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Q57572

- KPYK_METJA

UniProt

Q57572 - KPYK_METJA

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Protein

Pyruvate kinase

Gene

MJ0108

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.By similarity
Potassium.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331SubstrateBy similarity
Metal bindingi35 – 351PotassiumBy similarity
Metal bindingi37 – 371PotassiumBy similarity
Metal bindingi61 – 611PotassiumBy similarity
Sitei201 – 2011Transition state stabilizerBy similarity
Metal bindingi203 – 2031MagnesiumBy similarity
Binding sitei226 – 2261Substrate; via amide nitrogenBy similarity
Metal bindingi227 – 2271MagnesiumBy similarity
Binding sitei227 – 2271Substrate; via amide nitrogenBy similarity
Binding sitei259 – 2591SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Ordered Locus Names:MJ0108
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Pyruvate kinasePRO_0000112128Add
BLAST

Proteomic databases

PRIDEiQ57572.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi243232.MJ0108.

Structurei

3D structure databases

ProteinModelPortaliQ57572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0469.
InParanoidiQ57572.
KOiK00873.
OMAiTPTYSGR.
PhylomeDBiQ57572.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57572-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGMMRKTKI LVTLGPSLEN KLDKAINLID GVRFNMSHAT TDYCEKFLNI
60 70 80 90 100
LEKNNIAKVM DLKGIKIRIK EVKLKNKILK MGEKVVIGED IKLNYNIDTI
110 120 130 140 150
EEGHFILIND GKIKLRVVEK TDKIIAVVEV GGEIKEGMGV NLPDTRIELP
160 170 180 190 200
IIDETDLKNI KFAVEKDFEY IALSFVRNKE DVKELKDIIS EYKGDCEVIS
210 220 230 240 250
KIETKEGLKN IKEIARESDG VMVARGDLGV EVPIENIPIE QKNILRIANR
260 270 280 290 300
YGILSITATQ ILDSMINNPF PTRAEVTDIA NAIYDGTDCL MLSNETTIGK
310 320 330 340 350
YPIEAIKVLN KVAKVADEHY EEFGDRVCLE VESIDEGLVY AVYELYKKLN
360 370 380 390 400
TKLVITPTYS GRTAKLISKL RINSKIIAPT PNIRTLKRLR LVWGVESCLM
410 420 430 440
EEFDDMEKII NTCREMAKKE IGKGIYLITL GHPIGQKKTN TIKVESI
Length:447
Mass (Da):50,490
Last modified:November 1, 1997 - v1
Checksum:iEA6C4DC031B8C1A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98090.1.
PIRiD64313.
RefSeqiNP_247072.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98090; AAB98090; MJ_0108.
GeneIDi1450949.
KEGGimja:MJ_0108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98090.1 .
PIRi D64313.
RefSeqi NP_247072.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q57572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0108.

Proteomic databases

PRIDEi Q57572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98090 ; AAB98090 ; MJ_0108 .
GeneIDi 1450949.
KEGGi mja:MJ_0108.

Phylogenomic databases

eggNOGi COG0469.
InParanoidi Q57572.
KOi K00873.
OMAi TPTYSGR.
PhylomeDBi Q57572.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiKPYK_METJA
AccessioniPrimary (citable) accession number: Q57572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3