Q57620 (ACDB2_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-CoA decarbonylase/synthase complex subunit beta 2
Short name=ACDS complex subunit beta 2
EC=2.3.1.-

Alternative name(s):
ACDS complex acyltransferase 2

Gene names

Name:	cdhC2
Ordered Locus Names:	MJ0156

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO2 By similarity. HAMAP MF_01138
Catalytic activity	Acetyl-CoA + [acetyl-CoA decarbonylase/synthase complex beta subunit] = CoA + acetyl-[acetyl-CoA decarbonylase/synthase complex beta subunit]. HAMAP MF_01138
Cofactor	Binds 1 nickel-iron-sulfur cluster By similarity. HAMAP MF_01138
Subunit structure	Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha2epsilon2)(4)-beta(8)-(gamma1delta1)8 Potential.
Sequence similarities	Belongs to the CdhC family.

Ontologies

Keywords
Ligand	Iron Iron-sulfur Metal-binding Nickel
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbon-monoxide dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: InterPro iron-sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Acetyl-CoA decarbonylase/synthase complex subunit beta 2 HAMAP MF_01138		PRO_0000155102
Regions
	Compositional bias	401 – 420	20	Glu-rich HAMAP MF_01138
Sites
	Metal binding	187	1	Nickel-iron-sulfur Potential
	Metal binding	190	1	Nickel-iron-sulfur Potential
	Metal binding	276	1	Nickel-iron-sulfur Potential
	Metal binding	278	1	Nickel-iron-sulfur Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57620 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BDC866AD7C28661C	FASTA	469	52,642
	10 20 30 40 50 60 MFDDIPVSVG PMNEGERVRG PDMYVELAGP KSYGFELVKV VNKAEDKVEI IGKDIDEMEE 70 80 90 100 110 120 GSRNPFAIIV EVSGSNLEED LEGVLERRIH EFLNYIEGVM HLNQRDQVWI RINKDSFNKG 130 140 150 160 170 180 LRLKHIGKVV QRLFKAEFPF IEKCDVTIIT DPEKVKEELE KAREIYNKRD EKTKALHEED 190 200 210 220 230 240 VDVFYGCVMC QSFAPTHVCV ITPDRPALCG GINYLDARAA AKIDPNGPIF EIPKGECLDE 250 260 270 280 290 300 KLGIYSGVNE VVRERSQGTV EEVTLHSALE KPCTSCGCFE AIVFYIPEVD GFGIAHRGYK 310 320 330 340 350 360 GETPMGIPFS TLAGQCSGGK QVPGFVGISI SYMKSPKFLQ GDGGWERVVW LPKELKERVK 370 380 390 400 410 420 DAIPEELYDK IATEEDVKTT DELIKFLKEK GHPCAERIGA EVEEEAIEEE EVEEEMEEVE 430 440 450 460 GIEVPTMTLP GTFAGLPPGI KIVLYNAVIK AEKIIITKEE PEKKKKKKK

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98138.1.
PIR	E64319.
RefSeq	NP_247124.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q57620.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451000.
GenomeReviews	Gene locus MJ0156 in contig L77117_GR.
KEGG	mja:MJ_0156.
NMPDR	fig|243232.1.peg.161.
TIGR	MJ0156.
Phylogenomic databases
HOGENOM	HBG456963.
OMA	KFLQADG.
ProtClustDB	PRK04456.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0156-MONOMER.
Family and domain databases
HAMAP	MF_01138. CdhC. [Tree]
InterPro	IPR004461. CO_DH/Ac-CoA_synth_bsu. IPR023432. CO_DH/Ac-CoA_synth_bsu_arc. IPR011254. Prismane-like. [Graphical view]
KO	K00193.
Pfam	PF03598. CdhC. 1 hit. [Graphical view]
SUPFAM	SSF56821. Prismane_like. 1 hit.
TIGRFAMs	TIGR00316. CdhC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDB2_METJA

Accession

Primary (citable) accession number: Q57620

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program