Acetyl-CoA decarbonylase/synthase complex subunit beta 1 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Acetyl-CoA decarbonylase/synthase complex subunit beta 1
Short name=ACDS complex subunit beta 1
EC=2.3.1.-

Alternative name(s):
ACDS complex acyltransferase 1

Gene names

Name:	cdhC1
Ordered Locus Names:	MJ0152

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	748 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO₂ By similarity. HAMAP MF_01138
Catalytic activity	Acetyl-CoA + [acetyl-CoA decarbonylase/synthase complex beta subunit] = CoA + acetyl-[acetyl-CoA decarbonylase/synthase complex beta subunit]. HAMAP MF_01138
Cofactor	Binds 1 nickel-iron-sulfur cluster By similarity. HAMAP MF_01138
Subunit structure	Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha₂epsilon₂)(4)-beta(8)-(gamma₁delta₁)₈ Potential.
Sequence similarities	Belongs to the CdhC family.

Ontologies

Keywords
Ligand	Iron Iron-sulfur Metal-binding Nickel
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbon-monoxide dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: InterPro iron-sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 748

748

Acetyl-CoA decarbonylase/synthase complex subunit beta 1 HAMAP MF_01138

PRO_0000155101

Regions

Compositional bias

692 – 714

23

Glu-rich HAMAP MF_01138

Sites

Metal binding

480

1

Nickel-iron-sulfur Potential

Metal binding

483

1

Nickel-iron-sulfur Potential

Metal binding

569

1

Nickel-iron-sulfur Potential

Metal binding

571

1

Nickel-iron-sulfur Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q57616 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3BD5E42A4ABA3E8E
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FASTA

748

82,957

        10         20         30         40         50         60 
MKIRLYGETM VVGNIIEGGK TVLNLTKEIL EKEDENLKVS YPGTNYNLPI IYGLLGKKIE 

        70         80         90        100        110        120 
TVKDLKELIN SLEIKDEETL ENALDAGVVT LICAEAIEAL KYAKSEKPYK EPYVGFIPDE 

       130        140        150        160        170        180 
ILRGLGVPLV EGKIPAILVV IGKVGDKEKL KKLIDDIKKR NILALLVGDI VKEMDEADIE 

       190        200        210        220        230        240 
YGLDKLLVPV GNEITSAIHA ANLAIRAPLI FGGIEPGKTE EIIDYLKNRV PAVVVALGEL 

       250        260        270        280        290        300 
DNITLAAGAG CIKAGVPVIT NNEVPVIKGA LESSDIDNIV ENALKMKGVK VKVVEFDIPV 

       310        320        330        340        350        360 
SVGPMNEGER VRGPDMYVEL AGPKSYGFEL VKVVNKAEDK VEIIGKDIDE MEEGSRNPFA 

       370        380        390        400        410        420 
IIVEVSGSNL EEDLEGVLER RIHEFLNYIE GVMHLNQRDQ VWIRINKNSF NKGLRLKHIG 

       430        440        450        460        470        480 
EVVKQLFKEH FPIVEKCNVI IITDPDKVKE ELEKAKEIYK KRDEKTKSIR EEDVDVFYGC 

       490        500        510        520        530        540 
VMCQSFAPTH VCIITPDRPS LCGSINYLDA RAAAKIDPNG PIFEIPKGEC LDEKLGIYTG 

       550        560        570        580        590        600 
VNEVVRERSQ GSVEEMALHS ALTNPCTSCG CFEAIVFYIP EVDGFGVAHR NFRGETPFGL 

       610        620        630        640        650        660 
PFSTLAGQCS GGKQVPGFVG ISISYMKSPK FLQGDGGWER VVWLPKELKE RVKDAIPEEL 

       670        680        690        700        710        720 
YDKIATEEDV KTTDELIKFL KEKGHPIVKK TEEEVVEEVE EEKEEVKATE EEKEGIEVGE 

       730        740 
LITKLAKEGG IQIIMKNVKI VINLNVKR

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References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G.

Venter J.C.
Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98134.1.
PIR	A64319.
RefSeq	NP_247120.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q57616.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1450996.
GenomeReviews	Gene locus MJ0152 in contig L77117_GR.
KEGG	mja:MJ_0152.
NMPDR	fig\|243232.1.peg.157.
TIGR	MJ0152.
Phylogenomic databases
HOGENOM	HBG304432.
OMA	HIGQRDI.
ProtClustDB	PRK09529.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0152-MONOMER.
Family and domain databases
HAMAP	MF_01138. CdhC. Divergent sequence. [Tree]
InterPro	IPR004461. CO_DH/Ac-CoA_synth_bsu. IPR023432. CO_DH/Ac-CoA_synth_bsu_arc. IPR011254. Prismane-like. IPR016099. Prismane-like_a/b-sand. [Graphical view]
Gene3D	G3DSA:3.40.50.2030. Prismane-like_a/b-sand. 1 hit.
KO	K00193.
Pfam	PF03598. CdhC. 1 hit. [Graphical view]
SUPFAM	SSF56821. Prismane_like. 1 hit.
TIGRFAMs	TIGR00316. CdhC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDB1_METJA

Accession

Primary (citable) accession number: Q57616

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents