namesi
    Ordered Locus Names:MJ0170
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Small-conductance mechanosensitive channel MscMJPRO_0000110253Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0170.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57634.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0668.
    KOiK16052.
    OMAiDLRVEYF.
    PhylomeDBiQ57634.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR011066. MscC_channel_C.
    IPR006685. MscS_channel.
    IPR006686. MscS_channel_CS.
    IPR011014. MscS_channel_TM-2.
    [Graphical view]
    PfamiPF00924. MS_channel. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.
    SSF82689. SSF82689. 1 hit.
    SSF82861. SSF82861. 1 hit.
    PROSITEiPS01246. UPF0003. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57634-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNMEIFGNSI SNILIFVVIT LLGIFIGKIV DKIVRNYLKK IIDKTKTKFD    50
    DIILESIDLP IIVLVVTLFF YFGLRFLILP DYILKLIDEA VKVVVILSAT 100
    YFAVKFIDGI FEHYLIPLTE KTETELDEHI IKPLKKVVKI LTILLGILTA 150
    LSSVGYDITA LLAGLGVGGL ALALAMQDTI KNFIAGILIL IDKPFSLGHW 200
    VKVKGAEGIV EEIGIRSTRI RTFDYTLITI PNSELLDSAI ENLTVRDRRR 250
    VLMTIGLTYN TPVEKIKRAK EIIKEIVENH PATLPPYRVH FREYGDWSLN 300
    LRVEYFVRNM GFDYYLNAVD EINLKIKEEF EKEGIEMAFP TYTVYLEKDN 350
    Length:350
    Mass (Da):39,953
    Last modified:November 1, 1996 - v1
    Checksum:i4EA0E5025086E7DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98155.1.
    PIRiC64321.
    RefSeqiNP_247138.1. NC_000909.1.
    WP_010869665.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98155; AAB98155; MJ_0170.
    GeneIDi1451017.
    KEGGimja:MJ_0170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98155.1 .
    PIRi C64321.
    RefSeqi NP_247138.1. NC_000909.1.
    WP_010869665.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q57634.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0170.

    Protein family/group databases

    TCDBi 1.A.23.4.2. the small conductance mechanosensitive ion channel (mscs) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98155 ; AAB98155 ; MJ_0170 .
    GeneIDi 1451017.
    KEGGi mja:MJ_0170.

    Phylogenomic databases

    eggNOGi COG0668.
    KOi K16052.
    OMAi DLRVEYF.
    PhylomeDBi Q57634.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR011066. MscC_channel_C.
    IPR006685. MscS_channel.
    IPR006686. MscS_channel_CS.
    IPR011014. MscS_channel_TM-2.
    [Graphical view ]
    Pfami PF00924. MS_channel. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    SSF82689. SSF82689. 1 hit.
    SSF82861. SSF82861. 1 hit.
    PROSITEi PS01246. UPF0003. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. "Molecular identification of a mechanosensitive channel in archaea."
      Kloda A., Martinac B.
      Biophys. J. 80:229-240(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A MECHANOSENSITIVE CHANNEL, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMSMJS_METJA
    AccessioniPrimary (citable) accession number: Q57634
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3